Neolacto series sphingolipid metabolism (Homo sapiens)

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1, 2NEU2ST3GAL4B4GALT1B3GNT5B4GALT4H1 glycolipid, type II antigenLc3CerNAGAFUT2B4GALT3nLc6Ceri antigen FUCA1nLc4CernLc5CerFUT5Sialyl LeXSSEA-1, Lex-5Type II A antigenSialosylparaglobosideNeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-CerFUT1LacCerB3GNT5


Description

Ganglio- series of glycosphingolipids, biosynthesis

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Quality Tags

Ontology Terms

 

Bibliography

  1. Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
  2. ''Handbook of Glycosyltransferases and Related Genes''; doi.org/10.1007/978-4-431-67877-9, 2002
  3. Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134478view01:04, 22 July 2024EweitzFix truncated label in node
134477view01:04, 22 July 2024EweitzFix truncated labels in nodes, improve node alignment
124624view14:24, 17 November 2022Conroy lipidsanother metabolight
124623view13:47, 17 November 2022Conroy lipidsa couple more steps from sphingomap- no synthesis data available in rhea
124619view15:52, 16 November 2022Conroy lipidsOntology Term : 'glycosphingolipid metabolic pathway' added !
124618view15:52, 16 November 2022Conroy lipidsOntology Term : 'lipid metabolic pathway' added !
124617view15:52, 16 November 2022Conroy lipidsOntology Term : 'PW:0000164' removed !
124616view15:34, 16 November 2022Conroy lipids
124615view15:22, 16 November 2022Conroy lipidsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
B3GNT5GeneProductQ9BYG0 (Uniprot-TrEMBL)
B4GALT1GeneProductP15291 (Uniprot-TrEMBL)
B4GALT3GeneProductO60512 (Uniprot-TrEMBL)
B4GALT4GeneProductO60513 (Uniprot-TrEMBL)
FUCA1GeneProductP04066 (Uniprot-TrEMBL)
FUT1GeneProductP19526 (Uniprot-TrEMBL)
FUT2GeneProductQ10981 (Uniprot-TrEMBL)
FUT5GeneProductQ11128 (Uniprot-TrEMBL)
H1 glycolipid, type II antigenMetaboliteLMSP0505AD00 (LIPID MAPS)
LacCerMetaboliteLMSP0501AB00 (LIPID MAPS)
Lc3CerMetaboliteLMSP0504AA00 (LIPID MAPS)
NAGAGeneProductP17050 (Uniprot-TrEMBL)
NEU2GeneProductQ9Y3R4 (Uniprot-TrEMBL)
NeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-CerMetaboliteLMSP0601EG00 (LIPID MAPS)
SSEA-1, Lex-5MetaboliteLMSP0505AB00 (LIPID MAPS)
ST3GAL4GeneProductQ11206 (Uniprot-TrEMBL)
SialosylparaglobosideMetaboliteLMSP0601EF00 (LIPID MAPS)
Sialyl LeXMetaboliteLMSP0601EE00 (LIPID MAPS)
Type II A antigenMetaboliteLMSP0505AF00 (LIPID MAPS)
nLc4CerMetaboliteLMSP0505AA00 (LIPID MAPS) ChEBI 17292, Smap 8
nLc5CerMetaboliteLMSP0505AK00 (LIPID MAPS)
nLc6Cer i antigen MetaboliteLMSP0505AL00 (LIPID MAPS)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
H1 glycolipid, type II antigennLc4Cermim-conversion48225 (Rhea)
LacCerLc3Cermim-conversion13906 (Rhea)
Lc3CernLc4Cermim-conversion31500 (Rhea)
SialosylparaglobosidenLc4Cermim-conversion47853 (Rhea)
Type II A antigenH1 glycolipid, type II antigenmim-conversion48213 (Rhea)
nLc4CerH1 glycolipid, type II antigenmim-conversion48305 (Rhea)
nLc4CerSSEA-1, Lex-5mim-conversion48333 (Rhea)
nLc4CerSialosylparaglobosidemim-conversion18914 (Rhea)
nLc4CernLc5Cermim-conversion23005 (Rhea)
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