DNA replication (Caenorhabditis elegans)

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dUTPp58Mcm4ADPOrc complexRNA primer-DNA primerRFC Heteropentamer:RNA primer-DNA primerMcm3Phosphorylated Orc1RFC Heteropentamer:RNA primer-DNA primer:dATPOrc complexOrc1Mcm3ATPCdt1Mcm7Orc3ADPPre-replicative complexOriginPhosphorylation of Mcm 2-7 complexGTPDNA polymerase alpha: primase: origin complexPCNA homotrimer5. Leading/lagging strand synthesisOrc5Mcm6aUbiquitinated Orc1dGTPATP4. Switching of origins to post-replicative stateATPGemininMcm2CTPMcm6Orc4p70Mcm5p180Phosphorylated Cdc6ATPUbiquitinOrc2Mcm 4,6,7 trimer forms and associatesRNA PrimerOrc21. Assembly of the pre-replicative complexRFC40Orc3RNA primer-DNA primerPrimaseOrc complexDegraded by proteasome in cytosoldCTPRFC36Orc complexOrc3Mcm10Orc3Cdt1Processive complexMcm7Pre-replicative complexMcm23. DNA replication initiationUbiquitinCdc6Degraded by proteasome in cytosolOrc2Orc5Orc ComplexCdc6RFC140Cdt1Mcm5Cdt1Ubiquitinated Cdc6Cdt1RNA primer-DNA primer:origin duplex:PCNAOrc2DNA PolymeraseRFC38UTPRFC37p49Cdc62. Activation of the pre-replicative complexOrc4DNA polymerase alpha: primase: origin complexMcm4with the replication forkCdc6Orc5mcm-2POLD2RPA3CDT1ORC5LPOLD3PCNAF10C2.4F08B4.5rfc-1mcm-7RPA2RPA4ORC3LGMNNF33H2.5RFC4rfc-3F34D10.2ORC4LASKmcm-4ubq-1CDC46CDK2cdc-6Y47D3A.28ubq-2ORC6Lmcm-3ARPAmcm-6Y47D3A.29pri-2RPA1orc-2rfc-2pri-1Y39A1A.12div-1POLD4CDC7


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
ATPMetabolite
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetabolite
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
GTPMetabolite
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
UTPMetabolite
UbiquitinMetabolite
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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