CAMKK2 pathway (Homo sapiens)

From WikiPathways

Revision as of 14:27, 25 July 2024 by Ash iyer (Talk | contribs)
Jump to: navigation, search
Laminar shear stressPulsed electric fieldWithdrawal of essential amino acids.14313LabelCAMKK2 pathwayVCAM1MAP1LC3ACALM1DRP1MAFCa2+STIM1NFATC2HMOX1FIS1IFI44L27321010, 16GATMASNSKLF1GALNT9FASNPFKFB2Theasinensins8ERMAPRPTOR39NEDD4LCaulerpin22ABCA1HK2MTORS244817CYB5R3CAMK134S100A8ACACAS7923HK2ARHGEF7S516 35EPORFOXO3A11S318S321CCNE1PFKFB2TMEM176BIsorhamnetin5Adropin36CCL5Hydrogen sulphide42TRPV4EP300S1834 3KDRSFI1WDR35Ramipril38SMC123NRF2MAP1LC3BCCND1NOS3 S117728SLCO3A1MAPK14 Y12241TSPAN33NLRP1WFS119MAP1LC3AMAPK118MX2Homocysteine sulfinic acid41C1QTNF12CD28KEAP1MID1Apigenin1IL15RPS6KB1HMBSEstrogen29CD28CAMK4P25RELA9VCAM1OASLCTSEMetabolitesSPINT1NOS144SREBF1CDH1GIT135SQSTM121MAP1LC3BRASGRP1PPAP2AEugenol4IRGCGlyceollin30RPS6PAK1 7CREB13HFEQuercetin24WFS1PCK2Hypoxia43CDC25AOxytocin15SELLTSPAN8CHRM316TREM3EIF4EBP1T466T37S65SLC2A4ATP1B2PLAC8ICAM133GATMGDH1 37Poly unsaturated fatty acids40TNFCAMKK28, 12TBXTAQP1ACACARAC17IRS-111, 30S636S639CXCL11GCKSPIRE1PARP1CCR9HDCA425EPORBupivacaine9FAM20CHMOX1Betulinic acid28INN27CCND2HK1SLC2A1CAR1SLC25A21RHDMAMDC2MT1TBC1D4 T642 26ATP10DCRTC2MS4A3PFKFB3SLC38A5AHSPCPOXRHAGFatty acid biosysthesisTranslocationPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionInduced catalysisLEGENDProteinNucleusCytoplasmCYNUProtein-protein dissociationInhibitionSmall moleculePlasma membranePMNucleusSmall moleculeCREB1TSC16SIRT1 31AKTT3082S473RPS6KB1T389AutophagyAnoikisAnaerobic metabolismCytokineCellcycleHypoxiaCalcium channel transporterApoptosisGlyconeogensis Signal transductionTransportHeme biosynthesisHIF1AMembraneChemokineHK1Erythrocyte developmentPRKAA2T1728ULK1S757S555 317ApoptosisCell proliferation and migrationUbiquitinationDissociationMAPK318TSC2T1462 6PRKCA20T639 NRF2NUCYNUCYCytoplasmMetabolitesActivationmRNA


Description

CaMKK2 is a 66–68-kDa serine kinase, consists of unique N- and C-terminal domains and a central Ser/Thr-directed kinase domain that is followed by a regulatory domain composed of overlapping autoinhibitory and CaM-binding regions (PMID:9335539). CAMKK2 is activated once calmodulin (CALM1) binds with CAAMKK2. The most well-characterized substrates of CaMKK2 are CaMKI, CaMKIV and AMPKα. CaMKK2 phosphorylates CaMKIV, CaMKI and AMPKα on activation loop Thr residues (Thr-200, Thr-177 and Thr-172, respectively), which increases their kinase activities (PMID:9822657). CaMKK2 is present in many areas of the brain, including the olfactory bulb, hippocampus, dentate gyrus, amygdala, hypothalamus, and cerebellum (PMID:9822657, 12654522). The creation of this pathway is described in Najar et al.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Tong X, Smith KA, Pelling JC; ''Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes.''; Mol Carcinog, 2012 PubMed Europe PMC Scholia
  2. Cheng PY, Lee YM, Law KK, Lin CW, Yen MH; ''The involvement of AMP-activated protein kinases in the anti-inflammatory effect of nicotine in vivo and in vitro.''; Biochem Pharmacol, 2007 PubMed Europe PMC Scholia
  3. Takai J, Santu A, Zheng H, Koh SD, Ohta M, Filimban LM, Lemaître V, Teraoka R, Jo H, Miura H; ''Laminar shear stress upregulates endothelial Ca²�-activated K� channels KCa2.3 and KCa3.1 via a Ca²�/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.''; Am J Physiol Heart Circ Physiol, 2013 PubMed Europe PMC Scholia
  4. Jo HK, Kim GW, Jeong KJ, Kim DY, Chung SH; ''Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway.''; Biol Pharm Bull, 2014 PubMed Europe PMC Scholia
  5. Dong GZ, Lee JH, Ki SH, Yang JH, Cho IJ, Kang SH, Zhao RJ, Kim SC, Kim YW; ''AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction.''; Eur J Pharmacol, 2014 PubMed Europe PMC Scholia
  6. Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG; ''The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.''; EMBO J, 2011 PubMed Europe PMC Scholia
  7. Kwon HB, Castillo PE; ''Long-term potentiation selectively expressed by NMDA receptors at hippocampal mossy fiber synapses.''; Neuron, 2008 PubMed Europe PMC Scholia
  8. Qiu J, Maekawa K, Kitamura Y, Miyata Y, Tanaka K, Tanaka T, Soga M, Tsuda T, Matsui T; ''Stimulation of glucose uptake by theasinensins through the AMP-activatedprotein kinase pathway in rat skeletal muscle cells.''; Biochem Pharmacol, 2014 PubMed Europe PMC Scholia
  9. Huang L, Kondo F, Gosho M, Feng GG, Harato M, Xia ZY, Ishikawa N, Fujiwara Y, Okada S; ''Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells.''; PLoS One, 2014 PubMed Europe PMC Scholia
  10. Marcelo KL, Means AR, York B; ''The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.''; Trends Endocrinol Metab, 2016 PubMed Europe PMC Scholia
  11. Gocher AM, Azabdaftari G, Euscher LM, Dai S, Karacosta LG, Franke TF, Edelman AM; ''Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells.''; J Biol Chem, 2017 PubMed Europe PMC Scholia
  12. Abbott MJ, Edelman AM, Turcotte LP; ''CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.''; Am J Physiol Regul Integr Comp Physiol, 2009 PubMed Europe PMC Scholia
  13. Ghislat G, Patron M, Rizzuto R, Knecht E; ''Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β).''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  14. Morotomi-Yano K, Akiyama H, Yano K; ''Nanosecond pulsed electric fields activate AMP-activated protein kinase: implications for calcium-mediated activation of cellular signaling.''; Biochem Biophys Res Commun, 2012 PubMed Europe PMC Scholia
  15. Lee ES, Uhm KO, Lee YM, Kwon J, Park SH, Soo KH; ''Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium-CaMKK-AMPK pathway.''; Regul Pept, 2008 PubMed Europe PMC Scholia
  16. Wang N, Yao M, Xu J, Quan Y, Zhang K, Yang R, Gao WQ; ''Autocrine Activation of CHRM3 Promotes Prostate Cancer Growth and Castration Resistance via CaM/CaMKK-Mediated Phosphorylation of Akt.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia
  17. Lv C, Wu C, Zhou YH, Shao Y, Wang G, Wang QY; ''Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway.''; Int J Endocrinol, 2014 PubMed Europe PMC Scholia
  18. Schmitt JM, Guire ES, Saneyoshi T, Soderling TR; ''Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation.''; J Neurosci, 2005 PubMed Europe PMC Scholia
  19. Wang Y, Zhang Y, Peng H, Rui J, Zhang Z, Wang S, Li Z; ''WSF-P-1, a novel AMPK activator, promotes adiponectin multimerization in 3T3-L1 adipocytes.''; Biosci Biotechnol Biochem, 2017 PubMed Europe PMC Scholia
  20. Kim N, Lee JO, Lee HJ, Lee YW, Kim HI, Kim SJ, Park SH, Lee CS, Ryoo SW, Hwang GS, Kim HS; ''AMPK, a metabolic sensor, is involved in isoeugenol-induced glucose uptake in muscle cells.''; J Endocrinol, 2016 PubMed Europe PMC Scholia
  21. Takasawa K, Takasawa A, Osanai M, Aoyama T, Ono Y, Kono T, Hirohashi Y, Murata M, Sawada N; ''Claudin-18 coupled with EGFR/ERK signaling contributes to the malignant potentials of bile duct cancer.''; Cancer Lett, 2017 PubMed Europe PMC Scholia
  22. Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, Kong Z, Dai X, Xu B; ''Metabolic reprogramming and AMPKα1 pathway activation by caulerpin in colorectal cancer cells.''; Int J Oncol, 2017 PubMed Europe PMC Scholia
  23. Vara-Ciruelos D, Dandapani M, Gray A, Egbani EO, Evans AM, Hardie DG; ''Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.''; Mol Cancer Res, 2018 PubMed Europe PMC Scholia
  24. Dhanya R, Arya AD, Nisha P, Jayamurthy P; ''Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line.''; Front Pharmacol, 2017 PubMed Europe PMC Scholia
  25. Hirata M, Endo K, Katsumata K, Ichikawa F, Kubodera N, Fukagawa M; ''A comparison between 1,25-dihydroxy-22-oxavitamin D(3) and 1,25-dihydroxyvitamin D(3) regarding suppression of parathyroid hormone secretion and calcaemic action.''; Nephrol Dial Transplant, 2002 PubMed Europe PMC Scholia
  26. White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C, Frigo DE; ''GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.''; Endocr Relat Cancer, 2018 PubMed Europe PMC Scholia
  27. Yang H, Zhao P, Tian S; ''Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway.''; J Diabetes Res, 2016 PubMed Europe PMC Scholia
  28. Jin SW, Choi CY, Hwang YP, Kim HG, Kim SJ, Chung YC, Lee KJ, Jeong TC, Jeong HG; ''Betulinic Acid Increases eNOS Phosphorylation and NO Synthesis via the Calcium-Signaling Pathway.''; J Agric Food Chem, 2016 PubMed Europe PMC Scholia
  29. Yang S, Wang J; ''Estrogen Activates AMP-Activated Protein Kinase in Human Endothelial Cells via ERβ/Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase β Pathway.''; Cell Biochem Biophys, 2015 PubMed Europe PMC Scholia
  30. Yoon EK, Jeong YT, Li X, Song-Cui, Park DC, Kim YH, Kim YD, Chang HW, Lee SH, Hwang SL; ''Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes.''; J Nutr Biochem, 2013 PubMed Europe PMC Scholia
  31. Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T; ''Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.''; Nature, 2010 PubMed Europe PMC Scholia
  32. Huang Q, Cao H, Zhan L, Sun X, Wang G, Li J, Guo X, Ren T, Wang Z, Lyu Y, Liu B, An J, Xing J; ''Mitochondrial fission forms a positive feedback loop with cytosolic calcium signaling pathway to promote autophagy in hepatocellular carcinoma cells.''; Cancer Lett, 2017 PubMed Europe PMC Scholia
  33. Martinelli R, Gegg M, Longbottom R, Adamson P, Turowski P, Greenwood J; ''ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration.''; Mol Biol Cell, 2009 PubMed Europe PMC Scholia
  34. Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, Selbert MA, Edelman AM, Fremeau RT, Means AR; ''Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.''; J Biol Chem, 1998 PubMed Europe PMC Scholia
  35. Saneyoshi T, Wayman G, Fortin D, Davare M, Hoshi N, Nozaki N, Natsume T, Soderling TR; ''Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex.''; Neuron, 2008 PubMed Europe PMC Scholia
  36. Yang F, Zhou L, Qian X, Wang D, He WJ, Tang ZW, Yin J, Huang QY; ''Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats.''; Front Mol Neurosci, 2017 PubMed Europe PMC Scholia
  37. Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S; ''The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.''; Mol Cell, 2018 PubMed Europe PMC Scholia
  38. Tian S, Ge X, Wu K, Yang H, Liu Y; ''Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation.''; J Pharmacol Exp Ther, 2014 PubMed Europe PMC Scholia
  39. Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM; ''Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.''; Autophagy, 2015 PubMed Europe PMC Scholia
  40. Kang S, Huang J, Lee BK, Jung YS, Im E, Koh JM, Im DS; ''Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120).''; Biochim Biophys Acta Mol Cell Biol Lipids, 2018 PubMed Europe PMC Scholia
  41. Kim JH, Lee JO, Lee SK, Moon JW, You GY, Kim SJ, Park SH, Park JM, Lim SY, Suh PG, Uhm KO, Song MS, Kim HS; ''The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells.''; J Biol Chem, 2011 PubMed Europe PMC Scholia
  42. Chen X, Zhao X, Lan F, Zhou T, Cai H, Sun H, Kong W; ''Hydrogen Sulphide Treatment Increases Insulin Sensitivity and Improves Oxidant Metabolism through the CaMKKbeta-AMPK Pathway in PA-Induced IR C2C12 Cells.''; Sci Rep, 2017 PubMed Europe PMC Scholia
  43. Sallé-Lefort S, Miard S, Nolin MA, Boivin L, Paré MÈ, Debigaré R, Picard F; ''Hypoxia upregulates Malat1 expression through a CaMKK/AMPK/HIF-1α axis.''; Int J Oncol, 2016 PubMed Europe PMC Scholia
  44. Harten SK, Shukla D, Barod R, Hergovich A, Balda MS, Matter K, Esteban MA, Maxwell PH; ''Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.''; Mol Biol Cell, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134958view09:42, 30 July 2024EgonwAdded datanode types based on the xref datasource
134666view14:27, 25 July 2024Ash iyerupdate metabolites annotation and added grahical elements.
134665view14:11, 25 July 2024Ash iyerchanging datanodes to graphical elements.
134664view14:06, 25 July 2024Ash iyeradded missing annotation on datanodes.
134659view10:40, 25 July 2024Ash iyeradd missing annotation for datanodes
134658view10:20, 25 July 2024Ash iyerModified description
134646view08:55, 24 July 2024EgonwRemoved labels that were listed as identifier without datasource
126535view09:44, 29 May 2023EgonwTyped datanodes
124683view07:26, 24 November 2022Rex D A B
121708view04:43, 26 February 2022EweitzUse gene symbol
117669view11:58, 22 May 2021EweitzModified title
113833view08:50, 30 November 2020Fehrhartconnected some of the unconnected lines
113771view18:21, 19 November 2020KhanspersModified description
112884view18:20, 14 October 2020EgonwReplaced gene symbols by Entrez Gene identifiers
112274view00:43, 9 October 2020Rex D A Bconnections and gene name
112262view12:10, 8 October 2020KeshavModified description
111803view15:17, 7 September 2020DeSlRemoved special characters for TNF- node (assuming this is TNF-alpha).
111802view15:15, 7 September 2020DeSladded ID for Adropin (changed from Metabolite to Protein, since it's a peptide hormone).
111801view15:11, 7 September 2020DeSladded ID for Apigenin
111800view15:10, 7 September 2020DeSladded ID for Betulinic acid
111799view15:09, 7 September 2020DeSladded ID for bupivacine (assumed this should be bupivacaine, as wikipedia suggests)
111798view15:07, 7 September 2020DeSladded ID for cauleprin (assumed this should be caulerpin, as reference suggests)
111796view14:48, 7 September 2020DeSladded ID for eugenol
111795view14:44, 7 September 2020DeSladded ID for Glyceollin
111794view14:43, 7 September 2020DeSladded ID for Homocysteine sulfinic acid
111793view14:38, 7 September 2020DeSladded ID for Isorhamnetin
111792view14:36, 7 September 2020DeSladded ID for oxytocin
111791view14:28, 7 September 2020DeSladded ID for quericin (assumed this should be quercetin, as reference suggests)
111790view14:26, 7 September 2020DeSladded ID for ramipril
111789view14:24, 7 September 2020DeSlremoved name as ID for Theasinensins
110018view19:19, 12 April 2020Keshavconnections
110016view19:13, 12 April 2020KeshavInteractions
109756view18:30, 30 March 2020KeshavOntology Term : 'cancer' added !
109755view18:29, 30 March 2020KeshavOntology Term : 'calcium/calcium-mediated signaling pathway' added !
109750view17:53, 30 March 2020KeshavTitle
109749view17:49, 30 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABCA1GeneProductABCA1 (HGNC)
ACACAGeneProductACACA (HGNC)
ACACAProteinNP_942131.1 (NCBI Protein)
AHSPGeneProductAHSP (HGNC)
AKTProteinNP_001014431.1 (NCBI Protein)
AQP1GeneProductAQP1 (HGNC)
ARHGEF7GeneProduct8874 (Entrez Gene)
ASNSGeneProductASNS (HGNC)
ATP10DGeneProductATP10D (HGNC)
ATP1B2GeneProductATP1B2 (HGNC)
AdropinProtein375704 (Entrez Gene)
ApigeninMetaboliteCHEBI:18388 (ChEBI)
Betulinic acidMetaboliteCHEBI:3087 (ChEBI)
BupivacaineMetaboliteCHEBI:31322 (ChEBI)
C1QTNF12GeneProduct388581 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
CAMK1GeneProduct8536 (Entrez Gene)
CAMK4GeneProduct814 (Entrez Gene)
CAMKK2GeneProduct10645 (Entrez Gene)
CAR1GeneProductCAR1 (HGNC)
CCL5GeneProduct6352 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CCR9GeneProductCCR9 (HGNC)
CD28GeneProduct940 (Entrez Gene)
CD28GeneProductCD28 (HGNC)
CDC25AGeneProductCDC25A (HGNC)
CDH1GeneProductCDH1 (HGNC)
CHRM3GeneProduct1131 (Entrez Gene)
CPOXGeneProductCPOX (HGNC)
CREB1GeneProduct1385 (Entrez Gene)
CRTC2GeneProductCRTC2 (HGNC)
CTSEGeneProduct1510 (Entrez Gene)
CXCL11GeneProductCXCL11 (HGNC)
CYB5R3GeneProductCYB5R3 (HGNC)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CaulerpinMetaboliteCHEBI:80923 (ChEBI)
DRP1GeneProduct10059 (Entrez Gene)
EIF4EBP1ProteinNP_004086.1 (NCBI Protein)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProduct2057 (Entrez Gene)
ERMAPGeneProductERMAP (HGNC)
EstrogenMetaboliteCHEBI:50114 (ChEBI)
EugenolMetaboliteCHEBI:4917 (ChEBI)
FAM20CGeneProduct56975 (Entrez Gene)
FASNGeneProductFASN (HGNC)
FIS1GeneProduct51024 (Entrez Gene)
FOXO3AProteinNP_001446.1 (NCBI Protein)
GALNT9GeneProductGALNT9 (HGNC)
GATMGeneProductGATM (HGNC)
GCKGeneProductGCK (HGNC)
GDH1 GeneProduct854557 (Entrez Gene)
GIT1GeneProduct28964 (Entrez Gene)
GlyceollinMetaboliteCHEBI:16470 (ChEBI)
HDCA4GeneProduct9759 (Entrez Gene)
HFEGeneProductHFE (HGNC)
HIF1AGeneProductHIF1A (HGNC)
HK1GeneProductHK1 (HGNC)
HK2GeneProductHK2 (HGNC)
HMBSGeneProductHMBS (HGNC)
HMOX1GeneProduct3162 (Entrez Gene)
Homocysteine sulfinic acidMetaboliteCHEBI:137439 (ChEBI)
Hydrogen sulphideCHEBI:16136 (ChEBI)
HypoxiaPathway
ICAM1GeneProduct3383 (Entrez Gene)
IFI44LGeneProductIFI44L (HGNC)
IL15GeneProduct3600 (Entrez Gene)
INNGeneProductINN (HGNC)
IRGCGeneProduct56269 (Entrez Gene)
IRS-1ProteinNP_005535.1 (NCBI Protein)
IsorhamnetinMetaboliteCHEBI:6052 (ChEBI)
KDRGeneProductKDR (HGNC)
KEAP1GeneProductKEAP1 (HGNC)
KLF1GeneProductKLF1 (HGNC)
MAFGeneProduct4094 (Entrez Gene)
MAMDC2GeneProductMAMDC2 (HGNC)
MAP1LC3AGeneProduct84557 (Entrez Gene)
MAP1LC3AGeneProductMAP1LC3A (HGNC)
MAP1LC3BGeneProductMAP1LC3B (HGNC)
MAPK14 ProteinNP_001306.1 (NCBI Protein)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3 GeneProduct5595 (Entrez Gene)
MID1GeneProduct4281 (Entrez Gene)
MS4A3GeneProductMS4A3 (HGNC)
MT1GeneProduct17748 (Entrez Gene)
MTORGeneProduct2475 (Entrez Gene)
MX2GeneProduct4600 (Entrez Gene)
MetabolitesGeneProduct
NEDD4LGeneProductNEDD4L (HGNC)
NFATC2GeneProduct4773 (Entrez Gene)
NLRP1GeneProductNLRP1 (HGNC)
NOS1GeneProduct4842 (Entrez Gene)
NOS3 ProteinNP_000594.2 (NCBI Protein)
NRF2GeneProduct4780 (Entrez Gene)
NRF2GeneProductNRF2 (HGNC)
OASLGeneProduct8638 (Entrez Gene)
OxytocinMetaboliteCHEBI:7872 (ChEBI)
PAK1 GeneProduct5058 (Entrez Gene)
PARP1GeneProduct142 (Entrez Gene)
PCK2GeneProductPCK2 (HGNC)
PFKFB2GeneProductPFKFB2 (HGNC)
PFKFB3GeneProductPFKFB3 (HGNC)
PLAC8GeneProduct51316 (Entrez Gene)
PPAP2AGeneProductPPAP2A (HGNC)
PRKAA2GeneProductNP_006243.2 (NCBI Protein)
PRKCAProteinNP_002728.1 (NCBI Protein)
Poly unsaturated fatty acidsGeneProduct
ProteinProtein5894 (Entrez Gene)
QuercetinMetaboliteCHEBI:16243 (ChEBI)
RAC1GeneProduct5879 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RHAGGeneProductRHAG (HGNC)
RHDGeneProductRHD (HGNC)
RPS6KB1GeneProductRPS6KB1 (HGNC)
RPS6GeneProductRPS6 (HGNC)
RPTORGeneProduct57521 (Entrez Gene)
RamiprilMetaboliteCHEBI:8774 (ChEBI)
S100A8GeneProduct6279 (Entrez Gene)
SELLGeneProduct6402 (Entrez Gene)
SFI1GeneProduct9814 (Entrez Gene)
SIRT1 GeneProduct23411 (Entrez Gene)
SLC25A21GeneProduct89874 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SLC2A4GeneProductSLC2A4 (HGNC)
SLC38A5GeneProduct92745 (Entrez Gene)
SLCO3A1GeneProductSLCO3A1 (HGNC)
SMC1GeneProduct8243 (Entrez Gene)
SPINT1GeneProductSPINT1 (HGNC)
SPIRE1GeneProduct56907 (Entrez Gene)
SQSTM1GeneProduct8878 (Entrez Gene)
SREBF1GeneProductSREBF1 (HGNC)
STIM1GeneProduct6786 (Entrez Gene)
TBC1D4 ProteinNP_001273587.1 (NCBI Protein)
TBXTGeneProduct6862 (Entrez Gene)
TMEM176BGeneProductTMEM176B (HGNC)
TNFGeneProduct7124 (Entrez Gene)
TREM3GeneProductTREM3 (HGNC)
TRPV4GeneProduct59341 (Entrez Gene)
TSC1GeneProduct7248 (Entrez Gene)
TSC2ProteinNP_000539.2 (NCBI Protein)
TSPAN33GeneProductTSPAN33 (HGNC)
TSPAN8GeneProductTSPAN8 (HGNC)
Theasinensins390965 (Chemspider)
ULK1GeneProductULK1 (HGNC)
VCAM1GeneProduct7412 (Entrez Gene)
WDR35GeneProduct57539 (Entrez Gene)
WFS1GeneProduct7466 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4874"
Personal tools