DNA replication (Caenorhabditis elegans)

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1. Assembly of the pre-replicative complexPhosphorylation of Mcm 2-7 complexADPdUTP3. DNA replication initiationMcm7ATPOrc3Orc5RFC Heteropentamer:RNA primer-DNA primer:5. Leading/lagging strand synthesisADPOrc5OriginRFC40Phosphorylated Orc1Mcm6Phosphorylated Cdc6Orc3RFC Heteropentamer:RNA primer-DNA primerOrc14. Switching of origins to post-replicative stateDegraded by proteasome in cytosolCdt1Orc complexPrimaseDNA polymerase alpha: primase: origin complexRFC140Orc4Orc3p70Mcm2Cdc6GemininMcm3Orc2RNA primer-DNA primer:origin duplex:PCNAUbiquitinMcm2DNA polymerase alpha: primase: origin complexUbiquitinated Cdc6Cdt1PCNA homotrimerOrc2CTPMcm10Mcm4RNA PrimerOrc ComplexRNA primer-DNA primer2. Activation of the pre-replicative complexProcessive complexOrc5aMcm4UTPUbiquitinated Orc1Orc2with the replication forkp49UbiquitinOrc complexCdt1Cdc6ATPdCTPCdt1dATPMcm5Orc4Mcm 4,6,7 trimer forms and associatesPre-replicative complexdGTPCdt1Degraded by proteasome in cytosolp58Cdc6RFC38DNA PolymeraseOrc2Orc complexp180Orc complexMcm7GTPMcm6Orc3Pre-replicative complexRFC36Mcm5ATPATPCdc6Mcm3RFC37RNA primer-DNA primerCDK2div-1F10C2.4pri-1RPA1ORC3LF08B4.5ubq-2rfc-1CDC46orc-2ARPAASKPOLD4mcm-3PCNARPA3ORC6LORC5LF34D10.2mcm-4F33H2.5ORC4Lmcm-2pri-2cdc-6POLD3Y39A1A.12ubq-1RPA2GMNNRFC4mcm-7Y47D3A.28CDT1rfc-2CDC7rfc-3Y47D3A.29mcm-6POLD2RPA4


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Ontology Terms

 

Bibliography

  1. Brauchle M, Baumer K, Gönczy P; ''Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.''; Curr Biol, 2003 PubMed Europe PMC Scholia
  2. Rose A.; ''Replication and repair''; WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook, 2014 DOI Scholia

History

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CompareRevisionActionTimeUserComment
125278view16:10, 31 January 2023LarsgwAdd DOI to publication
118534view11:08, 28 May 2021DeSlAdded 2 lit. refs
118433view14:37, 27 May 2021UlasBabayigitConnected all lines to their nodes/labels
118149view10:40, 25 May 2021EweitzModified title
80063view08:51, 4 May 2015EgonwUbiquitin is a protein.
72573view12:17, 23 November 2013EgonwAdded a bunch of missing metabolite identifiers.
67161view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62522view12:40, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62521view12:36, 29 April 2013EgonwConverted a label into a Metabolite DataNode.
62518view11:57, 29 April 2013EgonwConnecting dots.
40644view19:58, 1 March 2011MaintBotRemoved redundant pathway information and comments
35213view15:45, 11 February 2010ThomasModified description
35201view15:40, 11 February 2010ThomasModified description
21083view11:30, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:DNA replication Reactome]] moved to [[Pathway:WP192]]: Moved to stable identifier
8498view14:00, 7 January 2008MaintBotAdded to category $category
19414view14:00, 7 January 2008D.KorenUploaded new pathway
8496view14:00, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARPAGeneProduct176131 (Entrez Gene)
ASKGeneProduct (Entrez Gene)
CDC46GeneProduct175552 (Entrez Gene)
CDC7GeneProduct (Entrez Gene)
CDK2GeneProduct (Entrez Gene)
CDT1GeneProduct (Entrez Gene)
CTPMetabolite
F08B4.5GeneProduct177673 (Entrez Gene)
F10C2.4GeneProduct179652 (Entrez Gene)
F33H2.5GeneProduct173368 (Entrez Gene)
F34D10.2GeneProduct175481 (Entrez Gene)
GMNNGeneProduct (Entrez Gene)
ORC3LGeneProduct (Entrez Gene)
ORC4LGeneProduct (Entrez Gene)
ORC5LGeneProduct (Entrez Gene)
ORC6LGeneProduct (Entrez Gene)
PCNAGeneProduct (Entrez Gene)
POLD2GeneProduct (Entrez Gene)
POLD3GeneProduct (Entrez Gene)
POLD4GeneProduct (Entrez Gene)
RFC4GeneProduct (Entrez Gene)
RPA1GeneProduct (Entrez Gene)
RPA2GeneProduct (Entrez Gene)
RPA3GeneProduct (Entrez Gene)
RPA4GeneProduct (Entrez Gene)
Y39A1A.12GeneProduct176486 (Entrez Gene)
Y47D3A.28GeneProduct176562 (Entrez Gene)
Y47D3A.29GeneProduct176544 (Entrez Gene)
cdc-6GeneProduct172029 (Entrez Gene)
div-1GeneProduct176439 (Entrez Gene)
mcm-2GeneProduct174841 (Entrez Gene)
mcm-3GeneProduct180010 (Entrez Gene)
mcm-4GeneProduct171793 (Entrez Gene)
mcm-6GeneProduct176385 (Entrez Gene)
mcm-7GeneProduct178831 (Entrez Gene)
orc-2GeneProduct174676 (Entrez Gene)
pri-1GeneProduct176358 (Entrez Gene)
pri-2GeneProduct173122 (Entrez Gene)
rfc-1GeneProduct179967 (Entrez Gene)
rfc-2GeneProduct176946 (Entrez Gene)
rfc-3GeneProduct178259 (Entrez Gene)
ubq-1GeneProduct175840 (Entrez Gene)
ubq-2GeneProduct176718 (Entrez Gene)

Annotated Interactions

No annotated interactions
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