Serotonin HTR1 group and FOS pathway (Homo sapiens)

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Description

This pathway depicts the downstream signaling of serotonin via the receptors 1 group, resulting in the production of FOS via ELK-SRF and CREB1. This pathway also shows the downstream signaling of serotonin via receptor 2A, resulting in the activation of STAT3.

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Revision	Action	Time	User	Comment
136011	view	14:34, 8 December 2024	Eweitz	Fix graphics discrepancy between PathVisio and Kaavio / Pvjs
136010	view	13:18, 8 December 2024	Eweitz	Clear cache to update board dimensions
136009	view	13:16, 8 December 2024	Eweitz	Economize layout
136008	view	03:50, 8 December 2024	Eweitz	Refine legend
136007	view	03:47, 8 December 2024	Eweitz	Increase font size, for readability
136006	view	03:39, 8 December 2024	Eweitz	Refine legend
136005	view	03:33, 8 December 2024	Eweitz	Economize layout
136004	view	03:32, 8 December 2024	Eweitz	Economize layout
125764	view	14:31, 9 March 2023	DeSl	Added rhea ID and ref. for PI3K interaction
125763	view	14:27, 9 March 2023	DeSl	Fixed PI3K enzyme conversion
125656	view	15:59, 6 March 2023	DeSl	Integrated description from WP733
125655	view	15:58, 6 March 2023	DeSl	Integrated WP733
125651	view	15:51, 6 March 2023	DeSl	Added two annotations
125650	view	15:47, 6 March 2023	DeSl	Converted (in)direct regulation to MIM-stimulation
125649	view	15:43, 6 March 2023	DeSl	Vretical layout, converted arrow to MIM-conversion
125648	view	15:41, 6 March 2023	DeSl	Changed layout
125647	view	15:40, 6 March 2023	DeSl	Converted some arrows to specific MIM-types
125646	view	15:35, 6 March 2023	DeSl	Updating to current color scheme
125633	view	02:01, 6 March 2023	AlexanderPico	Modified description
125272	view	15:34, 31 January 2023	Egonw	Fixed two more references
125271	view	15:22, 31 January 2023	Egonw	Fixed a reference
120570	view	01:00, 17 December 2021	Khanspers	updated lit refs
120569	view	00:58, 17 December 2021	Khanspers	updated lit refs
120568	view	00:45, 17 December 2021	Khanspers	fixed literature references to remove weird characters
117823	view	15:06, 22 May 2021	Eweitz	Modified title
106177	view	12:07, 16 August 2019	MaintBot	HMDB identifier normalization
102357	view	19:43, 20 December 2018	Fehrhart	fixed unconnected lines
102125	view	17:03, 1 December 2018	Egonw	Removed whitespace in PubMed identifiers.
74511	view	05:59, 27 April 2014	Egonw	Last batch of PubMed ID fixes.
74501	view	17:12, 26 April 2014	Egonw	More PubMed ID fixes.
74499	view	16:58, 26 April 2014	Egonw	Fixed PubMed IDs.
73767	view	00:49, 22 February 2014	MaintBot	updating schema
49735	view	09:04, 25 July 2012	Andra	RDF Tidy
49638	view	10:31, 23 July 2012	Andra	RDF Tidy
49633	view	09:57, 23 July 2012	Andra	RDF Tidy
49625	view	09:24, 23 July 2012	Andra	RDF Tidy
49624	view	09:22, 23 July 2012	Andra	RDF Tidy
49621	view	08:51, 23 July 2012	Andra	RDF Tidy
49580	view	07:14, 21 July 2012	Andra	RDF Tidy
49556	view	19:33, 20 July 2012	Andra	RDF tidy
49540	view	09:59, 20 July 2012	Andra	Corrected references
49539	view	09:48, 20 July 2012	Andra	Corrected a erroneous pubmed reference
49534	view	09:06, 20 July 2012	Andra	Corrected a pubmed error
46093	view	03:28, 15 December 2011	AlexanderPico	converted more hugo to hgnc
45025	view	18:43, 6 October 2011	Thomas	Ontology Term : 'serotonin signaling pathway' added !
41105	view	23:22, 1 March 2011	MaintBot	Removed redundant pathway information and comments
39767	view	07:54, 17 January 2011	AlexanderPico
34469	view	18:32, 10 December 2009	MaintBot	Automatic update of empty xrefs
33424	view	14:53, 30 November 2009	MaintBot	Removed group label
33185	view	17:56, 5 November 2009	Khanspers	Modified categories

External references

DataNodes

View all...

Name	Type	Database reference	Comment
1,2-Diacetin	Metabolite	102-62-5 (CAS)	diacylglycerol
1,4,5-Insp3	Metabolite	85166-31-0 (CAS)
BRAF	GeneProduct	673 (Entrez Gene)	v-raf murine sarcoma viral oncogene homolog B1
CALCIUM	Metabolite	7440-70-2 (CAS)
CREB1	GeneProduct	1385 (Entrez Gene)	cAMP response element-binding protein 1
ELK1	GeneProduct	2002 (Entrez Gene)	ELK1, member of ETS oncogene family
ELK4	GeneProduct	2005 (Entrez Gene)	ETS domain-containing protein Elk-4 (SRF accessory protein 1)
FOS	GeneProduct	2353 (Entrez Gene)	proto-oncogene protein c-fos
GNAI1	Protein	2770 (Entrez Gene)
GNAI2	Protein	2771 (Entrez Gene)
GNAI3	Protein	2773 (Entrez Gene)
GNAO1	Protein	2775 (Entrez Gene)
GNAQ	GeneProduct	2776 (Entrez Gene)	guanine nucleotide binding protein, alpha q polypeptide
Gb/g	Complex
HTR1A	Protein	3350 (Entrez Gene)
HTR1B	Protein	3351 (Entrez Gene)
HTR1D	Protein	3352 (Entrez Gene)
HTR1E	Protein	3354 (Entrez Gene)
HTR1F	Protein	3355 (Entrez Gene)
HTR2A	GeneProduct	3356 (Entrez Gene)	5-hydroxytryptamine (serotonin) receptor 2A
ITPR1	GeneProduct	3708 (Entrez Gene)	inositol 1,4,5-triphosphate receptor 1
JAK2	GeneProduct	3717 (Entrez Gene)	Janus kinase 2
MAP2K1	GeneProduct	5604 (Entrez Gene)	mitogen activated protein kinase kinase 1
MAP2K2	GeneProduct	5605 (Entrez Gene)	mitogen activated protein kinase kinase 2
MAP2K3	GeneProduct	5606 (Entrez Gene)	mitogen activated protein kinase kinase 3
MAP2K6	GeneProduct	5608 (Entrez Gene)	mitogen activated protein kinase kinase 6
MAP3K1	GeneProduct	4214 (Entrez Gene)	mitogen activated protein kinase kinase kinase 1
MAPK14	GeneProduct	1432 (Entrez Gene)	mitogen activated protein kinase 14
MAPK1	GeneProduct	MAPK1 (HGNC)	mitogen activated protein kinase 1
MAPK3	GeneProduct	5595 (Entrez Gene)	mitogen activated protein kinase 3
MAPKAPK2	GeneProduct	9261 (Entrez Gene)	mitogen activated protein kinase 3
MAPKAPK3	GeneProduct	7867 (Entrez Gene)	mitogen-activated protein kinase-activated protein kinase 3
PDPK1	GeneProduct	5170 (Entrez Gene)	3-phosphoinositide dependent protein kinase-1
PI3K	GeneProduct	5290 (Entrez Gene)	phosphatidylinositol 3-kinase
PKC	GeneProduct	50818 (Entrez Gene)	protein kinase C
PLC	GeneProduct	3.1.4.11 (Enzyme Nomenclature)	phospholipase C
PtdIns2P	Metabolite	CHEBI:58456 (ChEBI)	phosphatidylinositol 4,5-diphosphate
PtdIns3P	Metabolite	57836 (ChEBI)	phosphatidylinositol 3,4,5-triphosphate
RAP1A	GeneProduct	5906 (Entrez Gene)	RAS-related protein-1a
RASGRF1	GeneProduct	5923 (Entrez Gene)	RAS protein-specific guanine nucleotide-releasing factor 1
RASGRP1	GeneProduct	10125 (Entrez Gene)	RAS guanyl releasing protein 1
RHOA	GeneProduct	387 (Entrez Gene)	ras homolog gene family, member A
RPS6K	GeneProduct		Functional Class RPS6K (ribosomal protein S6 kinase)
RPS6KA5	GeneProduct	9252 (Entrez Gene)	ribosomal protein S6 kinase, polypeptide 5
Ras	GeneProduct		RAS oncogene homolog
SRF	GeneProduct	6722 (Entrez Gene)	serum response factor
STAT3	GeneProduct	6774 (Entrez Gene)	signal transducer and activator of transcription
Serotonin	Metabolite	HMDB0000259 (HMDB)

Annotated Interactions

Source	Target	Type	Database reference	Comment
PtdIns2P	PtdIns3P	mim-conversion	21293 (Rhea)

Serotonin HTR1 group and FOS pathway (Homo sapiens)

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