DNA replication (Caenorhabditis elegans)

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Mcm4Orc2Phosphorylated Orc1Cdt1Mcm2dUTPOrc complexRNA PrimerCTPDNA PolymeraseOrc complexp58Mcm 4,6,7 trimer forms and associatesDNA polymerase alpha: primase: origin complex5. Leading/lagging strand synthesisPhosphorylated Cdc6PCNA homotrimerdATPRFC Heteropentamer:RNA primer-DNA primer:Processive complexDegraded by proteasome in cytosolOrc5Mcm5Pre-replicative complexCdc6UbiquitinOrc3ADPRFC36Mcm6ATPOrc2Orc4Mcm7aDNA polymerase alpha: primase: origin complexMcm6Cdc6Ubiquitinated Cdc6dCTPMcm4PrimaseATPOrc54. Switching of origins to post-replicative stateATPCdc6Mcm2RNA primer-DNA primer1. Assembly of the pre-replicative complexOrc complexOrigin3. DNA replication initiationUbiquitinOrc ComplexGTPCdt1dGTPATPUbiquitinated Orc1Orc2Orc3p70Orc2Orc4UTPOrc1GemininCdt1Orc3Phosphorylation of Mcm 2-7 complexwith the replication forkPre-replicative complexMcm10Orc3Degraded by proteasome in cytosolp180Mcm3RFC1402. Activation of the pre-replicative complexRFC Heteropentamer:RNA primer-DNA primerOrc complexRFC37Mcm5Cdt1Cdt1Cdc6Mcm3RFC38ADPp49RNA primer-DNA primer:origin duplex:PCNAOrc5Mcm7RFC40RNA primer-DNA primerRFC4rfc-3F33H2.5POLD3ORC4Lorc-2mcm-4CDC7mcm-2Y39A1A.12rfc-2F34D10.2ubq-1Y47D3A.28Y47D3A.29RPA1pri-1ubq-2ORC6LPOLD4mcm-7ORC5LGMNNCDK2ORC3Lcdc-6CDT1mcm-6rfc-1div-1ARPACDC46ASKPOLD2RPA2PCNARPA4F08B4.5RPA3mcm-3F10C2.4pri-2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
ATPMetabolite
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetabolite
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
GTPMetabolite
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
UTPMetabolite
UbiquitinMetabolite
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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