Sphingolipid metabolism (integrated pathway) (Mus musculus)

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365High fat dietATP3-keto-sphinganine2Ppap2aCerkSgpp1Asah1Palmitoyl-CoASgms12Sphk2Sgpl1UgcgSerine2HexadecanalSptlc1Sphk1Degs1KdsrSptlc2Ethanolamine-phosphateH2OSphingosineSphinganine2Sphinganine-1-phosphateCerS4CerS5CerS61, 4, 51C16 CerPC16DH CerPC16 SMC16 Glc-erC16DH SMC16DH GlcCerC16 GalCerC16DH GalCerSmpd1Degs2Sgms2Sphingosine-1-phosphate1-HexadecenalPpap2bPpap2cUgt8aCoA(16:0)CoA(18:0)CoA(20:0)CoA(22:0)CoA(24:0)CoA(24:1)C16DH-CerDH-CeramideDH-CeramideCerS11CerS4Cers21CoA(26:0)CoA(26:1)DH-CeramideCers3ADPSgpp2Sphk2Sphk1Sgpl1CerS4Cers21DH-CeramideCerS41CoA(14:0)C14DH-CeramideCerS5CerS611C16 Cer2CerkUgcgSmpd1Sgms1Sgms2Ugt8aC18 CerPC18DH CerPC18 SMC18 GlcCerC18DH SMC18DH GlcCerC18 GalCerC18DH GalCerC18DH-CerC18 CerC20 CerPC20DH CerPC20 SMC20 GlcCerC20DH SMC20DH GlcCerC20 GalCerC20DH GalCerC20DH-CerC20 Cer


Description

This pathway is inspired by the Lipidmaps>Sphingolipids pathway [1].

Sphingolipids are a class of lipids, which act as signal transduction and cell recognition molecules.

This pathway provides an overview of the different tail lengths (on the right), which are used to convert sphinganine to DH-ceramide.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S; ''A mouse macrophage lipidome.''; J Biol Chem, 2010 PubMed Europe PMC Scholia
  2. Lahiri S, Futerman AH; ''LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  3. Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH; ''Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.''; FEBS Lett, 2007 PubMed Europe PMC Scholia
  4. Mizutani Y, Kihara A, Igarashi Y; ''Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.''; Biochem J, 2005 PubMed Europe PMC Scholia
  5. Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M, Degen J, Dörmann P, Hoch M; ''Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.''; J Biol Chem, 2016 PubMed Europe PMC Scholia
  6. Le Stunff H, Peterson C, Thornton R, Milstien S, Mandala SM, Spiegel S; ''Characterization of murine sphingosine-1-phosphate phosphohydrolase.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  7. Merrill AH Jr; ''De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.''; J Biol Chem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124752view08:56, 8 December 2022DeSlUpdated link to LIPID MAPS PWs.
123514view11:24, 29 July 2022Conroy lipidsupdate COA IDs to lipidmaps, add missing ID
117946view10:46, 23 May 2021EweitzModified title
107209view14:30, 17 September 2019MaintBotChEBI identifier normalization
106335view08:54, 21 August 2019DeSlAdded general LipidMaps publication.
106334view08:53, 21 August 2019DeSlModified description
106269view14:17, 19 August 2019DeSlModified description
106268view14:17, 19 August 2019DeSlAnnotated specific lipids if part of tabular Data file of LipidMaps.
106267view14:05, 19 August 2019DeSlCompleted bottom part of PW.
106266view14:00, 19 August 2019DeSlAdd C26 length products.
106265view13:52, 19 August 2019DeSlAdded C22-C24 specific metabolite nodes.
106263view13:33, 19 August 2019DeSlOntology Term : 'sphingolipid biosynthetic pathway' added !
106262view13:32, 19 August 2019DeSlOntology Term : 'sphingomyelin metabolic pathway' added !
106255view13:27, 19 August 2019DeSlModified description
106252view13:25, 19 August 2019DeSlUpdated title
106251view13:24, 19 August 2019DeSlAdded specific metabolites for several chain lengths.
106249view12:55, 19 August 2019DeSlNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
1-HexadecenalMetaboliteLMFA06000088 (LIPID MAPS)
3-keto-sphinganineMetaboliteLMSP01020002 (LIPID MAPS)
ADPMetabolite456216 (ChEBI)
ATPMetabolite30616 (ChEBI)
Asah1ProteinQ9WV54 (Uniprot-TrEMBL)
C14DH-CeramideMetabolite
C16 CerMetabolite
C16 CerPMetabolite
C16 GalCerMetabolite
C16 Glc-erMetabolite
C16 SMMetaboliteSM = sphingomyelin
C16DH CerPMetabolite
C16DH GalCerMetabolite
C16DH GlcCerMetabolite
C16DH SMMetaboliteSM = sphingomyelin
C16DH-CerMetabolite
C18 CerMetabolite
C18 CerPMetabolite
C18 GalCerMetabolite
C18 GlcCerMetabolite
C18 SMMetaboliteSM = sphingomyelin
C18DH CerPMetabolite
C18DH GalCerMetabolite
C18DH GlcCerMetabolite
C18DH SMMetaboliteSM = sphingomyelin
C18DH-CerMetabolite
C20 CerMetabolite
C20 CerPMetabolite
C20 GalCerMetabolite
C20 GlcCerMetabolite
C20 SMMetaboliteSM = sphingomyelin
C20DH CerPMetabolite
C20DH GalCerMetabolite
C20DH GlcCerMetabolite
C20DH SMMetaboliteSM = sphingomyelin
C20DH-CerMetabolite
CerS1ProteinP27545 (Uniprot-TrEMBL)
CerS4Protein67260 (Entrez Gene)
CerS5ProteinQ9D6K9 (Uniprot-TrEMBL) AKA Lass5
CerS6ProteinQ8C172 (Uniprot-TrEMBL) AKA Lass6
CerkProtein223753 (Entrez Gene)
Cers2Protein76893 (Entrez Gene)
Cers3ProteinQ1A3B0 (Uniprot-TrEMBL)
CoA(14:0)Metabolite
CoA(16:0)MetaboliteLMFA07050360 (LIPID MAPS)
CoA(18:0)Metabolite15541 (ChEBI)
CoA(20:0)Metabolite15527 (ChEBI)
CoA(22:0)Metabolite24330-89-0 (CAS) AKA "Coenzyme A, S-​docosanoate"
CoA(24:0)Metabolite24305-30-4 (CAS) AKA "Coenzyme A, S-​(tetracosanoate)​"
CoA(24:1)Metabolite88362-35-0 (CAS) AKA "Coenzyme A, S-​(15Z)​-​15-​tetracosenoate"
CoA(26:0)Metabolite99313-57-2 (CAS) AKA "Coenzyme A, S-​hexacosanoate"
CoA(26:1)Metabolite
DH-CeramideMetaboliteLMSP02020000 (LIPID MAPS)
Degs1Protein13244 (Entrez Gene)
Degs2Protein70059 (Entrez Gene)
Ethanolamine-phosphateMetabolite1015 (PubChem-compound)
H2OMetabolite15377 (ChEBI)
HexadecanalMetaboliteLMFA06000088 (LIPID MAPS)
KdsrProteinQ6GV12 (Uniprot-TrEMBL) AKA Fvt1
Palmitoyl-CoAMetaboliteLMFA07050360 (LIPID MAPS) aka CoA(16:0)
Ppap2aProtein19012 (Entrez Gene)
Ppap2bProtein67916 (Entrez Gene)
Ppap2cProtein50784 (NCBI Protein)
SerineMetabolite5951 (PubChem-compound)
Sgms1Protein208449 (Entrez Gene)
Sgms2Protein74442 (Entrez Gene)
Sgpl1Protein20397 (Entrez Gene)
Sgpp1ProteinQ9JI99 (Uniprot-TrEMBL)
Sgpp2ProteinQ810K3 (Uniprot-TrEMBL)
Smpd1Protein20597 (Entrez Gene)
Sphinganine-1-phosphateMetaboliteLMSP01050002 (LIPID MAPS)
SphinganineMetaboliteLMSP01020001 (LIPID MAPS)
Sphingosine-1-phosphateMetaboliteLMSP01050001 (LIPID MAPS)
SphingosineMetaboliteLMSP01010001 (LIPID MAPS)
Sphk1ProteinQ8CI15 (Uniprot-TrEMBL)
Sphk2ProteinQ9JIA7 (Uniprot-TrEMBL)
Sptlc1Protein268656 (Entrez Gene)
Sptlc2ProteinP97363 (Uniprot-TrEMBL)
UgcgProtein22234 (Entrez Gene)
Ugt8aProtein22239 (Entrez Gene)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
3-keto-sphinganineSphinganinemim-conversion22642 (Rhea)
ADPmim-conversion15466 (Rhea)
ATPmim-conversion15466 (Rhea)
CoA(16:0)mim-conversion36540 (Rhea)
H2Omim-conversion27515 (Rhea)
Palmitoyl-CoA3-keto-sphinganinemim-conversion14762 (Rhea)
Sphinganine-1-phosphateSphinganinemim-conversion27515 (Rhea)
SphinganineSphinganine-1-phosphatemim-conversion15466 (Rhea)
Sphinganinemim-conversion36540 (Rhea) Kinetic info: [PMID:17977534]
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4690"
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