Aryl hydrocarbon receptor pathway (Homo sapiens)

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251816, 30367, 43, 49243446151, 41194, 944374428STAT122CyNuHSP902ActivationTCDD16CyNuNEDD8SUMO7CyNuCyNuNucleusproliferation and tumorigenesis RETNqo1ZAC1Calcium ChannelVEGFCYP1A1p27Kip1EGFREBNA-3KLF6pRbAIPPAHNrf2Hsp90ERCCL1p300ARNTXREDRE regionTCDD358, 16, 301521, 2426, 5436342320AIPL43, 48, 5532115, 17, 2547, 51P29AHRP23AHR2, 14AHR16HSP906, 53HSP9045C-myc38TATAEGFR PathwayTNF-α7CDC37c-srcRAF1P41MAP2K1PPERK1/2COX-2SRC-119Rel Ap50Rel Ap50p30050SRC-1AngiogenesisERAP140RIP140CYP1A1CD36Lpl39Nrf2Fgf21GstsGclcOxidative StressRIP140NF-1NCOA742SMRT57CYP1A227CYP1B13, 33Estrogen Metabolism and modulation of Estrogen receptor signallingEnzyme ComplexProteinReceptorLigandmRNASmall moleculeInduced activationInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavageProteinMoleculep21cip131, 56CDK2RbE2F1Cell cycle inhibitionDetoxification of Xenobiotics and metabolism of xenobioticsCell SurvivalAHRRp300FAS/ FAS-L (Apoptosis)52NRASHRASKRASTCDD5, 17, 25PAH26, 54Cell Survival13


Description

The Aryl Hydrocarbon receptor (AhR) is ligand activated transcription factor that regulates wide spectrum of gene expression. The main mediator of AhR is 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or polycyclic aromatic hydrocarbons which are widespread environmental pollutant causing a variety of severe health effects, e.g. immunosuppression, carcinogenesis and hepatotoxicity.

AhR is a member of basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. In the absence of ligand, the AhR can be found in the cytosol, bound to a dimer of the heat shock protein of 90 kDa (Hsp90) and the immunophilin-like protein, AIP (also known as XAP2 and ARA9). Upon ligand binding, the AHR translocates to the nucleus and binds with ARNT. The AHR/ARNT heterodimer binds to xenobiotic response elements and regulates a diverse set of genes

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Bibliography

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History

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CompareRevisionActionTimeUserComment
126477view20:59, 5 May 2023EgonwAdded an identifier for the calcium channel
121728view01:30, 27 February 2022EweitzUse gene symbols
121727view20:09, 26 February 2022EweitzReplace text node with gene node in complex, and replace its references
121726view19:56, 26 February 2022EweitzCopy BiopaxRef to new node
121725view19:52, 26 February 2022EweitzDraft change
121724view19:35, 26 February 2022EweitzRefine case and copyediting
120796view20:59, 8 January 2022AlexanderPicoReverted to version '04:12, 17 December 2021' by AlexanderPico
120574view11:14, 17 December 2021EweitzModified description
120573view11:12, 17 December 2021EweitzModified title
117654view11:46, 22 May 2021EweitzModified title
115347view10:30, 15 February 2021EgonwMade six more pathways clickable
107439view07:01, 8 October 2019DeSlModified title
107135view14:21, 17 September 2019MaintBotChEBI identifier normalization
106305view17:45, 20 August 2019KhanspersModified description
105536view06:04, 9 August 2019KhanspersModified description
91687view13:42, 29 March 2017DeSlAnnotation update for several datanodes
91671view13:20, 29 March 2017DeSlAnnotation update for angiogenesis
89793view10:53, 6 October 2016Mkutmonfixed special character in datanode label
88982view09:41, 18 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
88981view09:40, 18 August 2016MirellaKalafatiReverted to version '08:09, 17 August 2016' by MirellaKalafati
88901view08:13, 17 August 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
88900view08:09, 17 August 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
88899view08:09, 17 August 2016MirellaKalafatiOntology Term : 'DOID:5395' removed !
85335view16:12, 7 May 2016EgonwReplaced a mim-conversion with Arrow.
79995view21:04, 29 April 2015ZariAnnotated EBNA-3,COX-2,ERK1/2 , CYP1A1 and Gsts
78547view10:30, 7 January 2015MaintBotadded missing graphIds
76318view06:58, 2 July 2014Mkutmonfixed datasource for pRb datanode
73592view16:10, 3 February 2014Prakamya1986Modified description
73591view16:06, 3 February 2014Prakamya1986Modified description
73590view15:53, 3 February 2014Prakamya1986Specify description
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProduct196 (Entrez Gene)
AHRRGeneProduct57491 (Entrez Gene)
AIPGeneProductENSG00000110711 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
AngiogenesisPathway
C-mycProtein4609 (Entrez Gene)
CCL1GeneProduct6346 (Entrez Gene) PMID: 16679317 PAHs induce expression of the chemokine CCL1 in an AhR- and calcium-dependent manner.
CD36GeneProduct948 (Entrez Gene)
CDC37GeneProduct11140 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
COX-2GeneProduct5743 (Entrez Gene)
CYP1A1Protein
CYP1A1GeneProduct1543 (Entrez Gene)
CYP1A2GeneProduct1544 (Entrez Gene)
CYP1B1GeneProduct1545 (Entrez Gene)
Calcium Channel
Cell SurvivalPathway
Cell Survival Pathway
Cell cycle inhibitionPathway
DRE regionComplex
Detoxification of Xenobiotics and metabolism of xenobiotics Pathway
E2F1GeneProduct1869 (Entrez Gene)
EBNA-3Protein17494212 (Entrez Gene)
EGFR Pathway
EGFRGeneProduct1956 (Entrez Gene)
ERProtein2099 (Entrez Gene) Estrogen Receptor
ERAP140Protein135112 (Entrez Gene) Official Symbol= NCOA7
ERK1/2 Protein
Estrogen Metabolism and modulation of Estrogen receptor signallingPathway
FAS/ FAS-L (Apoptosis)Pathway
Fgf21Protein26291 (Entrez Gene)
GclcProtein2729 (Entrez Gene)
GstsProtein
HRASGeneProductENSG00000174775 (Ensembl)
HSP90GeneProduct3320 (Entrez Gene)
Hsp90Protein3320 (Entrez Gene)
KLF6GeneProduct1316 (Entrez Gene)
KRASGeneProductENSG00000133703 (Ensembl)
LplProtein4023 (Entrez Gene) lipoprotein lipase
MAP2K1GeneProductENSG00000169032 (Ensembl)
NCOA7Protein135112 (Entrez Gene)
NF-1Protein4763 (Entrez Gene)
NRASGeneProductENSG00000213281 (Ensembl)
Nqo1Protein1728 (Entrez Gene)
Nrf2GeneProduct4780 (Entrez Gene)
Oxidative Stress Pathway
P23GeneProductENSG00000110711 (Ensembl)
PAHMetabolite33848 (ChEBI)
ProteinGeneProduct
ProteinProtein5894 (Entrez Gene)
RAF1GeneProductENSG00000132155 (Ensembl)
RETProtein5979 (Entrez Gene)
RIP140Protein8204 (Entrez Gene)
RbGeneProduct5925 (Entrez Gene)
Rel AGeneProduct5970 (Entrez Gene)
SMRTProtein9612 (Entrez Gene)
SRC-1GeneProduct84722 (Entrez Gene)
TATAComplex
TCDDMetabolite28119 (ChEBI)
TNF-αGeneProduct7124 (Entrez Gene)
VEGFGeneProduct7422 (Entrez Gene)
XRExenobiotic responsive element
ZAC1Protein5325 (Entrez Gene)
c-srcProtein6714 (Entrez Gene)
p21cip1GeneProduct1026 (Entrez Gene)
p27Kip1GeneProduct1027 (Entrez Gene)
p300Protein2033 (Entrez Gene)
p50GeneProduct4790 (Entrez Gene)
pRbProteinP06400.2 (Uniprot-SwissProt)
proliferation and tumorigenesis Pathway

Annotated Interactions

No annotated interactions

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