Drug induction of bile acid pathway (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. NGP E-Magazine; ''Mechanistic Disease Modeling''; http://www.ngpharma.com/article/Mechanistic-Disease-Modeling/, 2012

History

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Compare	Revision	Action	Time	User	Comment
	141430	view	11:44, 14 November 2025	DeSl	Added missing ID for BA-R (assumed to be Bile-acid with any sidechain
	141368	view	03:56, 11 November 2025	Eweitz	Clear deprecated metadata rendering
	128660	view	04:11, 18 February 2024	Eweitz	Ontology Term : 'hepatocyte' added !
	128659	view	04:04, 18 February 2024	Eweitz	Use gene symbols, economize layout
	120498	view	07:29, 9 December 2021	Egonw	Replaced an old PubChem CID with the new one
	117705	view	12:26, 22 May 2021	Eweitz	Modified title
	106211	view	12:10, 16 August 2019	MaintBot	HMDB identifier normalization
	97831	view	06:27, 10 June 2018	Egonw	Modified description
	97745	view	13:07, 7 June 2018	Roelod	Modified description
	97743	view	13:05, 7 June 2018	Roelod	Modified description
	88593	view	19:40, 11 August 2016	Mkutmon	fix unconnected lines
	87242	view	09:57, 20 July 2016	Susan	Ontology Term : 'bile acid signaling pathway' added !
	87241	view	09:56, 20 July 2016	Susan	Ontology Term : 'drug pathway' added !
	78511	view	10:29, 7 January 2015	MaintBot	added missing graphIds
	70504	view	11:46, 8 August 2013	Egonw	Added a ChEBI id for the phospholipid compound class.
	68912	view	17:31, 8 July 2013	MaintBot	Updated to 2013 gpml schema
	60232	view	21:49, 14 March 2013	Egonw	Added a reference to ChEBI for 'bile acid'.
	57150	view	12:35, 23 January 2013	Egonw	Used "PubChem-compound"
	53119	view	01:34, 30 October 2012	MaintBot	Modified categories
	51078	view	14:40, 28 August 2012	Riannefijten	Added reference on which the pathway is based
	51077	view	14:32, 28 August 2012	Riannefijten	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ABCB11	GeneProduct	8647 (Entrez Gene)
ABCB1	GeneProduct	5243 (Entrez Gene)
ABCC2	GeneProduct	1244 (Entrez Gene)
ABCC3	GeneProduct	8714 (Entrez Gene)
ABCC4	GeneProduct	10257 (Entrez Gene)
BA-R	Metabolite
BAAT	GeneProduct	570 (Entrez Gene)
Bile Acids	Metabolite	CHEBI:3098 (ChEBI)
Bilirubin	Metabolite	HMDB00054 (HMDB)
CYP3A4	GeneProduct	1576 (Entrez Gene)
CYP7A1	GeneProduct	1581 (Entrez Gene)
Chlorpromazine	Metabolite	2726 (PubChem-compound)
Cholesterol	Metabolite	HMDB00067 (HMDB)
Cimetidine	Metabolite	2756 (PubChem-compound)
Clarithromyci	Metabolite	84029 (PubChem-compound)
Clozapine	Metabolite	2818 (PubChem-compound)
Colchicine	Metabolite	6167 (PubChem-compound)
Cyclosporin	Metabolite	5284373 (PubChem-compound)
Deoxycholic acid	Metabolite	HMDB00626 (HMDB)
Digoxin	Metabolite	HMDB01917 (HMDB)
Erythromycin	Metabolite	12560 (PubChem-compound)
Ezetimibe	Metabolite	150311 (PubChem-compound)
Glyburide	Metabolite	3488 (PubChem-compound)
Glycocholic acid	Metabolite	HMDB00138 (HMDB)
Isoursodeoxycholic acid	Metabolite	HMDB00686 (HMDB)
Methylprednisolone	Metabolite	6741 (PubChem-compound)
NR1H4	GeneProduct	9971 (Entrez Gene)
NR1I2	GeneProduct	8856 (Entrez Gene)
NR1I3	GeneProduct	9970 (Entrez Gene)
OSTBETA	GeneProduct	123264 (Entrez Gene)
OSTalpha	GeneProduct	200931 (Entrez Gene)
Oxiglutatione	Metabolite	65359 (PubChem-compound)
Phomin	Metabolite	5311281 (PubChem-compound)
Phospholipids	Metabolite	CHEBI:16247 (ChEBI)
Ranitidine	Metabolite	HMDB01930 (HMDB)
SLC10A1	GeneProduct	6554 (Entrez Gene)
SLCO1B1	GeneProduct	10599 (Entrez Gene)
SULT2A1	GeneProduct	6822 (Entrez Gene)
Silybin	Metabolite	31553 (PubChem-compound)
Tacrolimus	Metabolite	445643 (PubChem-compound)
Taurocholic acid	Metabolite	HMDB00036 (HMDB)
Tetrahydrocortisone	Metabolite	HMDB00903 (HMDB)
Trabectedin	Metabolite	108150 (PubChem-compound)
Troglitazone	Metabolite	5591 (PubChem-compound)
VDR	GeneProduct	7421 (Entrez Gene)

Annotated Interactions

No annotated interactions