Retinol metabolism (Homo sapiens)

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1, 2all-trans-retinyl estersLRATbeta-CaroteneBCDO1RPE6511-cis-retinol9-cis-retinoateDHRS411-cis-retinyl palmitate9-cis-retinolCP26ACP2W1CP3A711-cis-retinyl-palmitate hydrolaseSDR16C5DHRS9Aldehyde oxidase18-hydroxy RA11-cis-retinyl tetradecanoateAWAT29-cis-retinalCP1A1Aldehyde oxidaseRetinal dehydrogenase 1PNPL4RDH13all-trans-retinoateall-trans-retinolAWAT2CP2A64-oxo RAall-trans-retinalADH1A11-cis retinal4-hydroxy RAIodopsinRDH123, 4Retinal dehydrogenase 15RDH13CP1A1CP26ACP2A6CP3A7CP1A1CP26ACP2A6CP3A7


Description

This pathway describes the metabolism of retinoid into subclasses, starting at beta-carotene, ending in different subclasses of retinyl esters, types of retinoic acds and oxidized species.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Blaner WS, Prystowsky JH, Smith JE, Goodman DS; ''Rat liver retinyl palmitate hydrolase activity. Relationship to cholesteryl oleate and triolein hydrolase activities.''; Biochim Biophys Acta, 1984 PubMed Europe PMC Scholia
  2. Blaner WS, Das SR, Gouras P, Flood MT; ''Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells.''; J Biol Chem, 1987 PubMed Europe PMC Scholia
  3. Travis GH, Golczak M, Moise AR, Palczewski K; ''Retinol Metabolism''; Kegg,
  4. Li Y, Wongsiriroj N, Blaner WS; ''The multifaceted nature of retinoid transport and metabolism.''; Hepatobiliary Surg Nutr, 2014 PubMed Europe PMC Scholia
  5. Arne JM, Widjaja-Adhi MAK, Hughes T, Huynh KW, Silvaroli JA, Chelstowska S, Moiseenkova-Bell VY, Golczak M; ''Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2.''; J Lipid Res, 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
122585view10:03, 18 April 2022EweitzModified description
122547view01:42, 15 April 2022EweitzModified title
122215view07:00, 16 March 2022RvanrosmeulenAdded more info in the description
122167view14:27, 14 March 2022RvanrosmeulenAdded pathway datanodes
122160view13:55, 14 March 2022RvanrosmeulenUpdated the layout of the pathway
122159view12:52, 14 March 2022DeSlOntology Term : 'classic metabolic pathway' added !
122142view11:06, 14 March 2022RvanrosmeulenOntology Term : 'signaling pathway' added !
122141view11:05, 14 March 2022RvanrosmeulenOntology Term : 'compound eye retinal cell' added !
122140view11:05, 14 March 2022RvanrosmeulenOntology Term : 'Pathway Ontology' added !
122139view11:04, 14 March 2022RvanrosmeulenModified title
122138view10:44, 14 March 2022Rvanrosmeulenadded specification on 11-cis-retinol conversion
122137view09:59, 14 March 2022RvanrosmeulenUpdated HMDB ID structures
122130view12:43, 12 March 2022RvanrosmeulenUpdates description, added literature, changed geneproduct annotations in protein annotations, added correct annotations for three proteins
122109view00:44, 11 March 2022DeSlSmall layout changes
122020view10:11, 9 March 2022RvanrosmeulenAdded literature and another description
121609view08:33, 22 February 2022RvanrosmeulenAdded extra end product conversion all-trans-retinoate
121600view18:10, 21 February 2022AndraOntology Term : 'retinol metabolic pathway' added !
121486view10:09, 18 February 2022RvanrosmeulenAdded abbreviations
121330view10:06, 15 February 2022RvanrosmeulenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
11-cis retinalMetaboliteQ17002962 (Wikidata)
11-cis-retinolMetaboliteCHEBI:16302 (ChEBI)
11-cis-retinyl palmitateMetaboliteCHEBI:16254 (ChEBI)
11-cis-retinyl tetradecanoateMetaboliteCHEBI:138676 (ChEBI)
11-cis-retinyl-palmitate hydrolaseProteinEC3.1.1.63 (BRENDA)
18-hydroxy RAMetaboliteHMDB0012452 (HMDB)
4-hydroxy RAMetaboliteQ27132808 (Wikidata)
4-oxo RAMetaboliteCHEBI:80656 (ChEBI)
9-cis-retinalMetaboliteCHEBI:78273 (ChEBI)
9-cis-retinoateMetaboliteCHEBI:78630 (ChEBI)
9-cis-retinolMetaboliteCHEBI:78272 (ChEBI)
ADH1AProteinP07327 (Uniprot-TrEMBL)
AWAT2ProteinQ6E213 (Uniprot-TrEMBL)
Aldehyde oxidaseProteinQ06278 (Uniprot-TrEMBL)
BCDO1ProteinQ9HAY6 (Uniprot-TrEMBL)
CP1A1ProteinP04798 (Uniprot-TrEMBL)
CP26AProtein043174 (Uniprot-TrEMBL)
CP2A6ProteinP11509 (Uniprot-TrEMBL)
CP2W1ProteinQ8TAV3 (Uniprot-TrEMBL)
CP3A7ProteinP24462 (Uniprot-TrEMBL)
DHRS4 ProteinQ9BTZ2 (Uniprot-TrEMBL)
DHRS9ProteinQ9BPW9 (Uniprot-TrEMBL)
IodopsinMetaboliteCHEBI:5949 (ChEBI)
LRATProteinO95237 (Uniprot-TrEMBL)
PNPL4ProteinP41247 (Uniprot-SwissProt)
RDH12ProteinQ96NR8 (Uniprot-TrEMBL)
RDH13 ProteinQ8NBN7 (Uniprot-TrEMBL)
RDH13ProteinQ8NBN7 (Uniprot-TrEMBL)
RPE65 ProteinQ16518 (Uniprot-TrEMBL)
Retinal dehydrogenase 1ProteinP00352 (Uniprot-TrEMBL)
SDR16C5ProteinQ8N3Y7 (Uniprot-TrEMBL)
all-trans-retinalMetaboliteCHEBI:17898 (ChEBI)
all-trans-retinoateMetaboliteCHEBI:35291 (ChEBI)
all-trans-retinolMetaboliteCHEBI:17336 (ChEBI)
all-trans-retinyl estersMetaboliteCHEBI:63410 (ChEBI)
beta-CaroteneMetaboliteHMDB0000561 (HMDB)

Annotated Interactions

No annotated interactions

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