CAMKK2 pathway (Homo sapiens)

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CAMKK217LabelCAMKK2 pathwayNFATC2MAP1LC3AFIS1CALM1IFI44LMAFCa2+DRP1HO-1STIM1VCAM-1163515, 352GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins21ERMAPRPTOR27NEDD4LCauleprin28ABCA1CASP717HK2MTOR8S2448CYB5R3CAMK134S100A8ACACA1S79HK2ARHGEF730S516 EPORFOXO3AS3186S321CCNE1PFKFB2TMEM176BIsorhamnetin24Adropin4CCL5Hydrogen sulphide42TRPV4EP30038S1834 KDRSFI1WDR35Ramipril36SMC11NRF2MAP1LC3BCCND1NOS3 11S1177SLCO3A1MAPK14 40Y122TSPAN33NLRP1WFS112MAP1LC3AMAPK129MX2Homocysteine sulfinic acid40FAM132aCD28KEAP1MID1Apigenin22IL15RPS6KB1HMBSEstrogen20CD28CAMK4P13RELA33VCAM-1OASLCTSEMetabolitesSPINT1NOS110SREBF1CDH1GIT130CASP917SQSTM131MAP1LC3BRASGRP1Withdrawal of essential amino acids45PPAP2AEugenol23IRGCGlyceollin37RPS6PAK1 43CREB138HFEQuercetin26WFS1PCK2Hypoxia14CDC25AOxytocin39SELLTSPAN8CHRM315TREM3EIF4EBP1T37S659T46SLC2A4ATP1B2PLAC8ICAM13GATMGDH1 7Poly unsaturated fatty acids25TNFαCAMKK221, 44TBXTLaminar shear stress38AQP1CASP317ACACARAC143IRS-16, 37S639S636CXCL11GCKSPIRE1PARP1Pulsed electric field41CCR9HDCA413EPORBupivacine33FAM20CHMOX1Betulinic acid11INN2CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 19T642 ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC19SIRT1 18AKTT30832S473RPS6KB1T389AutophagyAnkosis Anaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA221T172ULK1S555 S757317ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK3TSC2299T1462 PRKCA5T639 NRF2NUCYNUCYCytoplasmKnockoutMetabolitesActivationAnti-apoptotic mRNA


Description

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities. CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134958view09:42, 30 July 2024EgonwAdded datanode types based on the xref datasource
134666view14:27, 25 July 2024Ash iyerupdate metabolites annotation and added grahical elements.
134665view14:11, 25 July 2024Ash iyerchanging datanodes to graphical elements.
134664view14:06, 25 July 2024Ash iyeradded missing annotation on datanodes.
134659view10:40, 25 July 2024Ash iyeradd missing annotation for datanodes
134658view10:20, 25 July 2024Ash iyerModified description
134646view08:55, 24 July 2024EgonwRemoved labels that were listed as identifier without datasource
126535view09:44, 29 May 2023EgonwTyped datanodes
124683view07:26, 24 November 2022Rex D A B
121708view04:43, 26 February 2022EweitzUse gene symbol
117669view11:58, 22 May 2021EweitzModified title
113833view08:50, 30 November 2020Fehrhartconnected some of the unconnected lines
113771view18:21, 19 November 2020KhanspersModified description
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCA1GeneProductABCA1
ACACAGeneProductACACA
ACACAProteinNP_942131.1 (NCBI Protein)
AHSPGeneProductAHSP
AKTProteinNP_001014431.1 (NCBI Protein)
AQP1GeneProduct
ARHGEF7GeneProduct8874 (Entrez Gene)
ASNSGeneProductASNS
ATP10DGeneProductATP10D
ATP1B2GeneProductATP1B2
AdropinMetaboliteAdropin (HMDB)
ApigeninMetaboliteApigenin (HMDB)
Betulinic acidMetaboliteBetulinic acid (HMDB)
BupivacineMetaboliteBupivacine (HMDB)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CAR1GeneProductCAR1
CASP3GeneProduct836 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CCL5GeneProductCCL5
CCND1GeneProductCCND1
CCND2GeneProductCCND2
CCNE1GeneProductCCNE1
CCR9GeneProductCCR9
CD28GeneProductCD28
CDC25AGeneProductCDC25A
CDH1GeneProductCDH1
CHRM3GeneProduct1131 (Entrez Gene)
CPOXGeneProductCPOX
CREB1GeneProduct1385 (Entrez Gene)
CRTC2GeneProductCRTC2
CTSEGeneProductCTSE
CXCL11GeneProductCXCL11
CYB5R3GeneProductCYB5R3
Ca2+
CauleprinMetaboliteCauleprin (HMDB)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProductEPOR
ERMAPGeneProductERMAP
EstrogenGeneProduct
EugenolMetaboliteEugenol
FAM132aGeneProductFAM132a
FAM20CGeneProductFAM20C
FASNGeneProductFASN
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GALNT9GeneProductGALNT9
GATMGeneProductGATM
GCKGeneProductGCK
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteGlyceollin (Wikidata)
HDCA4GeneProduct9759 (Entrez Gene)
HFEGeneProductHFE
HIF1AGeneProductHIF1A
HK1GeneProduct
HK1GeneProductHK1
HK2GeneProduct
HK2GeneProductHK2
HMBSGeneProductHMBS
HMOX1GeneProduct
HO-1GeneProductHO-1
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideGeneProduct
HypoxiaHypoxia
ICAM1GeneProduct3383 (Entrez Gene)
IFI44LGeneProductIFI44L
IL15GeneProductIL15
INNGeneProduct
IRGCGeneProductIRGC
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
KDRGeneProductKDR
KEAP1GeneProductKEAP1
KLF1GeneProductKLF1
Laminar shear stressLaminar shear stress (Other)
MAFGeneProduct4094 (Entrez Gene)
MAMDC2GeneProductMAMDC2
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3AGeneProductMAP1LC3A
MAP1LC3BGeneProductMAP1LC3B
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MID1GeneProductMID1
MS4A3GeneProductMS4A3
MT1GeneProductMT1
MTORGeneProduct2475 (Entrez Gene)
MX2GeneProductMX2
MetabolitesGeneProductMetabolites
NEDD4LGeneProductNEDD4L
NFATC2GeneProduct4773 (Entrez Gene)
NLRP1GeneProductNLRP1
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct4780 (Entrez Gene)
NRF2GeneProductNRF2
OASLGeneProductOASL
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (NCBI Protein)
PARP1GeneProductPARP1
PCK2GeneProductPCK2
PFKFB2GeneProductPFKFB2
PFKFB3GeneProductPFKFB3
PLAC8GeneProductPLAC8
PPAP2AGeneProductPPAP2A
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
Pulsed electric fieldGeneProduct
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RASGRP1GeneProductRASGRP1
RELAGeneProduct5970 (Entrez Gene)
RHAGGeneProductRHAG
RHDGeneProductRHD
RPS6KB1GeneProductRPS6KB1
RPS6GeneProductRPS6
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
S100A8GeneProductS100A8
SELLGeneProductSELL
SFI1GeneProductSFI1
SIRT1 GeneProduct23411 (Entrez Gene)
SLC25A21GeneProductSLC25A21
SLC2A1GeneProductSLC2A1
SLC2A4GeneProductSLC2A4
SLC38A5GeneProductSLC38A5
SLCO3A1GeneProductSLCO3A1
SMC1GeneProduct8243 (Entrez Gene)
SPINT1GeneProductSPINT1
SPIRE1GeneProductSPIRE1
SQSTM1GeneProduct8878 (Entrez Gene)
SREBF1GeneProductSREBF1
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TBXTGeneProductTBXT
TMEM176BGeneProductTMEM176B
TNFαGeneProductTNFα
TREM3GeneProductTREM3
TRPV4GeneProductTRPV4
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
TSPAN33GeneProductTSPAN33
TSPAN8GeneProductTSPAN8
TheasinensinsMetabolite
ULK1GeneProductULK1
VCAM-1GeneProductVCAM-1
WDR35GeneProductWDR35
WFS1GeneProduct7466 (Entrez Gene)
WFS1GeneProductWFS1
Withdrawal of essential amino acidsGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4874"
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