Toll-like receptor signaling related to MyD88 (Homo sapiens)
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Description
This pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflammation in the body and in the cancerous cells. TLR signaling pathways are usually connected with MyD88 dependent pathways and MyD88 independent pathways. TLR pathways that involve MyD88 dependent pathways such as this one involve IRAK complexes. The finding of TLR or NFkB genes within the body usually correlates with breast cancer within the person.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
Quality Tags
Ontology Terms
Bibliography
- Resler AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, Madeleine MM; ''Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.''; BMC Cancer, 2013 PubMed Europe PMC Scholia
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Annotated Interactions
No annotated interactions