NO/cGMP/PKG mediated neuroprotection (Homo sapiens)

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Description

NO/cGMP/PKG mediated Neuroprotection. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP4008).

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
140399view11:15, 17 August 2025EgonwMore unicode
140189view04:36, 6 August 2025EgonwMore unicode
140084view20:23, 24 July 2025EgonwMore unicode
139815view08:49, 7 July 2025DdiglesDeleted hidden old description
137675view20:07, 6 March 2025KhanspersModified description
136680view14:01, 19 February 2025EweitzStandardize case
136679view13:59, 19 February 2025EweitzEconomize layout
136678view13:54, 19 February 2025EweitzOntology Term : 'endothelial cell' added !
136677view13:54, 19 February 2025EweitzOntology Term : 'microglial cell' added !
125786view10:03, 10 March 2023DeSlConverted PW node to current color scheme, added link for caspase cascade
123318view07:41, 16 July 2022EgonwTyped a datanode
117805view14:30, 22 May 2021EweitzModified title
110707view14:19, 28 May 2020LaurentAdded missing DataNode types - and one missing ID
107157view14:24, 17 September 2019MaintBotChEBI identifier normalization
106656view21:17, 12 September 2019KhanspersModified description
105657view05:15, 10 August 2019KhanspersModified description
96448view09:26, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96378view06:46, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
92677view11:02, 28 June 2017SauerThorbenOntology Term : 'signaling pathway involving second messengers' added !
92676view11:01, 28 June 2017SauerThorbenOntology Term : 'signaling pathway' added !
92675view11:01, 28 June 2017SauerThorbenOntology Term : 'neuron' added !
92674view11:01, 28 June 2017SauerThorbenOntology Term : 'neural cell' added !
92673view11:01, 28 June 2017SauerThorbenOntology Term : 'dementia' added !
92672view09:59, 28 June 2017SauerThorbenModified title
92671view09:57, 28 June 2017SauerThorbenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTN2GeneProductENSG00000077522 (Ensembl)
AKAP9GeneProductENSG00000127914 (Ensembl)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANPGeneProductENSG00000175206 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BNP GeneProductENSG00000120937 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CAMK2BGeneProductENSG00000058404 (Ensembl)
CAMK2DGeneProductENSG00000145349 (Ensembl)
CAMK2GGeneProductENSG00000148660 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CNGA1GeneProductENSG00000198515 (Ensembl)
CNGA2GeneProductENSG00000183862 (Ensembl)
CNGA3GeneProductENSG00000144191 (Ensembl)
CNGA4GeneProductENSG00000132259 (Ensembl)
CNGB1GeneProductENSG00000070729 (Ensembl)
CNGB3GeneProductENSG00000170289 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Caspase cascadePathwaySee https://www.abeomics.com/caspase-cascade as example for PW model
Ca²⁺MetaboliteCHEBI:29108 (ChEBI)
Cyclophilin DGeneProductENSG00000171497 (Ensembl)
Cytochrome CGeneProductENSG00000172115 (Ensembl)
DLG4GeneProductENSG00000132535 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
IFN-GammaProteinENSG00000111537 (Ensembl)
IL-1BProteinENSG00000125538 (Ensembl)
K⁺MetaboliteCHEBI:29103 (ChEBI)
L-ArginineMetaboliteCHEBI:16467 (ChEBI)
L-CitrullineMetaboliteCHEBI:16349 (ChEBI)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
LPSMetaboliteCHEBI:89981 (ChEBI)
Mg²⁺MetaboliteCHEBI:18420 (ChEBI)
NADPMetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEFLGeneProductENSG00000277586 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB3GeneProductENSG00000173039 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
O₂MetaboliteCHEBI:29372 (ChEBI)
PDE2GeneProductENSG00000186642 (Ensembl)
PDE3GeneProductENSG00000172572 (Ensembl)
PKG2GeneProductENSG00000138669 (Ensembl)
TBHMetaboliteCHEBI:64090 (ChEBI)
TNF-aProteinENSG00000232810 (Ensembl)
TSPOGeneProductENSG00000100300 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
eNOSGeneProductENSG00000164867 (Ensembl)
iNOSGeneProductENSG00000007171 (Ensembl)
nNOSGeneProductENSG00000089250 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4008"
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