Folate metabolism (Homo sapiens)

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41272018311613, 16291282414, 22719, 211728BInfluence on expressionTBTGeneric enzymeBBNegative effectBReactionBindingIEBNucleotide biosynthesisSynthesis of cholineMain functionsBBBTransformationBFormation of methionineTFormation of HemeCompetitionBBBBBBBBTTBBInterconversionConversionTransportMETABOLITEBTINORGANIC IONBINTRACELULARUnspecified interactionBBTBBTCNTUnspecified effectPositive effectBBPLASMA15-HETESODCopperMethionine2-Ketobutyric acidL-Glutamic acidManganeseGlycineSELWGPX 6Glycined6 desaturasePGG3MTHFRThromboxane B2XDHCobalamin15-HETEFMN1PGG2Pyrodoxal-5'-phosphateLeukotriene D4ALA (n-3)PGISPGE2SELKPyrodoxal-5'-phosphateDHA (n-3)PNPOF2-IsoprostaneLeukotriene B4PGD2LOX5ZincPGH2GPX 25,10-METHYL-THFNiacin5-HPETEEthanolamineLeukotriene D4NADPHMethionine sulfoxideTryptophanMethylmalonic acid METHa-tocopherolLipoxin B4CBSPGI2FOLIC ACIDEndoperoxidaseGPX 1C22:5 (n-6)FOLIC ACIDAA (n-6)ThioredoxinPGFSLA (n-6)AA (n-6)PGF2aa TocopherolCholineTRXR 2LA (n-6)BTromboxane A2EPA (n-3)PGF2aGSHRAscorbic acidVitamin B12Lipoxin A4SeleniumLeukotriene A4Lipoic acidKMOd5 desaturase1-MethylnicotinamidePGI2RiboflavinS-Adenosylmethionine PGDSAdipic acid T1-methylnicotinamideGPX 3 d4 desaturaseTranscobalaminL-Glutamic acidTRXR 3Vitamin B12Thromboxane A2DHA (n-3)GlutathioneAdipic acidCatalaseCopperNADPHCalciumEthanolaminePGE3TTH2OLeukotrieneE4CysteineLeukotrieneE4CalciumUric acidALA (n-3)XanthineLeukotriene C4Uric acidHomocysteineAscorbic acidS-Adenosylhomocysteine NADPFADiPF2-alphaCobalaminROSHypoxanthineS-Adenosylhomocysteine Leukotriene F4IronLipoxin A45,10-METHYL-THFEPA (n-3)TRXR 1BetaineS-AdenosylmethionineHypoxanthineTHASSeleniumSerinePTGESPGH3PGE2CarnitineCOX2Leukotriene B4SerineZincL-MethionineCystathioneSELRMethylmalonic acidGPX 4H2O2CNLeukotriene C4PGD2BGlutathione disulfideHemeC22:5 (n-6)CysteineIronCOX1NADP2-Ketobutyric acidO2HomocysteineGlutathioneIENicotinamide10215255, 26239


Description

The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.

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History

View all...
CompareRevisionActionTimeUserComment
134132view12:12, 30 June 2024EgonwMarked the "From intracellular part to the plasma" interactions as mim-translocation
121696view03:31, 26 February 2022EweitzFix gene symbol
120904view14:08, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
120275view13:13, 23 November 2021EgonwRemoved duplicate reference data
118404view14:12, 27 May 2021Marvin M2empty refs removed, 1 pubmed Id added
117725view12:34, 22 May 2021EweitzModified title
107123view14:20, 17 September 2019MaintBotChEBI identifier normalization
106422view22:01, 28 August 2019KhanspersModified description
106179view12:07, 16 August 2019MaintBotHMDB identifier normalization
105599view04:49, 10 August 2019KhanspersModified description
105139view15:21, 10 July 2019DeSlUpdated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.
104839view14:22, 20 June 2019Fehrhartfixed an interaction NADPH - anchor
104837view14:16, 20 June 2019Fehrhart
101939view06:14, 19 November 2018EgonwReplaced Wikipedia with Wikidata identifiers.
98245view14:17, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
97550view14:45, 24 May 2018Youssefwalid
97549view14:44, 24 May 2018YoussefwalidNOS ID mapping to Uniprot
96337view15:34, 8 March 2018Mkutmonremove old WP category
96279view08:20, 5 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
95971view09:23, 11 February 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
95130view16:06, 16 November 2017Fehrhartconnecting unconnected connections
95129view16:03, 16 November 2017Fehrhartconnecting unconnected lines
93690view15:08, 9 August 2017DeSlModified description
85063view11:25, 10 April 2016EgonwReplaced a Wikipedia ID with a ChEBI ID.
82704view08:49, 23 October 2015EgonwoxLDL has a separate identifier.
79883view12:32, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 12831960)
79877view11:39, 23 April 2015Mkutmonuse labels and graphical lines in the legend
74202view07:11, 5 April 2014EgonwReplaced "Other" data sources with nothing and with Wikipedia.
74096view13:37, 29 March 2014EgonwFibrin from PubChem is a metabolite.
72364view09:11, 13 November 2013EgonwWhere WP identifiers were given as comment and Wikipedia already listed as DataSource, I fixed the identifier.
71710view20:02, 17 October 2013MaintBotremoved data source from nodes without identifier
70465view11:12, 5 August 2013EgonwLinked to the WP page.
70111view19:07, 12 July 2013MaintBotupdated to 2013 schema
68034view10:41, 29 June 2013EgonwMore char encoding fixes in references.
68033view10:26, 29 June 2013EgonwFixed char encoding issues in references.
68032view10:04, 29 June 2013EgonwFixed EC number data source.
68030view09:57, 29 June 2013EgonwFixed an char encoding issue in a reference.
60226view20:06, 14 March 2013EgonwRemoved more escape codes in PubChem-substance identifier, and replaced one with a PubChem-compound ID.
60225view20:03, 14 March 2013EgonwRemoved escape code.
57622view20:18, 30 January 2013EgonwFibrin PubChem references are PubChem-compound.
56291view16:08, 5 January 2013EgonwFixed fibrin node data type from protein to metabolite.
54695view12:27, 7 December 2012Andra
54694view12:17, 7 December 2012AndraSpecify description
49543view10:10, 20 July 2012AndraWp tidy
49538view09:38, 20 July 2012AndraCorrected error in identifier
48247view06:19, 17 May 2012MaintBotUpdating PubChem xrefs
45271view18:50, 7 October 2011AlexanderPicoOntology Term : 'pathway of folate cycle/metabolism' added !
41127view23:37, 1 March 2011MaintBotRemoved redundant pathway information and comments
39753view06:58, 17 January 2011AlexanderPicomore specific title
36515view12:55, 29 March 2010Damarizohdg

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-MethylnicotinamideMetaboliteHMDB00699 (HMDB)
1-methylnicotinamideMetaboliteHMDB00699 (HMDB)
15-HETEMetaboliteHMDB02218 (HMDB)
2-Ketobutyric acidMetaboliteHMDB00005 (HMDB)
5,10-METHYL-THFMetaboliteHMDB01396 (HMDB)
5-HPETEMetaboliteHMDB01193 (HMDB)
AA (n-6)MetaboliteHMDB01043 (HMDB)
ALA (n-3)MetaboliteHMDB01388 (HMDB)
Adipic acid MetaboliteHMDB00448 (HMDB)
Adipic acidMetaboliteHMDB00448 (HMDB)
Ascorbic acidMetaboliteHMDB00044 (HMDB)
BUnknown
BetaineMetaboliteHMDB00043 (HMDB)
C22:5 (n-6)MetaboliteHMDB01976 (HMDB)
CBSProtein875 (Entrez Gene)
CNUnknown
COX1Protein4512 (Entrez Gene)
COX2Protein4513 (Entrez Gene)
CalciumMetaboliteHMDB00464 (HMDB)
CarnitineMetaboliteHMDB00062 (HMDB)
CatalaseProtein847 (Entrez Gene)
CholineMetaboliteHMDB00097 (HMDB)
CobalaminMetaboliteHMDB02174 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathioneMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
DHA (n-3)MetaboliteHMDB02183 (HMDB)
EPA (n-3)MetaboliteHMDB01999 (HMDB)
EndoperoxidaseProtein
EthanolamineMetaboliteHMDB00149 (HMDB)
F2-IsoprostaneMetaboliteHMDB04659 (HMDB)
FADMetabolite703 (PubChem)
FMN1Metabolite342184 (Entrez Gene)
FOLIC ACIDMetaboliteHMDB00121 (HMDB)
GPX 1Protein2876 (Entrez Gene)
GPX 2Protein2877 (Entrez Gene)
GPX 3 Protein2878 (Entrez Gene)
GPX 4Protein2879 (Entrez Gene)
GPX 6Protein257202 (Entrez Gene)
GSHRProteinENSG00000104687 (Ensembl Human) Type your comment here
Glutathione disulfideMetabolite65359 (PubChem) Type your comment here
GlutathioneMetaboliteHMDB00125 (HMDB)
GlycineMetaboliteHMDB00123 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetabolite
HomocysteineMetaboliteHMDB00742 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IEUnknown
IronMetaboliteHMDB00692 (HMDB)
KMOProtein8564 (Entrez Gene)
L-Glutamic acidMetaboliteHMDB00148 (HMDB)
L-MethionineMetaboliteHMDB00696 (HMDB)
LA (n-6)MetaboliteHMDB00673 (HMDB)
LOX5Protein240 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene F4Metabolite
LeukotrieneE4MetaboliteHMDB02200 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
METHProtein4548 (Entrez Gene)
MTHFRProtein4524 (Entrez Gene)
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
Methylmalonic acid MetaboliteHMDB00202 (HMDB)
Methylmalonic acidMetaboliteHMDB00202 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
NADPMetaboliteHMDB00217 (HMDB)
NiacinMetaboliteHMDB01406 (HMDB)
NicotinamideMetabolite7847104 (PubChem)
O2MetaboliteHMDB01377 (HMDB)
PGD2MetaboliteHMDB01403 (HMDB)
PGDSProtein5730 (Entrez Gene)
PGE2Metabolite
PGE3MetaboliteHMDB02664 (HMDB)
PGF2aMetaboliteHMDB01139 (HMDB)
PGFSProteinEC 1.1.1.188
PGG2MetaboliteHMDB03235 (HMDB)
PGG3Metabolite
PGH2MetaboliteHMDB01381 (HMDB)
PGH3Metabolite
PGI2Metabolite
PGI2MetaboliteHMDB01335 (HMDB)
PGISProtein5740 (Entrez Gene)
PNPOProtein55163 (Entrez Gene)
PTGESProtein9536 (Entrez Gene)
Pyrodoxal-5'-phosphateMetaboliteHMDB01491 (HMDB)
ROSMetabolitehttp://en.wikipedia.org/wiki/Reactive_oxygen_species
RiboflavinMetaboliteHMDB00244 (HMDB) Type your comment here
S-Adenosylhomocysteine MetaboliteHMDB00939 (HMDB)
S-Adenosylmethionine MetaboliteHMDB01185 (HMDB)
S-AdenosylmethionineMetaboliteHMDB01185 (HMDB)
SELKProtein58515 (Entrez Gene)
SELRProtein51734 (Entrez Gene)
SELWProtein6415 (Entrez Gene)
SODProtein6647 (Entrez Gene)
SeleniumMetaboliteHMDB01349 (HMDB)
SerineMetaboliteHMDB00187 (HMDB)
TUnknown
THASProtein6916 (GenBank)
TRXR 1Protein7296 (Entrez Gene)
TRXR 2Protein10587 (Entrez Gene)
TRXR 3Protein114112 (Entrez Gene)
TTUnknown
ThioredoxinMetabolite7295 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
TranscobalaminProtein6947 (Entrez Gene)
Tromboxane A2MetaboliteHMDB01452 (HMDB)
TryptophanMetaboliteHMDB00929 (HMDB)
Uric acidMetaboliteHMDB00289 (HMDB)
Vitamin B12MetaboliteHMDB00607 (HMDB)
XDHProtein7498 (Entrez Gene)
XanthineMetaboliteHMDB00292 (HMDB)
ZincMetaboliteHMDB01303 (HMDB)
a TocopherolMetaboliteHMDB01893 (HMDB)
a-tocopherolMetaboliteHMDB01893 (HMDB)
d4 desaturaseProtein
d5 desaturaseProtein3992 (GenBank)
d6 desaturaseProtein9415 (Entrez Gene)
iPF2-alphaMetaboliteHMDB04659 (HMDB)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP176"
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