Aerobic glycolysis - augmented (Homo sapiens)

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2HATPMetaboliteNADApplies to PKA and PKL; does not apply to PKMx 12.5O2CytosolExtracellular environmentCytosolExtracellular environmentx 12.5x 12.5x 3CytosolMitochondrionx 2.5x 2.5x 2.5StimulationCatalysisConversionBranch pathway originatingfrom the glycolysisGlycolytic metaboliteEnzyme or processMetabolite that is only in the supplementEnzyme or process that isonly in the supplementChemicals; colour codedfor better visualisationEffector of the reactionpointed atConversion of acatalysing chemicalMetabolite that is fixedin the computer modelMetabolite that is only in the article figureMetabolite that is in the supplement and article figure,but not in the modelEnzyme or process that isonly the article figureEnzyme or process that isin the supplement and articlefigure, but not in the modelATPAMPHHKGLUT_2PGMALBPGPYRGAPPGKENOTriglyceride synthesisATPGPILDHG6PSerine biosynthesisGlycogen metabolismLACPEPG6PDHPKGSYNGPHOSPentose Phosphate Pathway_3PGHGLUF6PDHAPALDPFKGLUeGAPDHADPFBPPGMTPIATPADPAMP1NADPNADHHATPADPATPADPLACeNADNADHADPPATPOXPHOSNADHMASADPPATPNADATPATPaseADPHPADPADPAKPYRF26BPATPADPCRPCRCKSERNADNADHHPHGDHGLYGHMTGRPDHATPADPGPSALTGPTSPTNADPHATPPDHASPH2OO2eO2PathwayMetaboliteEnzymeMetaboliteMetaboliteEnzymeMetaboliteEnzymeEnzyme


Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH.

This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model the corresponding supplement, and the article of Shestov et al., 2014. Note that for the purposes of this WikiPathways model, the passive transport of oxygen and lactic acid into the cell is depicted using dashed arrows, which may differ from the original computer model. A second version, only containing the content of the model itself, can be found here [1].

This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [2]

Referred article: Shestov et al., 2014

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Ontology Terms

 

Bibliography

  1. Berg JM, Tymoczko JL, Stryer L; ''Biochemistry''; https://www.ncbi.nlm.nih.gov/books/NBK22395/, 2002
  2. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC Scholia
  3. Carbonell J, Felíu JE, Marco R, Sols A; ''Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues.''; Eur J Biochem, 1973 PubMed Europe PMC Scholia
  4. Shestov AA, Liu X, Ser Z, Cluntun AA, Hung YP, Huang L, Kim D, Le A, Yellen G, Albeck JG, Locasale JW; ''Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.''; Elife, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134298view06:21, 20 July 2024EgonwAdded the reference from the description to the reference list too
134296view06:06, 20 July 2024EgonwRemoved a template comment
129607view00:46, 19 May 2024EweitzModified title
129566view15:10, 13 May 2024EweitzModified description
129565view15:09, 13 May 2024EweitzRefine legend
129564view15:08, 13 May 2024EweitzRefine legend, economize layout
129563view14:55, 13 May 2024EweitzModified title
129561view14:53, 13 May 2024EweitzRefine legend, economize layout
129408view15:57, 11 April 2024KhanspersModified description
129403view21:02, 10 April 2024KhanspersModified description
129402view20:53, 10 April 2024Khansperscompleted legend
129401view19:06, 10 April 2024Khanspersupdate legend - work in progress
129400view18:57, 10 April 2024KhanspersModified description
129399view18:53, 10 April 2024KhanspersModified description
129398view18:51, 10 April 2024Khanspersupdated legend
129397view18:50, 10 April 2024Khanspersremoved LACT and OXYT nodes (passive transport)
127024view09:56, 19 July 2023Ash iyerDatanode clickable.
127023view09:49, 19 July 2023Ash iyerDatanodes clickable.
127022view09:47, 19 July 2023Ash iyerMade datanodes clickable.
127021view09:45, 19 July 2023Ash iyerMade datanodes clickable.
127020view09:43, 19 July 2023Ash iyerMade pathway nodes clickable.
127012view09:14, 19 July 2023Ash iyerData annotation update.
127011view08:37, 19 July 2023Ash iyerOntology Term : 'cancer pathway' added !
127010view21:43, 18 July 2023Khanspersattempt at switching node fill color for edge color
125611view12:04, 4 March 2023EgonwMinor updates: fixed a HGNC identifier, removed to incorrect identifiers, and make a pathway clickable
125610view11:59, 4 March 2023EgonwRemoved duplicate reference fields
119265view07:53, 23 June 2021FinterlyAdded ISBN for book citation
117689view12:09, 22 May 2021EweitzModified title
109374view14:57, 16 March 2020L DupuisConnected line
109373view14:57, 16 March 2020L DupuisConverted interaction lines to graphical lines
107176view14:26, 17 September 2019MaintBotChEBI identifier normalization
106805view13:28, 17 September 2019MaintBotHMDB identifier normalization
105520view08:43, 8 August 2019KJanssenChanged descriptions in legend
105419view16:31, 7 August 2019DeSlRemoved licence number and last modified part.
105417view16:30, 7 August 2019DeSlRemoved reference which was not connected to anything
105416view16:28, 7 August 2019DeSlRemoved weird signs in another lit. ref
105415view16:25, 7 August 2019DeSlRemoved weird signs in lit. ref
105414view16:20, 7 August 2019DeSlConverted interactions in legend to graphical lines, to avoid unconnected lines warning
105134view11:43, 10 July 2019EgonwRemoved a few '0' identifiers.
104985view20:32, 27 June 2019KJanssenChanged colour coding and legend
104935view00:26, 26 June 2019AlexanderPicoModified title
104903view07:09, 24 June 2019KJanssenAdded PDH
104640view07:00, 7 June 2019EgonwA few more.
104636view06:02, 7 June 2019EgonwIf there is no identifier, plz leave the Xref fields empty.
104616view08:07, 4 June 2019KJanssenModified description
104614view08:05, 4 June 2019KJanssen
104612view08:02, 4 June 2019KJanssenUpdated legend
104611view07:53, 4 June 2019KJanssen
104609view07:42, 4 June 2019KJanssenUpdated legend, also some minor changes in the pathway.
104608view07:18, 4 June 2019KJanssenModified title

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
AKGeneProduct2.7.4.3 (Enzyme Nomenclature)
ALDGeneProduct226 (Entrez Gene)
ALTGeneProduct
AMPMetabolite16027 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
ASPGeneProduct
ATPMetabolite15422 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPaseGeneProduct
BPGMetaboliteHMDB0001270 (HMDB)
CKGeneProduct2.7.3.2 (Enzyme Nomenclature)
CRMetaboliteHMDB0000064 (HMDB)
DHAPMetaboliteHMDB0001473 (HMDB)
ENOGeneProduct2023 (Entrez Gene)
F26BPMetaboliteHMDB0001047 (HMDB)
F6PMetaboliteCHEBI:61527 (ChEBI)
FBPMetaboliteHMDB0001058 (HMDB)
G6PMetaboliteCHEBI:75052 (ChEBI) Glucose-6-Phosphate (2-)
G6PDHGeneProduct4057 (HGNC Accession number)
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPMetaboliteHMDB0001112 (HMDB)
GHMTGeneProduct2.1.2.1 (Enzyme Nomenclature)
GLUMetaboliteHMDB0000122 (HMDB)
GLUTGeneProduct6513 (Entrez Gene)
GLUeMetaboliteHMDB0000122 (HMDB)
GLYMetaboliteHMDB0000187 (HMDB)
GPHOSGeneProduct
GPIGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
GPSGeneProduct
GPTGeneProduct2875 (Entrez Gene)
GRPDHGeneProduct
GSYNGeneProduct
Glycogen metabolismPathwayWP500 (WikiPathways)
H2OMetaboliteCHEBI:26689 (ChEBI)
HMetaboliteCHEBI:49637 (ChEBI)
HKGeneProduct3098 (Entrez Gene)
LACMetaboliteHMDB0000190 (HMDB)
LACeMetaboliteHMDB0000190 (HMDB)
LDH GeneProduct3939 (Entrez Gene)
MALGeneProduct
MAS
NADMetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
O2MetaboliteCHEBI:26689 (ChEBI)
O2eMetaboliteCHEBI:26689 (ChEBI)
OXPHOS
PMetaboliteCHEBI:28659 (ChEBI)
PCRMetaboliteHMDB0001511 (HMDB)
PDHGeneProduct
PEPMetaboliteHMDB0000263 (HMDB)
PFKGeneProduct5213 (Entrez Gene) Type your comment here
PGK GeneProduct5230 (Entrez Gene)
PGM GeneProduct5224 (Entrez Gene)
PHGDHGeneProduct
PKGeneProduct5315 (Entrez Gene)
PYRMetaboliteHMDB0000243 (HMDB)
Pentose Phosphate PathwayPathwayWP134 (WikiPathways)
SERMetaboliteHMDB0000187 (HMDB)
SPTGeneProduct
Serine biosynthesisPathway
TPIGeneProduct7167 (Entrez Gene)
Triglyceride synthesisPathwayWP325 (WikiPathways)
_2PGMetaboliteHMDB0000362 (HMDB)
_3PGMetaboliteHMDB0000807 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4628"
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