Pilocytic astrocytoma (Homo sapiens)

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Nucleus21CytoplasmCell growth,survival,motilityCytoplasmic targetsTranscription factorsKIAA1549:BRAFfusion proteinSRGAP3:RAF1fusion proteinRAS in "on" statePlasma membraneRegular MAPK cascade pathwayRTKPTPN11ERKRAS:GTPNF1BRAFGDPMEKRAF1GRB2SOS1RASRAS in "off" state


Description

This pathway shows the relationship between BRAF signalling and the development and behavior of pilocytic astrocytoma (PA), normally induced by MAPK pathway activation.

BRAF is related in two alternative mechanisms in MAPK activation; first oncogenic fusion between SRGAP3 and RAF1 (highlighted in yellow); second a 3 basepair insertion in BRAF (KIAA1549, again in yellow).

This pathway is based on Figure 3" An overview of MAPK pathway alterations in PAs" from Jones et al.

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Quality Tags

Ontology Terms

 

Bibliography

  1. McKay MM, Morrison DK; ''Integrating signals from RTKs to ERK/MAPK.''; Oncogene, 2007 PubMed Europe PMC Scholia
  2. Jones DT, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP; ''Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.''; Oncogene, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129826view23:09, 22 May 2024EweitzPoint RTK to gene family
128531view15:25, 11 February 2024EweitzOntology Term : 'cancer' added !
128530view15:23, 11 February 2024EweitzEconomize layout, fix typos, increase font size for readability
112071view10:16, 18 September 2020DeSlConnected last unconnected interaction.
111811view17:25, 8 September 2020EgonwFixed another identifier.
111810view17:24, 8 September 2020EgonwFixed an Ensembl identifier
111781view13:27, 7 September 2020DeSlModified description
111780view13:26, 7 September 2020DeSlUpdated interations, added IDs for ERK and MEK, added mutation info from paper
111779view13:15, 7 September 2020DeSlAdded IDs for BRAF and RAF1
111778view13:06, 7 September 2020DeSlStarted updating interaction types + IDs RAS
111777view12:44, 7 September 2020DeSlRemoved last modified item.
111776view12:43, 7 September 2020DeSlUpdate RTK EC number (without space)
111775view12:42, 7 September 2020DeSlOntology Term : 'mitogen activated protein kinase signaling pathway' added !
111774view12:42, 7 September 2020DeSlOntology Term : 'pilocytic astrocytoma' added !
111773view12:41, 7 September 2020DeSlOntology Term : 'astrocytoma' added !
111772view12:41, 7 September 2020DeSlAdded ref for PW, updated description.
109364view14:09, 16 March 2020L DupuisConnected line
106707view13:13, 17 September 2019MaintBotHMDB identifier normalization
102358view19:49, 20 December 2018Fehrhartfixed some graphical issues
94224view22:42, 25 August 2017DeSlChanged RTK metabolite node to protein node, added ID for this node.
74520view21:34, 28 April 2014KhanspersModified title
69013view17:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
67597view11:31, 26 June 2013DdiglesOntology Term : 'glioma pathway' added !
59199view19:14, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
54370view15:01, 28 November 2012MaintBotremoved mim-gap end type
53138view02:00, 30 October 2012MaintBotModified categories
49791view10:47, 26 July 2012DeviModified description
49790view06:50, 26 July 2012DeviPilocytic astrocytoma
49771view19:24, 25 July 2012MaintBotconnected nodes to database object
49739view10:32, 25 July 2012DeviNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BRAFGeneProductENSG00000157764 (Ensembl)
ERKGeneProductIPR008350 (InterPro)
GDPMetaboliteHMDB0000960 (HMDB)
GRB2GeneProductENSG00000177885 (Ensembl)
MEKGeneProduct2.7.12.2 (Enzyme Nomenclature)
NF1GeneProductENSG00000196712 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RAS:GTPProteinIPR020849 (InterPro)
RASProteinPF00071 (Pfam)
RTKGeneProductWP5471 (WikiPathways) RTKs have to be activated first
Regular MAPK cascade pathwayPathwayWP422 (WikiPathways)
SOS1GeneProductENSG00000115904 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2253"
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