AXL signaling (Homo sapiens)

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Colorectal CancerTranscription factorsLung adenocarcinomasTumor invasion/migrationCollagenEMTTransmembrane proteinImmune supressionProliferationMatrix metalloproteasesThrombosisOsteosarcoma ChemokinesTumor progressionEGFR nuclear translocation mediatorsNUCLEUScell migration and invasionTranscriptional regulator PLASMA MEMBRANERegulatory T cells(Tregs)Bone morphogenicproteinsCellular senescenceInflammationCPLiver Inflammation, Steatohepatitis, and FibrosisDormacy cell survivalBECN1ZEB1NLRP3ANXA2AXIN2LEF1ATG5CASP1MYCFN1MAP1LC3BCCND1TGFBR22147MSNTGF4GLI2CALD1TGFB2TMEM132ASMOADAM11GLI3NRG1TGFB1I1SPARCBMP8BAKT3SNAI3MITFAHNAK2VAV136PBMP6EGFRBMP7Y1101Y11735, 18CDK441CAV2SP132CDK641CD274MYC CXCL16TGFB1TMEFF1LINC00526CXCR6BMP8AGLI1LYN RPS6KA1BCL2T359S36314FOXP3BIRC5TGFB2COL3A1CHEK114LIGHTTFTGFBR2TP53CCR2YESDKK3SERPINE1CCL2ADGRE1VIMAXLY860Y779Y81524, 29, 39SOCS1ACOX1NFKBIA51MKI67CTLA4GSK3B S910, 17, 33, 34STAT124PBCL2L1TGFB1MAPK8P23, 27, 53RPS6S9S25328, 44S263MMP9CCND1CPT1AATF2P23TNFANGPT2CASP342CTNNB1S552CD36CCNE1 SOCS3MERTK37PCDKN2AVCAM-1PI3KP12, 20, 49MAP2K22, 19MAP2K12MAPK3T202Y20413, 25, 44MAPK1447PBcl-2MTOR38PTWISTKDR3IRS-1VEGFA3SNAI1ACTA2CTNNB1JUNP23PDK1LTBCAV1TNS246Y483CHUKP30, 43BIRC5MAPK923, 27PTIMP1AKT1T3086, 37, 48S473SLUGPARP1MAPK18, 14, 40T185Y187MET22ACTA1FOXO17PIL1BFOXO1RPS6KB1GAS626PTK250PCOL1A1PAK131PSNAI2SCDELMO129NFKBIAP30CDKN1APTPN113PSNAILMCP1COL1A1CYR61 KRASAutophagyPPARGAnti-apoptotic Signaling Cell migrationMMP2AngiogenesisCHEK114S280MDM441S314MDM2MDM4DAPKS3084CIP2A4ApoptosisCYTOPLASMCDH1Cell survivalRELA37RELA35, 42S529RAC1SRC9, 15, 45Y416SMAD327S213IL1BIL-18CTNNB152EGFRPRKACAFASFLT1COL3A1LEGENDLigandReceptorLeads to unknown mechanismPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisS100A10 SOCS3SOCS1ProteinProtein-Protein InteractionProteinmRNAACTA2STAT311, 16CPNUNUPM


Description

Axl is a transmembrane protein comes under TAM (Tyro3,Axl and Mertk) family of receptor tyrosine kinase (RTK). It is first identified as transforming gene, isolated from primary human myeloid leukemia cells. Axl gene is located in chromosome 19, at 19q13.1 , which encodes 894 amino acids with molecular weight range between 100 and 140kDa. Axl receptor is having extracellular, transmembrane and an intracellular domain. Extra cellular domain contains two immunoglobulin like (IgL) and fibronectin type-III (FN III) like domain with a single pass transmembrane domain.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
129689view00:47, 22 May 2024EweitzModified title
129211view01:33, 16 March 2024EweitzOntology Term : 'colorectal cancer' added !
129210view01:33, 16 March 2024EweitzOntology Term : 'osteosarcoma' added !
129209view01:32, 16 March 2024EweitzOntology Term : 'regulatory T cell' added !
129208view01:30, 16 March 2024EweitzFix typo
126496view21:59, 9 May 2023AlexanderPicoremoved "Other" datanode xrefs
126493view19:56, 9 May 2023Khanspersmore datanode identifiers
126492view19:43, 9 May 2023Khanspersremoved labels as datanode identifier
126491view19:27, 9 May 2023KhanspersReverted to version '23:56, 2 May 2023' by Khanspers
126490view19:26, 9 May 2023Khanspersconnected interactions
126473view23:56, 2 May 2023Khanspersremoved "activation" from legend. This should be indicated with interactions and not as a node color. Or added as a structured comment for the phosphosite.
126472view23:53, 2 May 2023Khanspersremoved unnecessary comments
126471view23:52, 2 May 2023Khanspersadded xrefs
126470view23:45, 2 May 2023Khanspersremoved colors, changed labels to label type, connected interactions
123895view11:28, 25 August 2022Finterlyfixed special shape
115887view16:19, 19 March 2021Keshav
115876view06:03, 19 March 2021Keshav
115875view05:58, 19 March 2021KeshavPathway update
111812view18:27, 8 September 2020EgonwRemoved a space in a PubMed identifier.
111809view16:01, 8 September 2020EgonwRemoved semicolons from the PubMed identifiers
111785view14:01, 7 September 2020DeSlRemoved special characters in publication list.
111784view13:52, 7 September 2020DeSlUpdated PMID ID (removed semicolon).
111783view13:51, 7 September 2020DeSlUpdated SRC protein ID
111515view05:07, 24 August 2020Rex D A Bupdate
111146view06:44, 20 July 2020Rex D A Blegend updated
111142view03:27, 19 July 2020Rex D A B
111141view03:25, 19 July 2020Rex D A BConnections
111140view13:18, 18 July 2020KeshavModified description
111138view11:14, 17 July 2020Rex D A BConnections and protein name
109999view19:17, 11 April 2020KeshavOntology Term : 'Gas6 - Axl signaling axis' added !
109998view19:11, 11 April 2020Keshavinteractions
109917view16:59, 6 April 2020KhanspersOntology Term : 'signaling pathway' added !
109422view07:26, 17 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
RPS6KA1ProteinNP_002944.2 (NCBI Protein)
ACOX1GeneProduct51 (Entrez Gene)
ACTA1GeneProduct58 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
ADAM11GeneProduct4185 (Entrez Gene)
ADGRE1GeneProductADGRE1
AHNAK2GeneProduct113146 (Entrez Gene)
AKT1GeneProductAKT1 (Other)
AKT3GeneProduct10000 (Entrez Gene)
ANGPT2GeneProduct285 (Entrez Gene)
ANXA2GeneProductANXA2
ATF2ProteinNP_001871.2 (NCBI Protein)
ATG5GeneProduct9474 (Entrez Gene)
AXIN2GeneProductAXIN2
AXLProteinNP_068713.2 (NCBI Protein)
AngiogenesisPathway
Anti-apoptotic Signaling Pathway
ApoptosisPathway
AutophagyPathway
BCL2GeneProduct596 (Entrez Gene)
BCL2L1GeneProduct596 (Entrez Gene)
BECN1GeneProduct8678 (Entrez Gene)
BIRC5GeneProductBIRC5
BMP6GeneProduct654 (Entrez Gene)
BMP7GeneProduct655 (Entrez Gene)
BMP8AGeneProduct353500 (Entrez Gene)
BMP8BGeneProduct656 (Entrez Gene)
Bcl-2GeneProductBcl-2
CALD1GeneProduct800 (Entrez Gene)
CASP1GeneProductCASP1
CASP3GeneProduct836 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CAV2GeneProduct858 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND1GeneProductCCND1
CCNE1 GeneProductCCNE1
CCR2GeneProduct729230 (Entrez Gene)
CD274GeneProduct29126 (Entrez Gene)
CD36GeneProduct948 (Entrez Gene)
CDH1GeneProductCDH1
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CHEK1Protein1111 (Entrez Gene)
CHEK1ProteinCHEK1 (NCBI Protein)
CHUKProteinNP_001269.3 (NCBI Protein)
CIP2AGeneProduct57650 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
CPT1AGeneProduct1374 (Entrez Gene)
CTLA4GeneProduct12477 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNB1GeneProductCTNNB1
CXCL16GeneProduct58191 (Entrez Gene)
CXCR6GeneProduct10663 (Entrez Gene)
CYR61 GeneProduct3491 (Entrez Gene)
Cell migrationPathway
Cell survivalPathway
DAPKGeneProduct1612 (Entrez Gene)
DKK3GeneProduct27122 (Entrez Gene)
EGFRGeneProductEGFR
EGFRGeneProductEGFR (Other)
ELMO1Protein9844 (Entrez Gene)
FASGeneProductFAS
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO1ProteinNP_002006.2 (NCBI Protein)
FOXP3GeneProduct50943 (Entrez Gene)
GAS6GeneProduct2621 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
GSK3B ProteinNP_002084.2 (NCBI Protein)
IL-18GeneProduct3606 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRS-1GeneProduct3667 (Entrez Gene)
JUNProteinNP_002219.1 (NCBI Protein)
KDRProtein3791 (Entrez Gene)
KRASGeneProductKRAS
LEF1GeneProduct51176 (Entrez Gene)
LIGHTGeneProduct8740 (Entrez Gene)
LINC00526GeneProduct147525 (Entrez Gene)
LTBGeneProduct4050 (Entrez Gene)
LYNGeneProductLYN
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MAPK9ProteinNP_002743.3 (NCBI Protein)
MCP1GeneProductMCP1
MDM2GeneProductMDM2
MDM4GeneProductMDM4
MDM4ProteinNP_002384.2 (NCBI Protein)
MERTKProtein10461 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MKI67GeneProductMKI67
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MTORProteinNP_004949.1 (NCBI Protein)
MYC GeneProduct4609 (Entrez Gene)
MYCGeneProductMYC
NFKBIAGeneProduct4790 (Entrez Gene)
NFKBIAProteinNP_065390.1 (NCBI Protein)
NLRP3GeneProduct114548 (Entrez Gene)
NRG1GeneProduct3084 (Entrez Gene)
PAK1ProteinNP_002567.3 (NCBI Protein)
PARP1GeneProduct142 (Entrez Gene)
PDK1GeneProductPDK1
PI3KProteinNP_006209.2 (NCBI Protein)
PPARGGeneProduct5468 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PTK2ProteinNP_001186578.1 (NCBI Protein)
PTPN11ProteinNP_002825.3 (NCBI Protein)
RACProteinNP_008839.2 (NCBI Protein)
RELAGeneProduct5970 (Entrez Gene)
RELAProteinNP_065390.1 (NCBI Protein)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6ProteinNP_001001.2 (NCBI Protein)
S100A10 GeneProductS100A10
SCDGeneProduct6319 (Entrez Gene)
SERPINE1GeneProductSERPINE1
SLUGGeneProductSLUG
SMAD3ProteinNP_005893.1 (NCBI Protein)
SMOGeneProduct6608 (Entrez Gene)
SNAI1GeneProduct6615 (Entrez Gene)
SNAI2GeneProduct6591 (Entrez Gene)
SNAI3GeneProduct333929 (Entrez Gene)
SNAILGeneProductSNAIL
SOCS1GeneProduct8651 (Entrez Gene)
SOCS1GeneProductSOCS1
SOCS3GeneProduct9021 (Entrez Gene)
SOCS3GeneProductSOCS3
SP1GeneProduct28423548 (Entrez Gene)
SPARCGeneProduct6678 (Entrez Gene)
SRCProteinNP_005408.1 (NCBI Protein)
STAT1ProteinNP_009330.1 (NCBI Protein)
STAT3Protein6774 (Entrez Gene)
TFGeneProductTF
TGF4GeneProduct6925 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB1I1GeneProduct7041 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TMEFF1GeneProduct8577 (Entrez Gene)
TMEM132AGeneProduct54972 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNS2ProteinNP_056134.2 (NCBI Protein)
TP53GeneProductTP53 (NCBI Protein)
TWISTGeneProduct7291 (Entrez Gene)
VAV1ProteinNP_005419.2 (NCBI Protein)
VCAM-1GeneProduct7412 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VIMGeneProduct7431 (Entrez Gene)
YESGeneProductYES
ZEB1GeneProduct6935 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4847"
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