Fatty acid beta-oxidation (Homo sapiens)

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Revision as of 21:58, 28 August 2019 by Khanspers (Talk | contribs)

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Description

Complete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids, developed and curated internally by BiGCaT Bioinformatics.

This pathway was previously split into three parts plus a meta file for statistics. If you still have these you can replace all four with this single pathway.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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View approved pathways at the new wikipathways.org.

Quality Tags

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Ontology Terms

Pathway Ontology : fatty acid degradation pathway fatty acid beta degradation pathway fatty acid metabolic pathway

Disease : fatty acid metabolism

Bibliography

Reichmann H, Maltese WA, DeVivo DC; ''Enzymes of fatty acid beta-oxidation in developing brain.''; J Neurochem, 1988 PubMed Europe PMC Scholia

History

View all...

Revision	Action	Time	User	Comment
137128	view	23:09, 27 February 2025	Khanspers	Modified description
136150	view	08:24, 20 December 2024	Egonw	Added a literature reference
124923	view	22:50, 31 December 2022	Egonw	Fixed the AcylCoA identifier
116506	view	10:42, 7 May 2021	Eweitz	Modified title
113903	view	06:46, 8 December 2020	Egonw	Made more pathway nodes clickable
108064	view	13:29, 27 November 2019	DeSl	Changed textlabels to Metabolites; converted MIM-stimulation to Catalysis for enzyme linked to M1->M2 conversion.
107936	view	07:59, 12 November 2019	Mkutmon	Modified description
107778	view	02:31, 3 November 2019	Licong	Modified title
107117	view	14:19, 17 September 2019	MaintBot	ChEBI identifier normalization
106415	view	21:58, 28 August 2019	Khanspers	Modified description
105498	view	05:52, 8 August 2019	Khanspers	Modified description
98914	view	15:37, 15 October 2018	DeSl	Removed license info
98913	view	15:37, 15 October 2018	DeSl	Reverted to version '16:32, 23 June 2018' by DeSl
98815	view	21:42, 9 October 2018	Priyanka K	Modified title
97915	view	16:32, 23 June 2018	Egonw	Added a few more metabolite IDs.
97914	view	16:26, 23 June 2018	Egonw	Replaced a salt with a parent ID (from ChEBI)
94768	view	18:29, 5 October 2017	Egonw	More mim annotation.
94765	view	16:01, 5 October 2017	Egonw	Converted labels to metabolite DataNode and added mim-type annotation to conversions, and converted stimulation to catalysis.
93218	view	13:52, 4 August 2017	DeSl	Changed 3-Oxododexanoyl-CoA ID to more stereospecific one.
79783	view	15:41, 16 April 2015	Mkutmon	Fixed unconnected lines
71172	view	11:13, 11 October 2013	Mkutmon	fix unconnected lines
70676	view	19:04, 26 August 2013	Mkutmon	connected lines
68951	view	17:37, 8 July 2013	MaintBot	Updated to 2013 gpml schema
59762	view	15:10, 7 March 2013	Egonw	Converted Labels into DataNode's.
56441	view	21:35, 7 January 2013	Egonw	Added missing data source info for three data nodes.
45258	view	18:42, 7 October 2011	AlexanderPico	Ontology Term : 'fatty acid metabolism' added !
45257	view	18:42, 7 October 2011	AlexanderPico	Ontology Term : 'fatty acid metabolic pathway' added !
45256	view	18:42, 7 October 2011	AlexanderPico	Ontology Term : 'fatty acid degradation pathway' added !
45255	view	18:41, 7 October 2011	AlexanderPico	Ontology Term : 'fatty acid beta degradation pathway' added !
43430	view	15:34, 21 June 2011	AdrienDefay	Change all the TCA text label to a Pathway node with the gene ID and the correct database.
41108	view	23:22, 1 March 2011	MaintBot	Removed redundant pathway information and comments
39785	view	15:47, 18 January 2011	FerryJagers	Periodical save, work in progress
39784	view	15:37, 18 January 2011	FerryJagers	Periodical save, work in progress
39783	view	15:27, 18 January 2011	FerryJagers	Periodical save, work in progress
39782	view	14:55, 18 January 2011	FerryJagers	Periodical save, work in progress
32874	view	22:19, 16 September 2009	MaintBot	Changed type for metabolites
31971	view	13:08, 14 August 2009	MaintBot	Fixed group labels
20983	view	11:30, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:Fatty Acid Beta-oxidation BiGCaT]] moved to [[Pathway:WP143]]: Moved to stable identifier
14286	view	08:56, 22 May 2008	Pahles	grouping and connections ready, metabolites need to be checked
14155	view	15:38, 21 May 2008	Pahles	Grouping genes, connecting to reactions
14153	view	15:35, 21 May 2008	Pahles	Periodical save, work in progress
14151	view	15:25, 21 May 2008	Pahles	Periodical save, work in progress
14123	view	14:20, 21 May 2008	Pahles	partly curated
14091	view	12:03, 21 May 2008	Susan	Small adaption
13066	view	11:12, 17 May 2008	MaintBot	automated metabolite conversion
11784	view	09:24, 29 April 2008	Michiel	Resized to make GenMAPP compatible
11777	view	18:52, 28 April 2008	Evelo	Modified description
10773	view	09:54, 22 February 2008	Michiel	Position correction
10772	view	09:48, 22 February 2008	Michiel	Modified description
10771	view	09:47, 22 February 2008	Michiel	Specify description

External references

DataNodes

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Name	Type	Database reference
(S)-3-Hydroxybutanoyl-CoA	Metabolite	CHEBI:15453 (ChEBI)
(S)-3-Hydroxydecanoyl-CoA	Metabolite	CHEBI:28325 (ChEBI)
(S)-3-Hydroxydodexanonyl-CoA	Metabolite
(S)-3-Hydroxyhexadecanoyl-CoA	Metabolite	CHEBI:27402 (ChEBI)
(S)-3-Hydroxyoctanoyl-CoA	Metabolite	CHEBI:28632 (ChEBI)
(S)-3-Hydroxytetradecanoyl-CoA	Metabolite	CHEBI:27466 (ChEBI)
2-trans-4-cis-decadienoyl-CoA	Metabolite	CHEBI:29119 (ChEBI)
2-trans-dodecenoyl-CoA	Metabolite	CHEBI:15471 (ChEBI)
3-Oxo-octanoyl-CoA	Metabolite	CHEBI:28264 (ChEBI)
3-Oxocanoyl-CoA	Metabolite
3-Oxododexanoyl-CoA	Metabolite	11966169 (PubChem-compound)
3-Oxohexanoyl-CoA	Metabolite	CHEBI:27648 (ChEBI)
3-Oxopalmitoyl-CoA	Metabolite	CHEBI:15491 (ChEBI)
3-trans-decenoyl-CoA	Metabolite	CHEBI:29126 (ChEBI)
4-cis-dexeboyl-CoA	Metabolite
ACADL	GeneProduct	33 (Entrez Gene)
ACADM	GeneProduct	34 (Entrez Gene)
ACADS	GeneProduct	35 (Entrez Gene)
ACADVL	GeneProduct	37 (Entrez Gene)
ACAS2	GeneProduct	55902 (Entrez Gene)
ACAT1	GeneProduct	38 (Entrez Gene)
ACSL1	GeneProduct	2180 (Entrez Gene)
ACSL3	GeneProduct	2181 (Entrez Gene)
ACSL4	GeneProduct	2182 (Entrez Gene)
ACSL5	GeneProduct	51703 (Entrez Gene)
ACSL6	GeneProduct	23305 (Entrez Gene)
Acetoacetyl-CoA	Metabolite	1420-36-6 (CAS)
Acetyl-CoA	Metabolite	72-89-9 (CAS)
Acyl-CoA	Metabolite	9029-97-4 (CAS)
Butanoyl-CoA	Metabolite	CHEBI:15517 (ChEBI)
CHKB	GeneProduct	1120 (Entrez Gene)
CPT1A	GeneProduct	1374 (Entrez Gene)
CPT1B	GeneProduct	1375 (Entrez Gene)
CPT2	GeneProduct	1376 (Entrez Gene)
CRAT	GeneProduct	1384 (Entrez Gene)
DCI	GeneProduct	1632 (Entrez Gene)
DECR1	GeneProduct	1666 (Entrez Gene)
DLD	GeneProduct	1738 (Entrez Gene)
Decanoyl-CoA	Metabolite	CHEBI:28493 (ChEBI)
Dihydroxyacetone Phosphate	Metabolite	57-04-5 (CAS)
Dxotetradecanoyl-CoA	Metabolite
ECHS1	GeneProduct	1892 (Entrez Gene)
Fatty Acid	Metabolite	CHEBI:35366 (ChEBI)
GCDH	GeneProduct	2639 (Entrez Gene)
GK2	GeneProduct	2712 (Entrez Gene)
GK	GeneProduct	2710 (Entrez Gene)
GPD2	GeneProduct	2820 (Entrez Gene)
Glutarate	Metabolite	743 (PubChem-compound)
Glutaryl-CoA	Metabolite	15524 (ChEBI)
Glyceraldehyde-3-Phosphate	Metabolite	591-57-1 (CAS)
Glycerol	Metabolite	56-81-5 (CAS)
HADHA	GeneProduct	3030 (Entrez Gene)
HADHB	GeneProduct	3032 (Entrez Gene)
HADHSC	GeneProduct	3033 (Entrez Gene)
Hexanoyl-CoA	Metabolite	CHEBI:27540 (ChEBI)
L-Glycerol-3-Phosphate	Metabolite	CHEBI:15978 (ChEBI)
LIPC	GeneProduct	3990 (Entrez Gene)
LIPE	GeneProduct	3991 (Entrez Gene)
LIPF	GeneProduct	8513 (Entrez Gene)
LPL	GeneProduct	4023 (Entrez Gene)
Lauroyl-CoA	Metabolite	6244-92-4 (CAS)
Linoleoyl-CoA	Metabolite	40757-80-0 (CAS)
Myristoyl-CoA	Metabolite	CHEBI:15532 (ChEBI)
Octaoyl-CoA	Metabolite
PNPLA2	GeneProduct	57104 (Entrez Gene)
Palmitoyl-CoA	Metabolite	CHEBI:15525 (ChEBI)
SLC25A20	GeneProduct	788 (Entrez Gene)
TCA cycle	Pathway	WP78 (WikiPathways)
TPI1	GeneProduct	7167 (Entrez Gene)
Trans-Dec-2-enoyl-CoA	Metabolite	CHEBI:10723 (ChEBI)
Trans-Hex-2-enoyl-CoA	Metabolite	CHEBI:28706 (ChEBI)
Trans-Hexadecanoyl-CoA	Metabolite
Trans-Oct-2-enoyl-CoA	Metabolite	CHEBI:27537 (ChEBI)
Trans-Tetradex-2-enoyl-CoA	Metabolite
Triacylglycerol	Metabolite	CHEBI:17855 (ChEBI)
cis,cis-3,6-Dodecadienoyl-CoA	Metabolite	CHEBI:28002 (ChEBI)
trans,cis-Lauro-2,6-dienoyl-CoA	Metabolite	CHEBI:28387 (ChEBI)