DNA replication (Caenorhabditis elegans)

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CTPCdc6Pre-replicative complexADPOrc23. DNA replication initiationDegraded by proteasome in cytosolRNA primer-DNA primer:origin duplex:PCNAp70Mcm6Mcm10ATPdUTPRFC37p49dGTPOrc3aRFC36Phosphorylated Orc1ATPADPUbiquitin4. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primer:RFC140UTPDegraded by proteasome in cytosolOrc5PCNA homotrimerMcm 4,6,7 trimer forms and associatesMcm5Mcm7Orc2RNA primer-DNA primerMcm4p58DNA polymerase alpha: primase: origin complexPhosphorylation of Mcm 2-7 complexATPPre-replicative complexMcm4ATPDNA PolymeraseUbiquitinated Orc1Mcm3Cdc6Orc4RFC Heteropentamer:RNA primer-DNA primerRNA primer-DNA primerOrc complexUbiquitinOrc2RNA PrimerRFC38Mcm2p180DNA polymerase alpha: primase: origin complexdATPOriginGemininOrc5Mcm2dCTPOrc ComplexOrc3Orc5Orc complexOrc3Orc41. Assembly of the pre-replicative complexOrc2Mcm7Cdc6Cdt1Orc3Cdt1GTPProcessive complexOrc complexCdt1RFC40Cdt1Cdc6Mcm5Cdt1Mcm6Primase5. Leading/lagging strand synthesisPhosphorylated Cdc6Orc complexwith the replication fork2. Activation of the pre-replicative complexUbiquitinated Cdc6Orc1Mcm3ORC3LCDT1pri-2RPA1RPA2ubq-2orc-2Y39A1A.12ubq-1ASKORC6LF08B4.5GMNNCDC7RPA4ARPAORC4LF10C2.4div-1ORC5LPCNAPOLD3mcm-6rfc-3Y47D3A.28pri-1F34D10.2mcm-2POLD4rfc-1rfc-2F33H2.5RPA3CDC46POLD2Y47D3A.29RFC4mcm-3CDK2mcm-7cdc-6mcm-4


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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