Purine metabolism (Homo sapiens)
From WikiPathways
Description
Overview of purine metabolism and related diseases. Disorders resulting from an enzyme defect are highlighted in pink, metabolic markers are highlighted in red. Arrows indicate the directionality of chemical conversions.
On the right, the biosynthesis of IMP is depicted in more detail (adapted from: https://en.wikipedia.org/wiki/Purine_metabolism). The color scheme for this part of the pathway is as follows: enzymes(black), coenzymes(light orange), regular substrates/metabolites(blue), additional substrates(dark green), metal ions(turquoise), inorganic molecules(light purple).
This pathway was inspired by Chapter 41 of the book of Blau (ISBN 3642403360 (978-3642403361)).
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Saving...Bibliography
- Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
- Blau, N., Duran, M., Gibson, K.M., Dionisi-Vici, C.; ''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 11 and 41''; ISBN 978-3-642-40337-8, 2014
History
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External references
DataNodes
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Annotated Interactions
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| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| 2'-Deoxyadenosine | 2'-deoxyinosine | mim-conversion | 28191 (Rhea)  | |
| 2'-Deoxyadenosine | Adenine | mim-conversion | 27743 (Rhea) | |
| 2'-deoxyinosine | Hypoxanthine | mim-conversion | 27751 (Rhea) | |
| 2-Deoxyguanosine | Guanine | mim-conversion | 27739 (Rhea) | |
| 2-Deoxyguanosine | dGMP | mim-conversion | 19202 (Rhea) | |
| 2-Deoxyguanosine | mim-conversion | 19203 (Rhea) | ||
| ADP | ATP | mim-conversion | 30657 (Rhea) | |
| ADP | dADP | mim-conversion | 28036 (Rhea) | |
| AICARP | FAICARP | mim-conversion | 22193 (Rhea) | |
| AMP | ADP | mim-conversion | 11462 (Rhea) | |
| AMP | Adenosine | mim-conversion | 29376 (Rhea) | |
| AMP | IMP | mim-conversion | 14778 (Rhea) | |
| Adenine | AMP | mim-conversion | 16611 (Rhea) | |
| Adenosine | Adenine | mim-conversion | 18670 (Rhea) | |
| Adenosine | Inosine | mim-conversion | 24409 (Rhea) | |
| FAICARP | IMP | mim-conversion | 18447 (Rhea) | |
| GDP | GTP | mim-conversion | 29865 (Rhea) | |
| GDP | dGDP | mim-conversion | 28032 (Rhea) | |
| GMP | GDP | mim-conversion | 20781 (Rhea) | |
| GMP | Guanosine | mim-conversion | 27715 (Rhea) | |
| Guanine | mim-conversion | 14666 (Rhea) | ||
| Guanine | mim-conversion | 25426 (Rhea) | ||
| Guanosine | Guanine | mim-conversion | 13234 (Rhea) | |
| Hypoxanthine | Xanthine | mim-conversion | 24671 (Rhea) | |
| Hypoxanthine | mim-conversion | 17975 (Rhea) | ||
| IMP | Inosine | mim-conversion | 27719 (Rhea) | |
| IMP | S-AMP | mim-conversion | 15754 (Rhea) | |
| IMP | XMP | mim-conversion | 11709 (Rhea) | |
| ITP | IMP | mim-conversion | 29400 (Rhea) | |
| Inosine | Hypoxanthine | mim-conversion | 16658 (Rhea) | |
| S-AMP | AMP | mim-conversion | 16854 (Rhea) | |
| SAICARP | AICARP | mim-conversion | 23921 (Rhea) | |
| XMP | GMP | mim-conversion | 18302 (Rhea) | |
| XMP | Xanthosine | mim-conversion | 28531 (Rhea) | |
| Xanthine | Urate | mim-conversion | 16670 (Rhea) | |
| Xanthosine | Xanthine | mim-conversion | 27639 (Rhea) | |
| dADP | dAMP | mim-conversion | 23102 (Rhea) | |
| dADP | dATP | mim-conversion | 27675 (Rhea) | |
| dAMP | 2'-Deoxyadenosine | mim-conversion | 29372 (Rhea) | |
| dGDP | dGMP | mim-conversion | 12699 (Rhea) | |
| dGDP | dGTP | mim-conversion | 27691 (Rhea) |
