Target of rapamycin signaling (Homo sapiens)
From WikiPathways
Description
TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response.
TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling
Quality Tags
Ontology Terms
Bibliography
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- Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed Europe PMC Scholia
- Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed Europe PMC Scholia
- Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed Europe PMC Scholia
- Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
- Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed Europe PMC Scholia
- Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U; ''mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.''; Cell Rep, 2014 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | ENSG00000142208 (Ensembl Human) | |
AKT1S1 | GeneProduct | ENSG00000204673 (Ensembl Human) | |
CDC42 | GeneProduct | ENSG00000070831 (Ensembl Human) | |
DDIT4 | GeneProduct | ENSG00000168209 (Ensembl Human) | |
DDIT4L | GeneProduct | ENSG00000145358 (Ensembl Human) | |
EIF4EBP1 | GeneProduct | ENSG00000187840 (Ensembl Human) | |
FKBP1A | GeneProduct | ENSG00000088832 (Ensembl Human) | |
MAPKAP1 | GeneProduct | ENSG00000119487 (Ensembl Human) | |
MLST8 | GeneProduct | ENSG00000167965 (Ensembl Human) | |
MTOR | GeneProduct | ENSG00000198793 (Ensembl Human) | |
PRKAA1 | GeneProduct | ENSG00000132356 (Ensembl Human) | |
PRKAA2 | GeneProduct | ENSG00000162409 (Ensembl Human) | |
PRKAB1 | GeneProduct | ENSG00000111725 (Ensembl Human) | |
PRKAB2 | GeneProduct | ENSG00000131791 (Ensembl Human) | |
PRKAG1 | GeneProduct | ENSG00000181929 (Ensembl Human) | |
PRKAG2 | GeneProduct | ENSG00000106617 (Ensembl Human) | |
PRKAG3 | GeneProduct | ENSG00000115592 (Ensembl Human) | |
PRKCA | GeneProduct | ENSG00000154229 (Ensembl Human) | |
PRR5 | GeneProduct | ENSG00000186654 (Ensembl Human) | |
PRR5L | GeneProduct | ENSG00000135362 (Ensembl Human) | |
RAC1 | GeneProduct | ENSG00000136238 (Ensembl Human) | |
RHEB | GeneProduct | ENSG00000106615 (Ensembl Human) | |
RICTOR | GeneProduct | ENSG00000164327 (Ensembl Human) | |
RPS6KB1 | GeneProduct | ENSG00000108443 (Ensembl Human) | |
RPTOR | GeneProduct | ENSG00000141564 (Ensembl Human) | |
RRAGA | GeneProduct | ENSG00000155876 (Ensembl Human) | |
RRAGB | GeneProduct | ENSG00000083750 (Ensembl Human) | |
RRAGC | GeneProduct | ENSG00000116954 (Ensembl Human) | |
RRAGD | GeneProduct | ENSG00000025039 (Ensembl Human) | |
Rapamycin | Metabolite | 7847818 (PubChem) | |
TSC1 | GeneProduct | ENSG00000165699 (Ensembl Human) | |
TSC2 | GeneProduct | ENSG00000103197 (Ensembl Human) | |
ULK1 | GeneProduct | ENSG00000177169 (Ensembl Human) | |
ULK2 | GeneProduct | ENSG00000083290 (Ensembl Human) | |
ULK3 | GeneProduct | ENSG00000140474 (Ensembl Human) |
Annotated Interactions
No annotated interactions