CAMKK2 pathway (Homo sapiens)

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LabelCAMKK2 pathwayVCAM1MAP1LC3ACALM1DRP1MAFCa2+STIM1NFATC2HMOX1FIS1IFI44L41434420, 44GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins15ERMAPRPTOR3NEDD4LCaulerpin36ABCA1HK2MTORS244829CYB5R3CAMK118S100A8ACACA39S79HK2ARHGEF7S516 38EPORFOXO3AS321S31840CCNE1PFKFB2TMEM176BIsorhamnetin31Adropin17CCL5Hydrogen sulphide19TRPV4EP300S1834 30KDRSFI1WDR35Ramipril14SMC139NRF2MAP1LC3BCCND1NOS3 8S1177SLCO3A1MAPK14 Y12216TSPAN33NLRP1WFS110MAP1LC3AMAPK132MX2Homocysteine sulfinic acid16FAM132aCD28KEAP1MID1Apigenin5IL15RPS6KB1HMBSEstrogen9CD28CAMK425PRELA33VCAM1OASLCTSEMetabolitesSPINT1NOS142SREBF1CDH1GIT138SQSTM135MAP1LC3BRASGRP1Withdrawal of essential amino acids13PPAP2AEugenol12IRGCGlyceollin7RPS6PAK1 24CREB130HFEQuercetin1WFS1PCK2Hypoxia28CDC25AOxytocin23SELLTSPAN8CHRM320TREM3EIF4EBP1S65T37T466SLC2A4ATP1B2PLAC8ICAM122GATMGDH1 26Poly unsaturated fatty acids21TNFCAMKK215, 34TBXTLaminar shear stress30AQP1ACACARAC124IRS-1S639S6367, 40CXCL11GCKSPIRE1PARP1Pulsed electric field2CCR9HDCA425EPORBupivacaine33FAM20CHMOX1Betulinic acid8INN41CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 37T642 ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC16SIRT1 27AKTT308S47311RPS6KB1T389AutophagyAnoikisAnaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA2T17215ULK1317S757S555 ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK3TSC232T1462 6PRKCAT639 4NRF2NUCYNUCYCytoplasmMetabolitesActivationmRNA


Description

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well-characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522). The creation of this pathway is described in Najar et al.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
134958view09:42, 30 July 2024EgonwAdded datanode types based on the xref datasource
134666view14:27, 25 July 2024Ash iyerupdate metabolites annotation and added grahical elements.
134665view14:11, 25 July 2024Ash iyerchanging datanodes to graphical elements.
134664view14:06, 25 July 2024Ash iyeradded missing annotation on datanodes.
134659view10:40, 25 July 2024Ash iyeradd missing annotation for datanodes
134658view10:20, 25 July 2024Ash iyerModified description
134646view08:55, 24 July 2024EgonwRemoved labels that were listed as identifier without datasource
126535view09:44, 29 May 2023EgonwTyped datanodes
124683view07:26, 24 November 2022Rex D A B
121708view04:43, 26 February 2022EweitzUse gene symbol
117669view11:58, 22 May 2021EweitzModified title
113833view08:50, 30 November 2020Fehrhartconnected some of the unconnected lines
113771view18:21, 19 November 2020KhanspersModified description
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProduct
ACACAGeneProduct
ACACAProteinNP_942131.1 (NCBI Protein)
AHSPGeneProductAHSP
AKTProteinNP_001014431.1 (NCBI Protein)
AQP1GeneProduct
ARHGEF7GeneProduct8874 (Entrez Gene)
ASNSGeneProductASNS
ATP10DGeneProduct
ATP1B2GeneProduct
AdropinProteinIPR034461 (InterPro)
ApigeninMetaboliteCHEBI:18388 (ChEBI)
Betulinic acidMetaboliteCHEBI:3087 (ChEBI)
BupivacaineMetaboliteCHEBI:31322 (ChEBI)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CAR1GeneProduct
CCL5GeneProduct
CCND1GeneProduct
CCND2GeneProduct
CCNE1GeneProduct
CCR9GeneProduct
CD28GeneProduct
CDC25AGeneProduct
CDH1GeneProduct
CHRM3GeneProduct1131 (Entrez Gene)
CPOXGeneProduct
CREB1GeneProduct1385 (Entrez Gene)
CRTC2GeneProduct
CTSEGeneProduct
CXCL11GeneProduct
CYB5R3GeneProduct
Ca2+Metabolite
CaulerpinMetaboliteCHEBI:80923 (ChEBI)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProduct
ERMAPGeneProductERMAP
EstrogenGeneProduct
EugenolMetaboliteCHEBI:4917 (ChEBI)
FAM132aGeneProduct
FAM20CGeneProduct
FASNGeneProductFASN
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GALNT9GeneProductGALNT9
GATMGeneProductGATM
GCKGeneProduct
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteCHEBI:16470 (ChEBI)
HDCA4GeneProduct9759 (Entrez Gene)
HFEGeneProduct
HIF1AGeneProduct
HK1GeneProduct
HK2GeneProduct
HMBSGeneProduct
HMOX1GeneProduct3162 (Entrez Gene)
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideGeneProduct
HypoxiaPathway
ICAM1GeneProduct3383 (Entrez Gene)
IFI44LGeneProductIFI44L
IL15GeneProduct
INNGeneProduct
IRGCGeneProduct
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
KDRGeneProduct
KEAP1GeneProduct
KLF1GeneProductKLF1
Laminar shear stressPathwayLaminar shear stress (Other)
MAFGeneProduct4094 (Entrez Gene)
MAMDC2GeneProduct
MAP1LC3AGeneProduct
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3BGeneProduct
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MID1GeneProduct
MS4A3GeneProduct
MT1GeneProduct
MTORGeneProduct2475 (Entrez Gene)
MX2GeneProduct
MetabolitesGeneProduct
NEDD4LGeneProductNEDD4L
NFATC2GeneProduct4773 (Entrez Gene)
NLRP1GeneProduct
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct
NRF2GeneProduct4780 (Entrez Gene)
OASLGeneProduct
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (NCBI Protein)
PARP1GeneProduct
PCK2GeneProduct
PFKFB2GeneProduct
PFKFB2GeneProductPFKFB2
PFKFB3GeneProduct
PLAC8GeneProduct
PPAP2AGeneProduct
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
Pulsed electric fieldGeneProduct
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RASGRP1GeneProduct
RELAGeneProduct5970 (Entrez Gene)
RHAGGeneProduct
RHDGeneProduct
RPS6GeneProduct
RPS6KB1GeneProduct
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
S100A8GeneProduct
SELLGeneProduct
SFI1GeneProduct
SIRT1 GeneProduct23411 (Entrez Gene)
SLC25A21GeneProduct
SLC2A1GeneProduct
SLC2A4GeneProduct
SLC38A5GeneProduct
SLCO3A1GeneProduct
SMC1GeneProduct8243 (Entrez Gene)
SPINT1GeneProduct
SPIRE1GeneProduct
SQSTM1GeneProduct8878 (Entrez Gene)
SREBF1GeneProduct
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TBXTGeneProduct
TMEM176BGeneProduct
TNFGeneProduct
TREM3GeneProduct
TRPV4GeneProduct
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
TSPAN33GeneProduct
TSPAN8GeneProduct
TheasinensinsMetabolite
ULK1GeneProduct
VCAM1GeneProduct7412 (Entrez Gene)
WDR35GeneProduct
WFS1GeneProduct
WFS1GeneProduct7466 (Entrez Gene)
Withdrawal of essential amino acidsGeneProduct

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4874"
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