DNA replication (Caenorhabditis elegans)

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GTPCdt12. Activation of the pre-replicative complexp49Orc5Pre-replicative complexRNA primer-DNA primerPrimasep180Mcm7Cdt1ADPdATPRFC38p58dUTPRFC Heteropentamer:RNA primer-DNA primerPre-replicative complexRFC37UbiquitinRNA PrimerPhosphorylated Cdc6with the replication fork5. Leading/lagging strand synthesisRNA primer-DNA primer:origin duplex:PCNAMcm 4,6,7 trimer forms and associatesATPDegraded by proteasome in cytosolOrc4RFC Heteropentamer:RNA primer-DNA primer:UbiquitinMcm5Orc ComplexCdc6ATPMcm6p70DNA polymerase alpha: primase: origin complexDNA polymerase alpha: primase: origin complexPCNA homotrimer1. Assembly of the pre-replicative complexMcm6ADPaUbiquitinated Cdc6Mcm4Cdc6Orc2ATPRNA primer-DNA primerProcessive complexATPOrc3dCTPRFC40Mcm3RFC36CTPPhosphorylated Orc1Orc3Cdc6Orc4Mcm3dGTPCdc6Orc5Orc2Orc complexOrc2Orc1Mcm2Orc34. Switching of origins to post-replicative stateCdt1GemininOrc5Cdt1UTPOrc complexMcm5Mcm10RFC140Mcm2Cdt1OriginPhosphorylation of Mcm 2-7 complexMcm7DNA PolymeraseOrc complexUbiquitinated Orc1Orc complexOrc23. DNA replication initiationDegraded by proteasome in cytosolOrc3Mcm4orc-2ubq-2F08B4.5F34D10.2mcm-6ORC5LORC6LRPA2CDC7GMNNF33H2.5CDT1RPA1Y47D3A.29RFC4Y39A1A.12cdc-6ARPAORC4LASKPOLD4CDC46rfc-2RPA3CDK2pri-2POLD2mcm-7F10C2.4PCNArfc-1ORC3LRPA4mcm-4POLD3pri-1rfc-3mcm-2div-1Y47D3A.28ubq-1mcm-3


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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