Selenium micronutrient network (Homo sapiens)

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1185185, 34, 83, 100, 109...159102, 140, 159, 26481, 21138, 94, 118, 1901186298, 23380, 153, 23829142152, 23732, 10023338, 50, 125, 21520223Process or metabolism involved in Se PathwayLipid peroxidationProstaglandins metabolismConversionBiomarker forProtein tyrosine nitrationGlycogenesisBindingTryptophan metabolismLeukotriene metabolismMicronutrientsCofactorsLEGENDFrom intracellular part to the plasmaCatalysisis composed ofInflammation and immune responseSelenium statusTranscription factorCleavageSelenoproteinsLipoprotein melabolismStimulationCofactor conversionNecessary stimulationMetabolitesReactionMetabolic stressCa++ metabolismEnzymesOther proteinsInhibitionNegative EffectStatusOverarching processOxidative stressIntracellularER protein foldingNAD+ metabolismGlutathione metabolismDNA oxidationFolate metabolismPlasmaMDADPAPGH3PGE2PGF2aLipoxin B4PGH2COX2PGI2Lipoxin A4DGLAThromboxane A2DHACOX1PGI2Lipoxin B48-Isoprostaglandin F2aThromboxane B2Thromboxane B2Linoleic acidNFkB2DPAPGE3F2-Isoprostanea-Tocopherola-TocopherolLinoleic acidLipoxin A4EPAArachidonic acidPGE1F2-IsoprostanePGE2NFkB1MDAPGD2Arachidonic acidPGD2EPAALAPGF2a8-Isoprostaglandin F2aRELAPGG2DHAALAPGE16, 22, 175, 180, 2441131126, 22, 129, 175, 180...24911211332252113218262167, 221, 26299, 26275, 156218119, 16625222118626226211257, 86, 105, 1121, 26232249, 2528621849, 1122185, 6, 34, 57, 86...221119, 166262119, 16626210575, 105, 113, 156, 186113249249, 25275, 15648, 262Kynurenine98MTR18, 69TRXR1CBS17, 69IodineIodine213213KMO9815-HETEThyroxine (T4)5-HETETriiodothyronine (T3)R-Triiodothyronine (rT3)5,6-EpoxytetraeneThyroxine (T4)5-HPETETriiodothyronine (T3)15-HETER-Triiodothyronine (rT3)5-HETE212, 21323, 21223, 21261, 186, 25923, 21261, 186, 259186, 218212, 213218212, 21361, 186, 259186NADP+MPOCatalaseMPO117, 154, 190, 198118, 158190Uric acid81, 171CysteinePAI-1Factor VIIGGT1ThrombinPLGPLGFactor VIIPAI-1ThrombintPAtPA25020315, 22520320315, 22520320316, 22520316, 225GPX 4TRXR2Xantine oxidase28, 171PRDX5H2O2ALOX5ALOX15B120, 18612, 22, 34, 109, 218CopperUric acid81, 171Vitamin B12134, 2475,10-Methylene-THFSelR66, 94Tryptophan98, 2335-methyl-THFSOD3PRDX1RFK4H2OGPX 3NiacinamideCTH69PNPO123Heme17, 29, 118, 158, 167NADPHLipoic acid264ManganeseFAD10Methionine sulfoxide94Dehydroascorbic acid85, 102Leukotriene A479, 82NADPHFAD10THFHydroxykynurenine98Folic acid18NADP+NADPHSeleniumSelenium145145Sep15SelK738, 130, 215GPX 6GSH136Nicotinamidase233Calcium82Methionine94ManganeseNADPHFolic acid18FMN10SelenideSelenocysteineSelenophosphate140, 212140, 212140, 212CysteineLeukotriene C4Leukotriene C482, 250GPX 3200Dehydroascorbic acid102GPX 2SelP39Trx-S2102, 159, 264Ascorbic acid85Lipoic acid264PRDX4GPX 1NADP+HomocysteineRNSROS7, 20, 25, 28, 35...118, 142NADPHVitamin B12134, 247MTHFR18Homocysteine15SelTSelVDIO2SelNDIO1SelOSelHSelMSelSSelPSelISPS2DIO335, 39, 116, 2418772, 96, 12580, 8720, 239196, 212, 213212, 213212, 213212, 2278787, 153, 2388750, 161, 242SOD1Pyridoxal 5'-phosphate98SerineIron82HypoxanthinePRDX3GSR216HDL-CABCA1APOA1-NO2TyrHDL/SAAAPOA1LDLVLDLSAA2LDLRCholesterolVLDLSAA1oxLDLLDLVLDL/APOBACTCholesterolHDL-CHDL/APOA1SAA4VLDL-TAGHDLAPOBTAGSRB1APOBVLDL-TAGTAGACTSAA3FMNAPOA1oxLDLHDL47, 137, 20856, 152152, 183100, 117, 129, 237, 2551521521261015256126152, 183126, 256100, 117, 129, 237, 255126100, 117, 237, 255126126152230126152126126, 25615256, 152, 183152152, 183137100, 117, 237, 25547, 137, 208152152, 183152O232Pyridoxal 5'-phosphate988-OHdGFAD8-OHdG22322310PRDX2ADPLeukotriene D4Leukotriene D4250ChlorineCopperChlorineCystathionineFAD10SOD2Dihydrolipoate207, 264SerineNADP+ATPZincNADP+GSSGNADPHZincNiacinLeukotriene B4Leukotriene B479, 8279Quinolinic Acid98, 233PMPNONOHOClNO2HNO2O3154, 198154, 198NADP+GSH20, 79, 136FibrinTNFaFLAPTNFaIL6HbA1cIL1BIL1BCCL2HbA1cINSALBFibrinHBBsICAM-1ALBIFNgIL6HBA1INSFibrinogensICAM-1D-dimerINSRIL10CRPIL10IFNgCCL2FibrinogenD-dimer1213196100, 129, 133, 236201161164, 203116, 150, 1611324116, 20316124158, 62, 173, 240201205201116, 189, 196141, 241196, 205, 236164, 203133, 177, 189205141, 24158, 62, 173, 240, 25616, 203133, 177, 189141, 150, 161, 18919658, 173201SelW25, 46, 136Riboflavin128SOD3211TRXR1159Ascorbate85, 102O2 · –XanthineCalcium82Kynureninase98Methionine94ADPTrx-(SH)2159, 264ONOO–/ONOOHNitrotyrosineNitrotyrosine142142ATPLeukotriene E4Leukotriene E4250FructosamineLeukotriene F4FructosamineGlucose13243, 2501362, 201Iron82HypoxanthineTRXR3FLAD14, 67Ascorbic acid85, 175, 244


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  240. Lavie CJ, Milani RV, Mehra MR, Ventura HO; ''Omega-3 polyunsaturated fatty acids and cardiovascular diseases.''; J Am Coll Cardiol, 2009 PubMed Europe PMC Scholia
  241. Leonard S, Arbogast D, Geyer D, Jones C, Sinensky M; ''Localization of the gene encoding 3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome 5.''; Proc Natl Acad Sci U S A, 1986 PubMed Europe PMC Scholia
  242. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R; ''A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis.''; Clin Rheumatol, 2003 PubMed Europe PMC Scholia
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  244. Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A; ''Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  245. Proctor PH.; ''Free radicals, uric acid, and human disease.''; Free Radic Biol Med., 1996 PubMed Europe PMC Scholia
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  247. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
  248. Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN; ''Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
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  250. Deo AK, Bandiera SM; ''Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid.''; Drug Metab Dispos, 2008 PubMed Europe PMC Scholia
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  252. Yamauchi Y, Reid PC, Sperry JB, Furukawa K, Takeya M, Chang CC, Chang TY; ''Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.''; J Biol Chem, 2007 PubMed Europe PMC Scholia
  253. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, Yamamoto M, Kumasaka T, Miyano M, Kai Y, Urade Y; ''Mechanism of metal activation of human hematopoietic prostaglandin D synthase.''; Nat Struct Biol, 2003 PubMed Europe PMC Scholia
  254. Hansel A, Heinemann SH, Hoshi T; ''Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation.''; Biochim Biophys Acta, 2005 PubMed Europe PMC Scholia
  255. Bleys J, Navas-Acien A, Guallar E; ''Serum selenium and diabetes in U.S. adults.''; Diabetes Care, 2007 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
125000view06:55, 12 January 2023SusanRemoved fill colors for the pathways listed
123380view11:44, 21 July 2022DeSlRemoved not UTF-8 encoded symbols for Hyperoxid
121694view03:28, 26 February 2022EweitzFix gene symbol
120903view14:04, 29 January 2022EgonwReplaced an old HMDB identifier with the current one
118387view13:57, 27 May 2021Marvin M2removed empty refs
117822view14:56, 22 May 2021EweitzModified title
107118view14:19, 17 September 2019MaintBotChEBI identifier normalization
106694view13:04, 17 September 2019MaintBotHMDB identifier normalization
106489view21:41, 4 September 2019KhanspersModified description
105808view22:53, 15 August 2019KhanspersModified description
105140view15:25, 10 July 2019DeSlConverted unconnected lines into graphical lines (if applicable).
105136view14:54, 10 July 2019DeSlUpdated Fibrinogen as complex with 3 subunits, changed fibrin datanode type from protein to metabolite.
98241view14:04, 14 August 2018EgonwReplace a PubChem SID with a Wikidata ID (which has more links out).
96720view21:55, 30 March 2018AlexanderPicoModified description
96318view09:09, 8 March 2018Mkutmonremove outdated pathway attributes
96278view08:13, 5 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96250view14:07, 2 March 2018EgonwFixed a character encoding issue.
96249view14:06, 2 March 2018EgonwIt had the PubChem CID from the start, but that entry is not the protein fibrin, but a small compound. I now took the Wikidata entry matching the proper Wikipedia page.
94185view13:59, 25 August 2017Mkutmonadded missing metabolite identifiers
94106view09:54, 21 August 2017DeSlConnected 3 more unconnected lines.
94105view09:52, 21 August 2017DeSlConnected unconnected lines.
93691view15:50, 9 August 2017DeSlModified description
88908view08:53, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
85060view11:16, 10 April 2016Egonw
82705view08:55, 23 October 2015EgonwMissed one oxLDL :(
82703view08:43, 23 October 2015EgonwoxLDL has a separate identifier.
82689view15:29, 22 October 2015EgonwRemoved HMDB00464 from iodine and iron data nodes.
79870view14:46, 21 April 2015Mkutmonremoved invalid annotation for "Fibrinogen" (Database: Other)
78776view23:23, 26 January 2015AlexanderPicoreplacing legend datanodes with shapes
78775view23:15, 26 January 2015AlexanderPicoreplacing legend datanode with shape
73505view23:16, 29 January 2014KhanspersModified title
73504view23:14, 29 January 2014KhanspersModified title
73357view04:57, 23 January 2014MaintBotfixed character representation of hyphen in gpml
72365view09:35, 13 November 2013EgonwFixed the type of two proteins.
71706view19:58, 17 October 2013MaintBotUpdated data sources
70119view19:19, 12 July 2013MaintBotupdated to 2013 schema
68043view11:14, 29 June 2013EgonwAdded two missing metabolite identifiers.
68041view11:08, 29 June 2013EgonwUndo revision 68036 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68040view11:07, 29 June 2013EgonwUndo revision 68037 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68039view11:06, 29 June 2013EgonwUndo revision 68038 by [[Special:Contributions/Egonw|Egonw]] ([[User talk:Egonw|Talk]])
68038view11:02, 29 June 2013EgonwRemoved a few empty, unlinked gene product data nodes.
68037view10:58, 29 June 2013EgonwRemoved an empty unlinked 'protein'.
68036view10:57, 29 June 2013EgonwRemoved an empty unlinked 'metabolite'.
68035view10:49, 29 June 2013EgonwFixed EC number data source.
61689view22:06, 16 April 2013MaintBotremoved data source without identifer
56489view09:45, 8 January 2013EgonwFixed DataNode @Type from Metabolite to Protein for those with an Entrez Gene identifier.
54708view14:04, 7 December 2012AndraRDF Tidy
48242view06:08, 17 May 2012MaintBotUpdating PubChem xrefs
48216view05:28, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45021view18:39, 6 October 2011ThomasOntology Term : 'selenoamino acid metabolic pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Metabolite
15-HETEMetaboliteHMDB03876 (HMDB) 15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
5,10-Methylene-THFMetaboliteHMDB01533 (HMDB) 5,10-Methylenetetrahydrofolate
5,6-EpoxytetraeneMetaboliteC14815 (Kegg Compound)
5-HETEMetaboliteHMDB11134 (HMDB) 5-hydroxyeicosatetraenoic acid
5-HPETEMetaboliteHMDB01193 (HMDB) 5(S)-Hydroperoxyeicosatetraenoic acid
5-methyl-THFMetaboliteHMDB01396 (HMDB) 5-methyltetrahydrofolate
8-Isoprostaglandin F2aMetaboliteHMDB05083 (HMDB)
8-OHdGMetaboliteHMDB03333 (HMDB) 8-Hydroxy-deoxyguanosine
ABCA1Protein19 (Entrez Gene) ATP-binding cassette, sub-family A (ABC1), member 1
ACTProtein12 (Entrez Gene)
  • alpha-1-antichymotrypsin
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
ADPMetaboliteHMDB01341 (HMDB) Adenosine diphosphate
ALAMetaboliteHMDB01388 (HMDB) Alpha-Linolenic acid
ALBProtein213 (Entrez Gene) albumin
ALOX15BProtein247 (Entrez Gene)
  • EC 1.13.11.33
  • arachidonate 15-lipoxygenase, type B
ALOX5Protein240 (Entrez Gene)
  • EC 1.13.11.34
  • arachidonate 5-lipoxygenase
APOA1-NO2TyrProtein335 (Entrez Gene) Nitrotyrosinated apolipoprotein A-I
APOA1Protein335 (Entrez Gene) apolipoprotein A-I
APOBProtein338 (Entrez Gene) apolipoprotein B
ATPMetaboliteHMDB00538 (HMDB) Adenosine triphosphate
Arachidonic acidMetaboliteHMDB01043 (HMDB)
AscorbateMetabolite38290 (ChEBI)
Ascorbic acidMetabolite29073 (ChEBI)
CBSProtein875 (Entrez Gene)
  • EC 4.2.1.22
  • cystathionine-beta-synthase
CCL2Protein6347 (Entrez Gene) chemokine (C-C motif) ligand 2
COX1Protein5742 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 1
  • COX-1 constitutive
COX2Protein5743 (Entrez Gene)
  • EC 1.14.99.1
  • Cyclooxygenase 2
  • COX-2 inducible
CRPProtein1401 (Entrez Gene) C-reactive protein, pentraxin-related
CTHProtein1491 (Entrez Gene)
  • EC 4.4.1.1
  • cystathionase
CalciumMetaboliteHMDB00464 (HMDB)
CatalaseProtein847 (Entrez Gene) EC 1.11.1.6
ChlorineMetaboliteHMDB00492 (HMDB)
CholesterolMetaboliteHMDB00067 (HMDB)
CopperMetaboliteHMDB00657 (HMDB)
CystathionineMetaboliteHMDB00099 (HMDB)
CysteineMetaboliteHMDB00574 (HMDB)
D-dimerProteinhttp://en.wikipedia.org/wiki/Fibrin_degradation_product
DGLAMetaboliteHMDB02925 (HMDB)
  • Dihomo-gamma-linolenic acid
  • 8,11,14-Eicosatrienoic acid
DHAMetaboliteHMDB02183 (HMDB) Docosahexaenoic acid
DIO1Protein1733 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type I
DIO2Protein1734 (Entrez Gene)
  • EC 1.97.1.10
  • Selenoprotein-deiodinase, iodothyronine, type II
DIO3Protein1735 (Entrez Gene)
  • EC 1.97.1.11
  • Selenoprotein-deiodinase, iodothyronine type III
DPAMetaboliteHMDB01976 (HMDB) Docosapentaenoic acid
Dehydroascorbic acidMetabolite17242 (ChEBI)
DihydrolipoateMetaboliteHMDB12210 (HMDB)
EPAMetaboliteHMDB01999 (HMDB) Eicosapentaenoic acid
F2-IsoprostaneMetabolite53788444 (PubChem-substance)
FADMetaboliteHMDB01248 (HMDB) Flavin adenine dinucleotide
FLAD1Protein80308 (Entrez Gene)
  • EC 2.7.7.2
  • FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
FLAPProtein241 (Entrez Gene) arachidonate 5-lipoxygenase-activating protein
FMNMetaboliteHMDB01520 (HMDB) Flavin Mononucleotide
Factor VIIProtein2155 (Entrez Gene)
  • EC 3.4.21.21
  • coagulation factor VII (serum prothrombin conversion accelerator)
FibrinMetabolite439199 (PubChem-compound)
FibrinogenProteinGO:0005577 (Other)
Folic acidMetaboliteHMDB00121 (HMDB)
FructosamineMetaboliteHMDB02030 (HMDB)
GGT1Protein2678 (Entrez Gene)
  • EC 2.3.2.2
  • gamma-glutamyltransferase 1
GPX 1Protein2876 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 1
GPX 2Protein2877 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 2
GPX 3Protein2878 (Entrez Gene) Selenoprotein-glutathione peroxidase 3
GPX 4Protein2879 (Entrez Gene)
  • EC 1.11.1.12
  • Selenoprotein-glutathione peroxidase 4
GPX 6Protein257202 (Entrez Gene)
  • EC 1.11.1.9
  • Selenoprotein-glutathione peroxidase 6
GSHMetaboliteHMDB00125 (HMDB) Glutathione
GSRProtein2936 (Entrez Gene)
  • EC 1.8.1.7
  • glutathione reductase
GSSGMetaboliteHMDB00656 (HMDB) Glutathione disulfide
GlucoseMetaboliteHMDB00122 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB) Hydrogen peroxide
H2OMetaboliteHMDB02111 (HMDB) Glutathione disulfide
HBA1Protein3039 (Entrez Gene) hemoglobin, alpha 1
HBBProtein3043 (Entrez Gene) hemoglobin, beta
HDL-CMetabolite47775 (ChEBI) high-density lipoprotein cholesterol
HDL/APOA1Metabolite39025 (ChEBI)
  • high-density lipoprotein
  • ApoA-I is present on the majority of HDL particles and constitutes aprox 70% of the apolipoprotein content of HDL particles
HDL/SAAMetabolite39025 (ChEBI)
  • high-density lipoprotein
  • SAA circulates in plasma as a constituent of high density lipoproteins (HDL).
HDLMetabolite39025 (ChEBI) high-density lipoprotein
HNO2Metabolite25567 (ChEBI) Nitrous acid
HOClMetaboliteHMDB01050 (HMDB) Hypochlorite
HbA1cProtein
  • Glycated hemoglobin
  • http://en.wikipedia.org/wiki/Glycated_hemoglobin
HemeMetaboliteHMDB03178 (HMDB)
HomocysteineMetaboliteHMDB00742 (HMDB)
HydroxykynurenineMetaboliteHMDB00732 (HMDB)
HypoxanthineMetaboliteHMDB00157 (HMDB)
IFNgProtein3458 (Entrez Gene) interferon, gamma
IL10Protein3458 (Entrez Gene) interferon, gamma
IL1BProtein3553 (Entrez Gene) interleukin 1, beta
IL6Protein3569 (Entrez Gene) interleukin 6 (interferon, beta 2)
INSProtein3630 (Entrez Gene) Insulin
INSRProtein3643 (Entrez Gene) Insulin receptor
IodineMetaboliteHMDB00464 (HMDB)
IronMetaboliteHMDB00464 (HMDB)
IronMetaboliteHMDB00692 (HMDB)
KMOProtein8564 (Entrez Gene)
  • EC 1.14.13.9
  • kynurenine 3-hydroxylase
KynureninaseProtein8942 (Entrez Gene) EC 3.7.1.3
KynurenineMetaboliteHMDB00684 (HMDB)
LDLMetabolite39026 (ChEBI) low-density lipoprotein
LDLRProtein3949 (Entrez Gene) low density lipoprotein receptor
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
Leukotriene F4MetaboliteHMDB06465 (HMDB)
Linoleic acidMetaboliteHMDB00673 (HMDB)
Lipoic acidMetaboliteHMDB01451 (HMDB)
Lipoxin A4MetaboliteHMDB04385 (HMDB)
Lipoxin B4MetaboliteHMDB05082 (HMDB)
MDAMetaboliteHMDB06112 (HMDB) Malondialdehyde
MPOProtein4353 (Entrez Gene)
  • EC 1.11.1.7
  • Myeloperoxidase
MTHFRProtein4524 (Entrez Gene)
  • EC 1.5.1.20
  • 5,10-methylenetetrahydrofolate reductase
MTRProtein4548 (Entrez Gene)
  • EC 2.1.1.13
  • 5-methyltetrahydrofolate-homocysteine methyltransferase
ManganeseMetaboliteHMDB01333 (HMDB)
Methionine sulfoxideMetaboliteHMDB02005 (HMDB)
MethionineMetaboliteHMDB00696 (HMDB)
NADP+MetaboliteHMDB00217 (HMDB) Nicotinamide adenine dinucleotide phosphate-Oxidized
NADPHMetaboliteHMDB00221 (HMDB) Nicotinamide adenine dinucleotide phosphate-Reduced
NFkB1GeneProduct4790 (Entrez Gene) nuclear factor NF-kappa-B p50 subunit
NFkB2GeneProduct4791 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
NO2Metabolite33101 (ChEBI) Nitrogen dioxide
NOMetaboliteHMDB03378 (HMDB) Nitric oxide
NiacinMetaboliteHMDB01488 (HMDB)
NiacinamideMetaboliteHMDB01406 (HMDB)
NicotinamidaseProtein3.5.1.19 (ec-code) Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3 GO:0008936
NitrotyrosineMetaboliteHMDB01904 (HMDB)
O2 · –MetaboliteHMDB02168 (HMDB) Superoxide
O2MetaboliteHMDB01377 (HMDB)
O3Metabolite25812 (ChEBI) ozone
ONOO–/ONOOHMetaboliteHMDB02179 (HMDB) Peroxynitrite
PAI-1Protein5054 (Entrez Gene) Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
PGD2MetaboliteHMDB01403 (HMDB) Prostaglandin D2
PGE1MetaboliteHMDB01442 (HMDB) Prostaglandin E1
PGE2MetaboliteHMDB01220 (HMDB) Prostaglandin E2
PGE3MetaboliteHMDB02664 (HMDB) Prostaglandin E3
PGF2aMetaboliteHMDB01139 (HMDB) Prostaglandin F2a
PGG2MetaboliteHMDB03235 (HMDB) Prostaglandin G2
PGH2MetaboliteHMDB01381 (HMDB) Prostaglandin H2
PGH3MetaboliteProstaglandin H3
PGI2MetaboliteHMDB01335 (HMDB) Prostaglandin I2
PLGProtein5340 (Entrez Gene)
  • EC 3.4.21.7
  • Plasminogen
PMPMetaboliteHMDB01555 (HMDB) Pyridoxamine 5'-phosphate
PNPOProtein55163 (Entrez Gene)
  • EC 1.4.3.5
  • pyridoxamine 5'-phosphate oxidase
PRDX1Protein5052 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 1
PRDX2Protein7001 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 2
PRDX3Protein10935 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 3
PRDX4Protein10549 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 4
PRDX5Protein25824 (Entrez Gene)
  • EC 1.11.1.15
  • peroxiredoxin 5
Pyridoxal 5'-phosphateMetaboliteHMDB01491 (HMDB)
Quinolinic AcidMetaboliteHMDB00232 (HMDB)
R-Triiodothyronine (rT3)Metabolite28774 (ChEBI) Reverse triiodothyronine
RELAGeneProduct5970 (Entrez Gene) nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
RFKProtein55312 (Entrez Gene)
  • EC 2.7.1.26
  • riboflavin kinase
RNSMetabolite
  • reactive nitrogen species
  • http://en.wikipedia.org/wiki/Reactive_nitrogen_species
ROSMetabolite26523 (ChEBI)
  • reactive oxygen species
  • http://en.wikipedia.org/wiki/Reactive_Oxygen_Species
RiboflavinMetaboliteHMDB00244 (HMDB)
SAA1Protein6288 (Entrez Gene) serum amyloid A1
SAA2Protein6289 (Entrez Gene) serum amyloid A2
SAA3Protein6290 (Entrez Gene) serum amyloid A3 pseudogene
SAA4Protein6291 (Entrez Gene) serum amyloid A4, constitutive
SOD1Protein6647 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 1, soluble
SOD2Protein6648 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 2, mitochondrial
SOD3Protein6649 (Entrez Gene)
  • EC 1.15.1.1
  • superoxide dismutase 3, extracellular
SPS2Protein22928 (Entrez Gene)
  • EC2.7.9.3
  • Selenoprotein-selenophosphate synthetase 2
SRB1Protein949 (Entrez Gene) scavenger receptor class B, member 1
SelHProtein280636 (Entrez Gene) Selenoprotein-selenoprotein H-chromosome 11 open reading frame 31
SelIProtein85465 (Entrez Gene)
  • Selenoprotein-selenoprotein I
  • Unknown function
SelKProtein58515 (Entrez Gene) Selenoprotein-selenoprotein K
SelMProtein140606 (Entrez Gene) Selenoprotein-selenoprotein M
SelNProtein57190 (Entrez Gene) Selenoprotein-selenoprotein N, 1
SelOProtein83642 (Entrez Gene)
  • Selenoprotein-selenoprotein O
  • Unknown function
SelPProtein6414 (Entrez Gene) Selenoprotein-selenoprotein P
SelRMetabolite51734 (Entrez Gene)
  • EC 1.8.4.-
  • Selenoprotein-selenoprotein X
SelSProtein55829 (Entrez Gene) Selenoprotein-selenoprotein S
SelTProtein51714 (Entrez Gene) Selenoprotein-selenoprotein T
SelVProtein348303 (Entrez Gene)
  • Selenoprotein-selenoprotein V
  • Unknown function
SelWMetabolite6415 (Entrez Gene) Selenoprotein-selenoprotein W
SelenideMetabolite15076 (ChEBI)
SeleniumMetaboliteHMDB01349 (HMDB)
SelenocysteineMetaboliteHMDB03288 (HMDB)
SelenophosphateMetabolite16144 (ChEBI)
Sep15Protein9403 (Entrez Gene) Selenoprotein-15 kDa selenoprotein
SerineMetaboliteHMDB00187 (HMDB)
TAGMetabolite17855 (ChEBI)
  • Triglyceride
  • Triacylglycerol
THFMetaboliteHMDB01846 (HMDB) Tetrahydrofolic acid
TNFaProtein7124 (Entrez Gene) tumor necrosis factor (TNF superfamily, member 2)
TRXR1Protein7296 (Entrez Gene) Selenoprotein-thioredoxin reductase 1
TRXR2Protein10587 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 2
TRXR3Protein114112 (Entrez Gene)
  • EC 1.8.1.9
  • Selenoprotein-thioredoxin reductase 3
ThrombinProtein2147 (Entrez Gene)
  • EC 3.4.21.5
  • coagulation factor II (thrombin)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)
Thyroxine (T4)Metabolite30660 (ChEBI)
Triiodothyronine (T3)Metabolite18258 (ChEBI)
Trx-(SH)2Protein7295 (Entrez Gene) reduced thioredoxin
Trx-S2Protein7295 (Entrez Gene) oxidized thioredoxin
TryptophanMetaboliteHMDB00929 (HMDB)
Uric acidMetaboliteHMDB00289 (HMDB)
VLDL-TAGMetabolite47776 (ChEBI)
  • very-low-density lipoprotein-triglyceride
  • Triglyceride transport
VLDL/APOBMetabolite39027 (ChEBI)
  • very-low-density lipoprotein
  • The VLDL is produced in the liver, contains one molecule of apoB100
VLDLMetabolite39027 (ChEBI) very-low-density lipoprotein
Vitamin B12MetaboliteHMDB02174 (HMDB)
XanthineMetaboliteHMDB00292 (HMDB)
Xantine oxidaseProtein7498 (Entrez Gene)
  • EC 1.17.3.2
  • http://en.wikipedia.org/wiki/Xanthine_oxidase
ZincMetaboliteHMDB01303 (HMDB)
a-TocopherolMetaboliteHMDB01893 (HMDB)
oxLDLMetabolite39026 (ChEBI) oxidized low-density lipoprotein
sICAM-1Protein3383 (Entrez Gene) soluble intercellular adhesion molecule 1
tPAProtein5327 (Entrez Gene)
  • EC 3.4.21.68
  • plasminogen activator, tissue

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP15"
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