Folate metabolism (Homo sapiens)
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Protein | |||
S-Adenosylhomocysteine | Metabolite | HMDB00939 (HMDB) | |
S-Adenosylmethionine | Metabolite | HMDB01185 (HMDB) | |
(11R)-hydroxymethylene-THF | Metabolite | (11R)-hydroxymethylenetetrahydrofolate | |
(11S)-hydroxymethylene-THF | Metabolite | (11S)-hydroxymethylenetetrahydrofolate | |
10-Formyl-THF | Metabolite | HMDB00972 (HMDB) | 10-formyltetrahydrofolate |
5,10-Methenyl-THF | Metabolite | HMDB01354 (HMDB) | 5,10-Methenyltetrahydrofolic acid |
5,10-Methylene-THF | Metabolite | HMDB01533 (HMDB) | 5,10-Methylenetetrahydrofolate |
5-Formyl-THF | Metabolite | HMDB01562 (HMDB) | 5-Formyltetrahydrofolate |
5-methyl-THF | Metabolite | HMDB01396 (HMDB) |
|
8-Isoprostaglandin F2a | Metabolite | HMDB05083 (HMDB) | |
8-OHdG | Metabolite | HMDB03333 (HMDB) | 8-Hydroxy-deoxyguanosine |
ABCA1 | Protein | 19 (Entrez Gene) | ATP-binding cassette, sub-family A (ABC1), member 1 |
ACT | Protein | 12 (Entrez Gene) |
|
ADP | Metabolite | HMDB01341 (HMDB) | Adenosine diphosphate |
AHCY | Protein | 191 (Entrez Gene) |
|
ALB | Protein | 213 (Entrez Gene) | albumin |
APOA1-NO2Tyr | Protein | 335 (Entrez Gene) | Nitrotyrosinated apolipoprotein A-I |
APOA1 | Protein | 335 (Entrez Gene) | apolipoprotein A-I |
APOB | Protein | 338 (Entrez Gene) | apolipoprotein B |
ATP | Metabolite | HMDB00538 (HMDB) | Adenosine triphosphate |
CBS | Protein | 875 (Entrez Gene) |
|
CRP | Protein | 1401 (Entrez Gene) | C-reactive protein, pentraxin-related |
CSF1 | Protein | 1435 (Entrez Gene) | colony stimulating factor 1 (macrophage) |
CTH | Protein | 1491 (Entrez Gene) |
|
Catalase | Protein | 847 (Entrez Gene) | EC 1.11.1.6 |
Chlorine | Metabolite | HMDB00492 (HMDB) | |
Cholesterol | Metabolite | HMDB00067 (HMDB) | |
Cob(I)alamin | Metabolite | HMDB02174 (HMDB) | Reduced cobalamin |
Cob(II)alamin | Metabolite | HMDB02174 (HMDB) | oxidized cobalamin |
Cystathionine | Metabolite | HMDB00099 (HMDB) | |
Cysteine | Metabolite | HMDB00574 (HMDB) | |
D-dimer | Protein | (Wikipedia) | http://en.wikipedia.org/wiki/Fibrin_degradation_product |
DHFR | Protein | 1719 (Entrez Gene) |
|
Dihydrofolate | Metabolite | HMDB01056 (HMDB) | |
F2-Isoprostane | Metabolite | 53788444 (PubChem) | |
FAD | Metabolite | HMDB01248 (HMDB) | Flavin adenine dinucleotide |
FGAR | Metabolite | 18272 (ChEBI) | formylglycinamide ribonucleotide |
FLAD1 | Protein | 80308 (Entrez Gene) |
|
FMN | Metabolite | HMDB01520 (HMDB) | Flavin Mononucleotide |
FOLR1 | GeneProduct | 2348 (Entrez Gene) | folate receptor 1 (adult) |
FOLR2 | GeneProduct | 2350 (Entrez Gene) | folate receptor 2 (fetal) |
FOLR3 | GeneProduct | 2352 (Entrez Gene) | folate receptor 3 (gamma) |
FOLR4 | GeneProduct | 390243 (Entrez Gene) | folate receptor 4 (delta) homolog (mouse) |
Factor VII | Protein | 2155 (Entrez Gene) |
|
Fibrin | Protein | 439199 (PubChem) | |
Fibrinogen | Protein | GO:0005577 (Other) | |
Folate | Metabolite | 37445 (ChEBI) | Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). |
Folic acid | Metabolite | HMDB00121 (HMDB) | Synthetic folate |
Fructosamine | Metabolite | HMDB02030 (HMDB) | |
GAR | Metabolite | HMDB02022 (HMDB) | glycinamide ribonucleotide |
GART | Protein | 2618 (Entrez Gene) |
|
GPX 1 | Protein | 2876 (Entrez Gene) |
|
GPX 2 | Protein | 2877 (Entrez Gene) |
|
GPX 3 | Protein | 2878 (Entrez Gene) |
|
GPX 4 | Protein | 2879 (Entrez Gene) |
|
GPX 6 | Protein | 257202 (Entrez Gene) |
|
Glucose | Metabolite | HMDB00122 (HMDB) | |
Glycine | Metabolite | HMDB00123 (HMDB) | |
H2O2 | Metabolite | HMDB03125 (HMDB) | Hydrogen peroxide |
H2O | Metabolite | HMDB02111 (HMDB) | Glutathione disulfide |
HBA1 | Protein | 3039 (Entrez Gene) | hemoglobin, alpha 1 |
HBB | Protein | 3043 (Entrez Gene) | hemoglobin, beta |
HDL-C | Metabolite | 47775 (ChEBI) |
|
HDL/APOA1 | Metabolite | 39025 (ChEBI) |
|
HDL/SAA | Metabolite | 39025 (ChEBI) |
|
HDL | Metabolite | 39025 (ChEBI) | high-density lipoprotein |
HNO2 | Metabolite | 25567 (ChEBI) | Nitrous acid |
HOCl | Metabolite | HMDB01050 (HMDB) | Hypochlorite |
HbA1c | Protein |
| |
Heme | Metabolite | HMDB03178 (HMDB) | |
Homocysteine | Metabolite | HMDB00742 (HMDB) | |
IFNg | Protein | 3458 (Entrez Gene) | interferon, gamma |
IL10 | Protein | 3458 (Entrez Gene) | interferon, gamma |
IL1B | Protein | 3553 (Entrez Gene) | interleukin 1, beta |
IL2 | Protein | 3558 (Entrez Gene) | interleukin 2 |
IL4 | Protein | 3565 (Entrez Gene) | interleukin 4 |
IL6 | Protein | 3569 (Entrez Gene) | interleukin 6 (interferon, beta 2) |
INS | Protein | 3630 (Entrez Gene) | Insulin |
INSR | Protein | 3643 (Entrez Gene) | Insulin receptor |
Iron | Metabolite | HMDB00692 (HMDB) | |
L-Arginine | Metabolite | HMDB00517 (HMDB) | |
LDL | Metabolite | 39026 (ChEBI) | low-density lipoprotein |
LDLR | Protein | 3949 (Entrez Gene) | low density lipoprotein receptor |
MAT | Protein | 4143 (Entrez Gene) |
|
MCP1 | GeneProduct | 6347 (Entrez Gene) |
|
MPO | Protein | 4353 (Entrez Gene) |
|
MSR* | Protein | 4552 (Entrez Gene) |
|
MTHFD1* | Protein | 4522 (Entrez Gene) |
|
MTHFD2 | Protein | 10797 (Entrez Gene) |
|
MTHFR* | Protein | 4524 (Entrez Gene) |
|
MTHFS | Protein | 10588 (Entrez Gene) |
|
MTR* | Protein | 4548 (Entrez Gene) |
|
Magnesium | Metabolite | HMDB00547 (HMDB) | |
Manganese | Metabolite | HMDB01333 (HMDB) | |
Methionine | Metabolite | HMDB00696 (HMDB) | |
NADP+ | Metabolite | HMDB00217 (HMDB) | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADPH | Metabolite | HMDB00221 (HMDB) | Nicotinamide adenine dinucleotide phosphate-Reduced |
NFkB1 | GeneProduct | 4790 (Entrez Gene) | nuclear factor NF-kappa-B p50 subunit |
NFkB2 | GeneProduct | 4791 (Entrez Gene) | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 |
NO2 | Metabolite | 33101 (ChEBI) | Nitrogen dioxide |
NO | Metabolite | HMDB03378 (HMDB) | Nitric oxide |
NOS | Protein | EC 1.14.13.39 (EC Number) | Nitric oxide synthase |
Nitrotyrosine | Metabolite | HMDB01904 (HMDB) | |
O2 · – | Metabolite | HMDB02168 (HMDB) | Superoxide |
O2 | Metabolite | HMDB01377 (HMDB) | |
O3 | Metabolite | 25812 (ChEBI) | ozone |
ONOO–/ONOOH | Metabolite | HMDB02179 (HMDB) | Peroxynitrite |
PAI-1 | Protein | 5054 (Entrez Gene) | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
PGE1 | Metabolite | HMDB01442 (HMDB) | Prostaglandin E1 |
PGE2 | Metabolite | HMDB01220 (HMDB) | Prostaglandin E2 |
PGF2a | Metabolite | HMDB01139 (HMDB) | Prostaglandin F2a |
PLG | Protein | 5340 (Entrez Gene) |
|
Pyridoxal 5'-phosphate | Metabolite | HMDB01491 (HMDB) | |
RELA | GeneProduct | 5970 (Entrez Gene) | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 |
RFK | Protein | 55312 (Entrez Gene) |
|
RNS | Metabolite |
| |
Riboflavin | Metabolite | HMDB00244 (HMDB) | |
S-nitrosohomocysteine | Metabolite | 76468969 (PubChem) | |
SAA1 | Protein | 6288 (Entrez Gene) | serum amyloid A1 |
SAA2 | Protein | 6289 (Entrez Gene) | serum amyloid A2 |
SAA3 | Protein | 6290 (Entrez Gene) | serum amyloid A3 pseudogene |
SAA4 | Protein | 6291 (Entrez Gene) | serum amyloid A4, constitutive |
SHMT | Protein | 6470 (Entrez Gene) |
|
SHMT | Protein | 6472 (Entrez Gene) |
|
SLC19A1 | GeneProduct | 6573 (Entrez Gene) | solute carrier family 19 (folate transporter), member 1 |
SLC46A1 | GeneProduct | 113235 (Entrez Gene) | solute carrier family 46 (folate transporter), member 1 |
SOD1 | Protein | 6647 (Entrez Gene) |
|
SOD2 | Protein | 6648 (Entrez Gene) |
|
SOD3 | Protein | 6649 (Entrez Gene) |
|
SRB1 | Protein | 949 (Entrez Gene) | scavenger receptor class B, member 1 |
Serine | Metabolite | HMDB00187 (HMDB) | |
TAG | Metabolite | 17855 (ChEBI) |
|
THF | Metabolite | HMDB01846 (HMDB) | Tetrahydrofolic acid |
TNFa | Protein | 7124 (Entrez Gene) | tumor necrosis factor (TNF superfamily, member 2) |
Tetrahydrobiopterin | Metabolite | HMDB00027 (HMDB) | H4B |
Thrombin | Protein | 2147 (Entrez Gene) |
|
Thromboxane A2 | Metabolite | HMDB01452 (HMDB) | |
Thromboxane B2 | Metabolite | HMDB03252 (HMDB) | |
VLDL-TAG | Metabolite | 47776 (ChEBI) |
|
VLDL/APOB | Metabolite | 39027 (ChEBI) |
|
VLDL | Metabolite | 39027 (ChEBI) | very-low-density lipoprotein |
Zinc | Metabolite | HMDB01303 (HMDB) | |
oxLDL | Metabolite | 39026 (ChEBI) | oxidized low-density lipoprotein |
p53 | GeneProduct | 7157 (Entrez Gene) | tumor protein p53 |
sICAM-1 | Protein | 3383 (Entrez Gene) | soluble intercellular adhesion molecule 1 |
tPA | Protein | 5327 (Entrez Gene) |
|
Annotated Interactions
No annotated interactions