NO/cGMP/PKG mediated neuroprotection (Homo sapiens)

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sGCNF-kBNR2 SubunitsNR1 SubunitMitochondrialPermeabilityTransitionPoreCAMK IINeuronNR1 Interacting ProteinsNucleusCalmodulinNatriuretric PeptidesNMDA ReceptorCNG Cation ChannelsMicrogliaSmall SolublesEndothelial CellMitochondrion B SubunitsA SubunitsNMDAR: Ligand ComplexCell DepolarizationNFKB3XIAPNPR1IL-1BIFN-GammaCNGA1TNF-anNOSCa2+L-GlutamateGUCY1A3NFKB1Cytochrome CcGMPCNGB3TSPOPKG2CNGA3PDE2Ca2+CREB1GRIN2DMg2+GRIN2CeNOSPDE3L-CitrullinecAMPCyclophilin DCNGB1O2LPSCASP9NFKBIACNGA4BNPCNGA2K+CALM1GUCY1B3GRIN2AGUCY1B2NADPCAMK2GGTPACTN2GUCY1A2NADPHTBHL-ArginineAKAP9NOiNOSNEFLGRIN1CAMK2AApoptosisCa2+GRIN2BDLG4AMPCAMK2BCaspase CascadeCAMK2DANPBCL2O2L-ArginineNADPHTBHNADPL-CitrullineNOACTN2DLG4NR2 Interacting ProteinsCalmodulinCa2+CALM1O2L-ArginineNADPHTBHNADPL-CitrullineNONOSmall SolublesK+Ca2+BADSmall SolublesK+Ca2+Small SolublesK+Ca2+Mitochondrial DepolarizationCytochrome C


Description

NO/cGMP/PKG Neuroprotection

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
125786view10:03, 10 March 2023DeSlConverted PW node to current color scheme, added link for caspase cascade
123318view07:41, 16 July 2022EgonwTyped a datanode
117805view14:30, 22 May 2021EweitzModified title
110707view14:19, 28 May 2020LaurentAdded missing DataNode types - and one missing ID
107157view14:24, 17 September 2019MaintBotChEBI identifier normalization
106656view21:17, 12 September 2019KhanspersModified description
105657view05:15, 10 August 2019KhanspersModified description
96448view09:26, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96378view06:46, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
92677view11:02, 28 June 2017SauerThorbenOntology Term : 'signaling pathway involving second messengers' added !
92676view11:01, 28 June 2017SauerThorbenOntology Term : 'signaling pathway' added !
92675view11:01, 28 June 2017SauerThorbenOntology Term : 'neuron' added !
92674view11:01, 28 June 2017SauerThorbenOntology Term : 'neural cell' added !
92673view11:01, 28 June 2017SauerThorbenOntology Term : 'dementia' added !
92672view09:59, 28 June 2017SauerThorbenModified title
92671view09:57, 28 June 2017SauerThorbenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTN2GeneProductENSG00000077522 (Ensembl)
AKAP9GeneProductENSG00000127914 (Ensembl)
AMPMetaboliteCHEBI:2356 (ChEBI)
ANPGeneProductENSG00000175206 (Ensembl)
Apoptosis
BADGeneProductENSG00000002330 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BNP GeneProductENSG00000120937 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CAMK2BGeneProductENSG00000058404 (Ensembl)
CAMK2DGeneProductENSG00000145349 (Ensembl)
CAMK2GGeneProductENSG00000148660 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CNGA1GeneProductENSG00000198515 (Ensembl)
CNGA2GeneProductENSG00000183862 (Ensembl)
CNGA3GeneProductENSG00000144191 (Ensembl)
CNGA4GeneProductENSG00000132259 (Ensembl)
CNGB1GeneProductENSG00000070729 (Ensembl)
CNGB3GeneProductENSG00000170289 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:3308 (ChEBI)
Caspase Cascade
Cyclophilin DGeneProductENSG00000171497 (Ensembl)
Cytochrome CGeneProductENSG00000172115 (Ensembl)
DLG4GeneProductENSG00000132535 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2D GeneProductENSG00000105464 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
IFN-GammaProteinENSG00000111537 (Ensembl)
IL-1BProteinENSG00000125538 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
L-ArginineMetabolite16467 (ChEBI)
L-CitrullineMetabolite16349 (ChEBI)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
LPS89981 (ChEBI)
Mg2+MetaboliteCHEBI:6635 (ChEBI)
NADP Metabolite18009 (ChEBI)
NADPHMetabolite16474 (ChEBI)
NEFLGeneProductENSG00000277586 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB3GeneProductENSG00000173039 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NOMetabolite16480 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
O2Metabolite29372 (ChEBI)
PDE2GeneProductENSG00000186642 (Ensembl)
PDE3GeneProductENSG00000172572 (Ensembl)
PKG2GeneProductENSG00000138669 (Ensembl)
TBHMetabolite64090 (ChEBI)
TNF-a ProteinENSG00000232810 (Ensembl)
TSPOGeneProductENSG00000100300 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)
cAMPMetaboliteCHEBI:1325 (ChEBI)
cGMPMetaboliteCHEBI:1327 (ChEBI)
eNOSGeneProductENSG00000164867 (Ensembl)
iNOSGeneProductENSG00000007171 (Ensembl)
nNOSGeneProductENSG00000089250 (Ensembl)

Annotated Interactions

No annotated interactions

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