NO/cGMP/PKG mediated neuroprotection (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Endothelial cellNucleusSmall solublesNeuronMitochondrionMicrogliaCalmodulinCa2+CALM1NR2 SubunitsNR1 Interacting ProteinsNMDAR: Ligand ComplexNMDA ReceptorNR1 SubunitCAMK IIGRIN2DACTN2GRIN2BCAMK2GAKAP9CAMK2BNEFLGRIN2ACAMK2ACAMK2DGRIN2CGRIN1Mg2+DLG4ACTN2DLG4NR2 Interacting ProteinsNatriuretric PeptidesANPBNPMitochondrialPermeabilityTransitionPoreTSPOCyclophilin DsGCGUCY1B2GUCY1A2GUCY1A3GUCY1B3NF-kBNFKB1NFKB3A SubunitsCNG Cation ChannelsB SubunitsCNGB1CNGA3CNGA2CNGA1CNGB3CNGA4Cell depolarizationNADPXIAPPDE3O2GTPL-ArginineIL-1BeNOSNPR1K+L-CitrullineCASP9BCL2Caspase cascadenNOSNOCa2+ApoptosisL-GlutamatePDE2NADPHCytochrome CcGMPTNF-aPKG2TBHNFKBIAIFN-GammaAMPCREB1Ca2+LPSiNOScAMPO2L-ArginineNADPHTBHNADPL-CitrullineNOCalmodulinCa2+CALM1O2L-ArginineNADPHTBHNADPL-CitrullineNONOSmall solublesK+Ca2+BADSmall SolublesK+Ca2+Small solublesK+Ca2+Mitochondrial depolarizationCytochrome CName: NO/cGMP/PKG mediated neuroprotectionOrganism: Homo sapiens


Description

NO/cGMP/PKG Neuroprotection. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Image:NeedsRef.pngAdd references
Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
137675view20:07, 6 March 2025KhanspersModified description
136680view14:01, 19 February 2025EweitzStandardize case
136679view13:59, 19 February 2025EweitzEconomize layout
136678view13:54, 19 February 2025EweitzOntology Term : 'endothelial cell' added !
136677view13:54, 19 February 2025EweitzOntology Term : 'microglial cell' added !
125786view10:03, 10 March 2023DeSlConverted PW node to current color scheme, added link for caspase cascade
123318view07:41, 16 July 2022EgonwTyped a datanode
117805view14:30, 22 May 2021EweitzModified title
110707view14:19, 28 May 2020LaurentAdded missing DataNode types - and one missing ID
107157view14:24, 17 September 2019MaintBotChEBI identifier normalization
106656view21:17, 12 September 2019KhanspersModified description
105657view05:15, 10 August 2019KhanspersModified description
96448view09:26, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96378view06:46, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
92677view11:02, 28 June 2017SauerThorbenOntology Term : 'signaling pathway involving second messengers' added !
92676view11:01, 28 June 2017SauerThorbenOntology Term : 'signaling pathway' added !
92675view11:01, 28 June 2017SauerThorbenOntology Term : 'neuron' added !
92674view11:01, 28 June 2017SauerThorbenOntology Term : 'neural cell' added !
92673view11:01, 28 June 2017SauerThorbenOntology Term : 'dementia' added !
92672view09:59, 28 June 2017SauerThorbenModified title
92671view09:57, 28 June 2017SauerThorbenNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ACTN2GeneProductENSG00000077522 (Ensembl)
AKAP9GeneProductENSG00000127914 (Ensembl)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANPGeneProductENSG00000175206 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BNP GeneProductENSG00000120937 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CAMK2BGeneProductENSG00000058404 (Ensembl)
CAMK2DGeneProductENSG00000145349 (Ensembl)
CAMK2GGeneProductENSG00000148660 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CNGA1GeneProductENSG00000198515 (Ensembl)
CNGA2GeneProductENSG00000183862 (Ensembl)
CNGA3GeneProductENSG00000144191 (Ensembl)
CNGA4GeneProductENSG00000132259 (Ensembl)
CNGB1GeneProductENSG00000070729 (Ensembl)
CNGB3GeneProductENSG00000170289 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Caspase cascadePathwaySee https://www.abeomics.com/caspase-cascade as example for PW model
Cyclophilin DGeneProductENSG00000171497 (Ensembl)
Cytochrome CGeneProductENSG00000172115 (Ensembl)
DLG4GeneProductENSG00000132535 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2D GeneProductENSG00000105464 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
IFN-GammaProteinENSG00000111537 (Ensembl)
IL-1BProteinENSG00000125538 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
L-ArginineMetaboliteCHEBI:16467 (ChEBI)
L-CitrullineMetaboliteCHEBI:16349 (ChEBI)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
LPSMetaboliteCHEBI:89981 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEFLGeneProductENSG00000277586 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB3GeneProductENSG00000173039 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
O2MetaboliteCHEBI:29372 (ChEBI)
PDE2GeneProductENSG00000186642 (Ensembl)
PDE3GeneProductENSG00000172572 (Ensembl)
PKG2GeneProductENSG00000138669 (Ensembl)
TBHMetaboliteCHEBI:64090 (ChEBI)
TNF-a ProteinENSG00000232810 (Ensembl)
TSPOGeneProductENSG00000100300 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
eNOSGeneProductENSG00000164867 (Ensembl)
iNOSGeneProductENSG00000007171 (Ensembl)
nNOSGeneProductENSG00000089250 (Ensembl)

Annotated Interactions

No annotated interactions

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