DNA replication (Caenorhabditis elegans)

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ATPRFC36Orc ComplexOrc2Mcm5p70RNA primer-DNA primer:origin duplex:PCNAOrc3Mcm7Ubiquitinated Cdc6DNA PolymeraseADPOrc4Mcm7CTPCdt1Cdt1RFC Heteropentamer:RNA primer-DNA primer:ATPMcm3Orc5RNA PrimerdCTPPhosphorylated Orc1PrimaseOrc complexOrc55. Leading/lagging strand synthesis3. DNA replication initiationDegraded by proteasome in cytosolUbiquitindUTPProcessive complexMcm10Mcm6ATPCdc6Cdc6RFC37RFC38Degraded by proteasome in cytosolOriginADPOrc3Orc3UTPOrc2Ubiquitinated Orc1PCNA homotrimerMcm4UbiquitinOrc1p58Pre-replicative complexMcm5RNA primer-DNA primerGTPdATPRFC40Orc complexOrc2DNA polymerase alpha: primase: origin complexOrc2Phosphorylation of Mcm 2-7 complexOrc complexOrc complexPre-replicative complexMcm6Mcm2ATPCdt1p49Orc4Cdc6Mcm2Mcm3with the replication forkCdc6Mcm4RNA primer-DNA primerDNA polymerase alpha: primase: origin complexaCdt12. Activation of the pre-replicative complexMcm 4,6,7 trimer forms and associatesdGTPRFC140p180Cdt11. Assembly of the pre-replicative complexOrc5Phosphorylated Cdc64. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primerGemininOrc3Y47D3A.29CDK2F10C2.4pri-1CDC46ORC6LRPA2cdc-6RPA1orc-2CDC7div-1pri-2ORC4Lmcm-6ORC5Lrfc-1PCNAPOLD4GMNNF34D10.2mcm-7mcm-2RFC4ARPAmcm-4ubq-2Y47D3A.28rfc-2mcm-3F08B4.5RPA3RPA4ORC3LPOLD3Y39A1A.12ASKF33H2.5CDT1rfc-3ubq-1POLD2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
ATPMetaboliteCHEBI:15422 (ChEBI)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetaboliteCHEBI:17677 (ChEBI)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
GTPMetaboliteCHEBI:15996 (ChEBI)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
UTPMetaboliteCHEBI:15713 (ChEBI)
UbiquitinMetabolite
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetaboliteCHEBI:16284 (ChEBI)
dCTPMetaboliteCHEBI:16311 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)
dUTPMetaboliteCHEBI:17625 (ChEBI)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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