Diclofenac metabolic pathway (Homo sapiens)

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14'-hydroxydiclofenacdiclofenac5-hydroxydiclofenac3'-HydroxydiclofenacCYP2C9CYP2B6CYP2C84',5-DihydroxydiclofenacMetaboliteCYP2C18CYP2C19CYP2C9


Description

CYP metabolism of the diclofenac drug (a NSAID), commonly used to treat pain and inflammatory diseases.

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Ontology Terms

 

Bibliography

  1. Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J; ''Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.''; Biochem Pharmacol, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117698view12:20, 22 May 2021EweitzModified title
113831view08:41, 30 November 2020FehrhartOntology Term : 'Disease' added !
113747view13:12, 19 November 2020DeSlUpdated description.
92287view12:39, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
73891view09:56, 2 March 2014EgonwModified description
71432view19:03, 17 October 2013MaintBotupdated data sources
70516view12:45, 9 August 2013EgonwAdded a missing metabolite identifier.
70515view12:43, 9 August 2013EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
62552view23:34, 29 April 2013AlexanderPicoModified representation of group
62341view22:23, 27 April 2013MaintBotModified categories
62324view15:10, 27 April 2013EgonwAdded Uniprot IDs
62323view15:02, 27 April 2013EgonwReadded the lit ref that was removed by the previous applet edit.
62320view14:36, 27 April 2013EgonwCompleted all reactions from the paper.
62317view14:04, 27 April 2013EgonwAdded a name for the CYP product.
62316view13:42, 27 April 2013EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3'-HydroxydiclofenacMetabolite112230 (PubChem-compound)
4',5-DihydroxydiclofenacMetabolite3052567 (PubChem-compound)
4'-hydroxydiclofenacMetabolite116545 (PubChem-compound)
5-hydroxydiclofenacMetabolite3052566 (PubChem-compound)
CYP2B6ProteinP20813 (Uniprot-TrEMBL)
CYP2C18ProteinP33260 (Uniprot-TrEMBL)
CYP2C19ProteinP33261 (Uniprot-TrEMBL)
CYP2C8ProteinP10632 (Uniprot-TrEMBL)
CYP2C9ProteinQ6IRV8 (Uniprot-TrEMBL)
MetaboliteMetabolite10065052 (PubChem-compound)
diclofenacMetabolite3033 (PubChem-compound)

Annotated Interactions

No annotated interactions

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