Folate metabolism (Homo sapiens)

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225, 229102, 11614, 63, 100, 131, 203...17612, 125, 176, 197, 203214195, 237205300198, 21328732, 22616639, 141, 303is composed ofSelenoproteinsCofactor conversionConversionBiomarker forTranscription factorBindingMicronutrientsSelenium statusOverarching processCofactorsProtein*GlycogenesisCatalysisLipid peroxidationNegative EffectProtein with polymorphismNecessary stimulationFrom intracellular part to the plasmaInhibitionStimulationProcess or metabolism involved in Se PathwayMetabolitesCleavageLipoprotein melabolismEnzymesLEGENDOther proteinsProtein tyrosine nitrationReactionProstaglandins metabolismIntracellularMethylation reactionsDNA oxidationApoptosisNovo purine biosynthetic pathwayPlasmaFOLR2PGF2aPGE1Thromboxane A2SLC46A1F2-IsoprostaneFOLR3NFkB18-Isoprostaglandin F2a8-Isoprostaglandin F2aFOLR1FOLR4F2-IsoprostaneSLC19A1Thromboxane B2RELAp53PGE2NFkB2PGF2aMCP1PGE2MCP1PGE1Thromboxane B22216521, 2322916521, 162, 301652622212621626529129121, 21629112, 39, 160, 166, 245...16218030, 18021, 23221, 216AHCYSHMTMTHFD2MTR*MATMSR*DHFRMTHFD1*207, 325217, 252, 2968426, 120, 129, 20732, 16432, 12832166CBS120, 256NADP+NADP+NADP+NADP+NADP+NADP+NADP+NOSMPOCatalaseMPO37, 96, 125, 15037, 96, 125, 150176, 20930CysteineCysteinePLGPAI-1tPAThrombinPLGPAI-1ThrombinFactor VIItPAFactor VII3333108, 18723, 187108, 18723, 18733333333GPX 4H2O25,10-Methenyl-THFDihydrofolate5-Formyl-THFFGAR(11S)-hydroxymethylene-THFGAR5,10-Methylene-THF10-Formyl-THF(11R)-hydroxymethylene-THF32, 22632, 2263232323232, 296296325-methyl-THF5-methyl-THFFolateFolate296102, 141, 147, 166, 221...26, 296SOD3SOD3RFK121H2OGPX 3GPX 3CTH120Heme176, 209, 256THF296NADPHNADPHNADPHNADPHNADPHNADPHNADPHGPX 6ManganeseManganeseFolic acidFolic acid5, 129, 2965, 129, 296GPX 2GPX 1RNS176, 205SHMTGARTMTHFSMTHFR*129, 296323232, 226HomocysteineHomocysteine10826, 63, 108, 203, 221...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate30, 85, 30685, 306GlycineSerineGlycineL-Arginine32, 12832, 12832832, 128SAA1SRB1ACTHDL/APOA1APOA1-NO2TyrVLDLAPOBAPOA1VLDL/APOBLDLRCholesterolHDLACTTAGVLDLHDLABCA1HDL/SAASAA4FMNoxLDLHDL-CAPOBCholesterolLDLTAGoxLDLVLDL-TAGSAA3APOA1LDLSAA2VLDL-TAGHDL-C25719872, 17819819837, 70, 147, 213, 30914372, 178143, 23937, 70, 213, 3097237, 70, 147, 213, 309198198, 2747272198, 27472143, 239155, 19872155, 198, 274198, 27419872198147, 198198, 2741981559572147, 19837, 70, 213, 309O22378-OHdGCob(II)alaminCob(I)alaminFADFADCob(I)alamin8-OHdG207207, 325287207, 281, 325207, 281, 325287257ADPADPChlorineMagnesiumChlorineMagnesiumCystathionineS-nitrosohomocysteine310SOD2Serine32, 128ATPZincZincHNO2NONO2NOO3HOCl39, 96, 150, 31096, 150INSsICAM-1HBA1TNFaTNFaCSF1IL1BIL10FibrinFibrinogenIL10IL4IL2FibrinogenALBFibrinIL1BIFNgHbA1cHBBHbA1cIL6D-dimerCRPALBD-dimerIFNgCSF1INSINSRIL2IL6IL4104, 211131, 2031410063, 104, 270203, 289, 293, 322160293, 32233, 233100160, 227178, 228, 30027836, 22833, 2331601672784, 30, 70, 104, 195...14, 104, 203, 228291102, 289160, 227178, 228, 300102, 28916716723, 3323, 33167291131211Riboflavin219O2 S-AdenosylhomocysteineMethionine S-Adenosylmethionine S-Adenosylmethionine S-AdenosylhomocysteineMethionine26, 265, 296188, 29626549, 207, 296188, 29649, 166, 207, 296ADPONOO/ONOOHNitrotyrosineTetrahydrobiopterinNitrotyrosine328205205ATPATPFructosamineFructosamineGlucoseGlucose167, 300167, 300278278IronIron290290FLAD1121, 122


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

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History

View all...
CompareRevisionActionTimeUserComment
134132view12:12, 30 June 2024EgonwMarked the "From intracellular part to the plasma" interactions as mim-translocation
121696view03:31, 26 February 2022EweitzFix gene symbol
120904view14:08, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
120275view13:13, 23 November 2021EgonwRemoved duplicate reference data
118404view14:12, 27 May 2021Marvin M2empty refs removed, 1 pubmed Id added
117725view12:34, 22 May 2021EweitzModified title
107123view14:20, 17 September 2019MaintBotChEBI identifier normalization
106422view22:01, 28 August 2019KhanspersModified description
106179view12:07, 16 August 2019MaintBotHMDB identifier normalization
105599view04:49, 10 August 2019KhanspersModified description
105139view15:21, 10 July 2019DeSlUpdated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.
104839view14:22, 20 June 2019Fehrhartfixed an interaction NADPH - anchor
104837view14:16, 20 June 2019Fehrhart
101939view06:14, 19 November 2018EgonwReplaced Wikipedia with Wikidata identifiers.
98245view14:17, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
97550view14:45, 24 May 2018Youssefwalid
97549view14:44, 24 May 2018YoussefwalidNOS ID mapping to Uniprot
96337view15:34, 8 March 2018Mkutmonremove old WP category
96279view08:20, 5 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
95971view09:23, 11 February 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
95130view16:06, 16 November 2017Fehrhartconnecting unconnected connections
95129view16:03, 16 November 2017Fehrhartconnecting unconnected lines
93690view15:08, 9 August 2017DeSlModified description
85063view11:25, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82704view08:49, 23 October 2015EgonwoxLDL has a separate identifier.
79883view12:32, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 12831960)
79877view11:39, 23 April 2015Mkutmonuse labels and graphical lines in the legend
74202view07:11, 5 April 2014EgonwReplaced "Other" data sources with nothing and with Wikipedia.
74096view13:37, 29 March 2014EgonwFibrin from PubChem is a metabolite.
72364view09:11, 13 November 2013EgonwWhere WP identifiers were given as comment and Wikipedia already listed as DataSource, I fixed the identifier.
71710view20:02, 17 October 2013MaintBotremoved data source from nodes without identifier
70465view11:12, 5 August 2013EgonwLinked to the WP page.
70111view19:07, 12 July 2013MaintBotupdated to 2013 schema
68034view10:41, 29 June 2013EgonwMore char encoding fixes in references.
68033view10:26, 29 June 2013EgonwFixed char encoding issues in references.
68032view10:04, 29 June 2013EgonwFixed EC number data source.
68030view09:57, 29 June 2013EgonwFixed an char encoding issue in a reference.
60226view20:06, 14 March 2013EgonwRemoved more escape codes in PubChem-substance identifier, and replaced one with a PubChem-compound ID.
60225view20:03, 14 March 2013EgonwRemoved escape code.
57622view20:18, 30 January 2013EgonwFibrin PubChem references are PubChem-compound.
56291view16:08, 5 January 2013EgonwFixed fibrin node data type from protein to metabolite.
54695view12:27, 7 December 2012Andra
54694view12:17, 7 December 2012AndraSpecify description
49543view10:10, 20 July 2012AndraWp tidy
49538view09:38, 20 July 2012AndraCorrected error in identifier
48247view06:19, 17 May 2012MaintBotUpdating PubChem xrefs
45271view18:50, 7 October 2011AlexanderPicoOntology Term : 'pathway of folate cycle/metabolism' added !
41127view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39753view06:58, 17 January 2011AlexanderPicomore specific title
36515view12:55, 29 March 2010Damarizohdg

External references

DataNodes

View all...
NameTypeDatabase referenceComment
S-AdenosylhomocysteineMetaboliteHMDB00939 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
(11R)-hydroxymethylene-THFMetabolite(11R)-hydroxymethylenetetrahydrofolate
(11S)-hydroxymethylene-THFMetabolite(11S)-hydroxymethylenetetrahydrofolate
10-Formyl-THFMetaboliteHMDB00972 (HMDB) 10-formyltetrahydrofolate
5,10-Methenyl-THFMetaboliteHMDB01354 (HMDB) 5,10-Methenyltetrahydrofolic acid
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
5-Formyl-THFMetaboliteHMDB01562 (HMDB) 5-Formyltetrahydrofolate
5-methyl-THFMetaboliteHMDB01396 (HMDB)
  • 5-methyltetrahydrofolate
  • Predominant food folate
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
8-OHdGMetaboliteHMDB03333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
ADPMetaboliteHMDB01341 (HMDB) Adenosine diphosphate
AHCYProtein191 (Entrez Gene)
  • EC 3.3.1.1
  • Adenosylhomocysteinase
ALBProtein213 (Entrez Gene) albumin
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
APOBProtein338 (Entrez Gene) apolipoprotein B
ATPMetaboliteHMDB00538 (HMDB) Adenosine triphosphate
CBSProtein875 (Entrez Gene)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
CRPProtein1401 (Entrez Gene) C-reactive protein, pentraxin-related
CSF1Protein1435 (Entrez Gene) colony stimulating factor 1 (macrophage)
CTHProtein1491 (Entrez Gene)
  • EC 4.4.1.1
  • cystathionase
CatalaseProtein847 (Entrez Gene) EC 1.11.1.6
ChlorineMetaboliteHMDB00492 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
Cob(I)alaminMetaboliteHMDB02174 (HMDB) Reduced cobalamin
Cob(II)alaminMetaboliteHMDB02174 (HMDB) oxidized cobalamin
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
D-dimerProteinFibrin degradation product (Wikipedia) http://en.wikipedia.org/wiki/Fibrin_degradation_product
DHFRProtein1719 (Entrez Gene)
  • EC 1.5.1.3
  • Dihydrofolate reductase
DihydrofolateMetaboliteHMDB01056 (HMDB)
F2-IsoprostaneMetabolite53788444 (PubChem-substance)
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
FGARMetabolite18272 (ChEBI) formylglycinamide ribonucleotide
FLAD1Protein80308 (Entrez Gene)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
FMNMetaboliteHMDB01520 (HMDB) Flavin Mononucleotide
FOLR1GeneProduct2348 (Entrez Gene) folate receptor 1 (adult)
FOLR2GeneProduct2350 (Entrez Gene) folate receptor 2 (fetal)
FOLR3GeneProduct2352 (Entrez Gene) folate receptor 3 (gamma)
FOLR4GeneProduct390243 (Entrez Gene) folate receptor 4 (delta) homolog (mouse)
Factor VIIProtein2155 (Entrez Gene)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
FibrinMetabolite439199 (PubChem-compound)
FibrinMetabolite439199 (PubChem-compound)
FibrinogenProteinFibrinogen (Wikipedia)
FolateMetabolite37445 (ChEBI) Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid).
Folic acidMetaboliteHMDB00121 (HMDB) Synthetic folate
FructosamineMetaboliteHMDB02030 (HMDB)
GARMetaboliteHMDB02022 (HMDB) glycinamide ribonucleotide
GARTProtein2618 (Entrez Gene)
  • EC 2.1.2.2
  • phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GPX 1Protein2876 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
GPX 2Protein2877 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
GPX 3Protein2878 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 3
GPX 4Protein2879 (Entrez Gene)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
GPX 6Protein257202 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
GlucoseMetaboliteHMDB00122 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB02111 (HMDB) Glutathione disulfide
HBA1Protein3039 (Entrez Gene) hemoglobin, alpha 1
HBBProtein3043 (Entrez Gene) hemoglobin, beta
HDL-CMetabolite47775 (ChEBI)
  • high-density lipoprotein cholesterol
  • Cholesterol transport
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetabolite39025 (ChEBI) high-density lipoprotein
HNO2Metabolite25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HbA1cProteinGlycated hemoglobin (Wikipedia)
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
IFNgProtein3458 (Entrez Gene) interferon, gamma
IL10Protein3458 (Entrez Gene) interferon, gamma
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
IL2Protein3558 (Entrez Gene) interleukin 2
IL4Protein3565 (Entrez Gene) interleukin 4
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
INSProtein3630 (Entrez Gene) Insulin
INSRProtein3643 (Entrez Gene) Insulin receptor
IronMetaboliteHMDB00692 (HMDB)
L-ArginineMetaboliteHMDB00517 (HMDB)
LDLMetabolite39026 (ChEBI) low-density lipoprotein
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
MATProtein4143 (Entrez Gene)
  • EC 2.5.1.6
  • Methionine adenosyltransferase
MCP1GeneProduct6347 (Entrez Gene)
  • Monocyte Chemotactic Protein 1
  • CCL2
MPOProtein4353 (Entrez Gene)
  • EC 1.11.1.7
  • Myeloperoxidase
MSR*Protein4552 (Entrez Gene)
  • EC 1.16.1.8
  • 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MTHFD1*Protein4522 (Entrez Gene)
  • EC 1.5.1.5
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1
MTHFD2Protein10797 (Entrez Gene)
  • EC 3.5.4.9
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTHFR*Protein4524 (Entrez Gene)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
  • Homozygous of (MTHFR) 677C-T variant may have enzyme activities up to 50% lower than those without the polymorphism increasing the risk of hyperhomocysteinemia
MTHFSProtein10588 (Entrez Gene)
  • EC 6.3.3.2
  • 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTR*Protein4548 (Entrez Gene)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
  • Also known as MS
MagnesiumMetaboliteHMDB00547 (HMDB)
ManganeseMetaboliteHMDB01333 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFkB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
NFkB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
NOSProtein1.14.13.39 (Enzyme Nomenclature) Nitric oxide synthase
NitrotyrosineMetaboliteHMDB01904 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
O2MetaboliteHMDB02168 (HMDB) Superoxide
O3Metabolite25812 (ChEBI) ozone
ONOO/ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
PAI-1Protein5054 (Entrez Gene) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
PLGProtein5340 (Entrez Gene)
  • EC 3.4.21.7
  • Plasminogen
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
RFKProtein55312 (Entrez Gene)
  • EC 2.7.1.26
  • riboflavin kinase
RNSMetaboliteCHEBI:62764 (ChEBI)
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
RiboflavinMetaboliteHMDB00244 (HMDB)
S-nitrosohomocysteineMetabolite3035701 (PubChem-compound)
SAA1Protein6288 (Entrez Gene) serum amyloid A1
SAA2Protein6289 (Entrez Gene) serum amyloid A2
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
SHMTProtein6470 (Entrez Gene)
  • EC 2.1.2.1
  • Serine hydroxymethyltransferase 1 (soluble)
SHMTProtein6472 (Entrez Gene)
  • EC 2.1.2.1
  • Serine hydroxymethyltransferase
SLC19A1GeneProduct6573 (Entrez Gene) solute carrier family 19 (folate transporter), member 1
SLC46A1GeneProduct113235 (Entrez Gene) solute carrier family 46 (folate transporter), member 1
SOD1Protein6647 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
SOD2Protein6648 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
SOD3Protein6649 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
SerineMetaboliteHMDB00187 (HMDB)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
TetrahydrobiopterinMetaboliteHMDB00027 (HMDB) H4B
ThrombinProtein2147 (Entrez Gene)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
ZincMetaboliteHMDB01303 (HMDB)
oxLDLMetaboliteCHEBI:60151 (ChEBI) oxidized low-density lipoprotein
p53GeneProduct7157 (Entrez Gene) tumor protein p53
sICAM-1Protein3383 (Entrez Gene) soluble intercellular adhesion molecule 1
tPAProtein5327 (Entrez Gene)
  • EC 3.4.21.68
  • plasminogen activator, tissue

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP176"
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