Aflatoxin B1 metabolism (Homo sapiens)

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1-4, 6-95, 105, 10nonenzymaticDNA adductsnonenzymatic(pH-dependent)Aflatoxin B1 C6-monoaldehydeAflatoxin Q1GSTM1Aflatoxin M1CYP1A2Aflatoxin B1 C8-monoaldehydeAflatoxin B1 C6-monoalcoholAflatoxin B1 C8-monoalcoholAflatoxin B1 dialdehydeAflatoxin M1 epoxideCYP2A13CYP1A2Aflatoxin B1 exo-8,9-epoxide-GSHCYP1A2AKR7A3Aflatoxin B1-6,8-dialcoholAflatoxin B1 exo-8,9-epoxideAflatoxin-endo-B1-8,9-epoxideaflatoxin B1CYP2A13AKR7A2Aflatoxin B1 8,9-dihydrodiolEPHX1GSTT1CYP3A4CYP3A4


Description

Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia
  2. Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
  3. Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
  4. Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
  5. Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
  6. Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
  7. Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
  8. He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
  9. Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  10. Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134403view20:24, 21 July 2024EweitzRefine node margin, alignment
134402view20:21, 21 July 2024EweitzIncrease font size, for better readability
124934view13:57, 1 January 2023EgonwOntology Term : 'xenobiotic metabolic pathway' added !
106828view13:30, 17 September 2019MaintBotHMDB identifier normalization
105874view04:49, 16 August 2019KhanspersModified description
105435view04:35, 8 August 2019KhanspersModified description
102199view07:25, 9 December 2018EgonwMmm... only the ENSG00000277656 link works.
102198view06:58, 9 December 2018EgonwReplaced an outdated Ensembl identifiers with the new one.
93244view11:16, 8 August 2017DeSlOntology Term : 'cancer' added !
93243view11:11, 8 August 2017DeSlChanged ID of Aflatoxin B1 exo-8,9-epoxide-GSH to more stereo scpecifi one; checked all other nodes missing IDs, found 2.
70509view11:59, 9 August 2013Mkutmonfixed unconnected line
67032view09:56, 26 June 2013Christine ChichesterOntology Term : 'aflatoxin metabolic pathway' added !
63149view20:16, 8 May 2013MaintBotUpdating GPML version
59135view22:37, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48240view06:05, 17 May 2012MaintBotUpdating PubChem xrefs
48215view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
44823view15:42, 5 October 2011MartijnVanIerselOntology Term : 'cellular detoxification pathway' added !
41090view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35014view08:24, 11 February 2010ThomasModified description
35013view08:23, 11 February 2010ThomasModified description
33414view14:50, 30 November 2009MaintBotRemoved group label
30253view04:37, 25 July 2009AlexanderPicoModified categories
29946view17:55, 14 June 2009Pieter GiesbertzExpanded pathway
29865view13:10, 8 June 2009Pieter GiesbertzAdded literature reference
29864view13:07, 8 June 2009Pieter GiesbertzAdded literature reference
29545view11:45, 14 May 2009Pieter GiesbertzAdded literature references
29338view14:36, 24 April 2009Pieter GiesbertzAdded compound identifiers
29286view07:57, 22 April 2009Pieter GiesbertzSpecify description
29267view10:50, 21 April 2009Pieter GiesbertzSpecify description
29260view14:25, 20 April 2009Pieter GiesbertzSpecify description
29259view13:43, 20 April 2009Pieter GiesbertzSpecify description
29258view13:20, 20 April 2009Pieter GiesbertzSpecify description
29257view13:19, 20 April 2009Pieter GiesbertzSpecify description
29256view12:30, 20 April 2009Pieter GiesbertzPeriodical save, work in progress
29254view09:37, 20 April 2009Pieter GiesbertzSpecify description
29253view09:29, 20 April 2009Pieter GiesbertzNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKR7A2GeneProductENSG00000053371 (Ensembl Human)
AKR7A3GeneProductENSG00000162482 (Ensembl Human)
Aflatoxin B1 8,9-dihydrodiolMetabolite3035008 (PubChem)
Aflatoxin B1 C6-monoalcoholMetabolite
Aflatoxin B1 C6-monoaldehydeMetabolite
Aflatoxin B1 C8-monoalcoholMetabolite
Aflatoxin B1 C8-monoaldehydeMetabolite
Aflatoxin B1 dialdehydeMetabolite
Aflatoxin B1 exo-8,9-epoxide-GSHMetabolite5460816 (PubChem)
Aflatoxin B1 exo-8,9-epoxideMetabolite104756 (PubChem)
Aflatoxin B1-6,8-dialcoholMetabolite
Aflatoxin M1 epoxideMetabolite
Aflatoxin M1Metabolite15558498 (PubChem)
Aflatoxin Q1Metabolite104757 (PubChem)
Aflatoxin-endo-B1-8,9-epoxideMetabolite
CYP1A2GeneProductENSG00000140505 (Ensembl Human)
CYP2A13GeneProductENSG00000197838 (Ensembl Human)
CYP3A4GeneProductENSG00000160868 (Ensembl Human)
EPHX1GeneProductENSG00000143819 (Ensembl Human)
GSTM1GeneProductENSG00000134184 (Ensembl Human)
GSTT1GeneProductENSG00000184674 (Ensembl Human)
aflatoxin B1MetaboliteHMDB06552 (HMDB)

Annotated Interactions

No annotated interactions

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