DNA replication (Caenorhabditis elegans)

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Cdt1ATPCdt1Mcm3Phosphorylated Cdc6RFC Heteropentamer:RNA primer-DNA primerOrc2Mcm7Phosphorylation of Mcm 2-7 complexMcm 4,6,7 trimer forms and associates with the replication forkRFC40Cdc6PrimaseCdc6Ubiquitinated Cdc6dCTPOrc3Cdc6DNA PolymeraseOriginRNA primer-DNA primerOrc4Orc complexDegraded by proteasome in cytosolRFC Heteropentamer:RNA primer-DNA primer:p180Processive complexRFC140Orc complexDNA polymerase alpha: primase: origin complexATPRNA PrimerGemininRNA primer-DNA primerDegraded by proteasome in cytosolMcm10ATPOrc5Orc5Cdt1Mcm4ADPMcm7Orc2Orc4DNA polymerase alpha: primase: origin complexUbiquitinMcm4Ubiquitinated Orc1ADP5. Leading/lagging strand synthesisOrc3Phosphorylated Orc1dGTPMcm54. Switching of origins to post-replicative stateOrc3UTPdATPPre-replicative complexMcm3GTP2. Activation of the pre-replicative complexCdt1RFC36Pre-replicative complexRFC37ATPaMcm2RFC38Mcm5Orc complexOrc1dUTPp49p58RNA primer-DNA primer:origin duplex:PCNA1. Assembly of the pre-replicative complexMcm6Cdt1Orc complexMcm6Cdc6Orc2Mcm2Orc ComplexOrc2p70PCNA homotrimerCTPOrc5UbiquitinOrc33. DNA replication initiationCDK2GMNNorc-2POLD3F33H2.5div-1Y47D3A.29pri-2rfc-3mcm-6rfc-1F34D10.2ORC6Lubq-1Y47D3A.28POLD2RPA2CDT1CDC7POLD4RPA3ARPAORC4Lmcm-4ORC3Lcdc-6PCNARPA4RPA1ORC5Lmcm-2mcm-7rfc-2ubq-2CDC46ASKF08B4.5F10C2.4RFC4Y39A1A.12mcm-3pri-1


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct
ATPMetaboliteCHEBI:15422 (ChEBI)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct
CDK2GeneProduct
CDT1GeneProduct
CTPMetaboliteCHEBI:17677 (ChEBI)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct
GTPMetaboliteCHEBI:15996 (ChEBI)
ORC3LGeneProduct
ORC4LGeneProduct
ORC5LGeneProduct
ORC6LGeneProduct
PCNAGeneProduct
POLD2GeneProduct
POLD3GeneProduct
POLD4GeneProduct
RFC4GeneProduct
RPA1GeneProduct
RPA2GeneProduct
RPA3GeneProduct
RPA4GeneProduct
UTPMetaboliteCHEBI:15713 (ChEBI)
UbiquitinProtein
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
dATPMetaboliteCHEBI:16284 (ChEBI)
dCTPMetaboliteCHEBI:16311 (ChEBI)
dGTPMetaboliteCHEBI:16497 (ChEBI)
dUTPMetaboliteCHEBI:17625 (ChEBI)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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