NO/cGMP/PKG mediated neuroprotection (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

No bibliography

History

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Compare	Revision	Action	Time	User	Comment
	125786	view	10:03, 10 March 2023	DeSl	Converted PW node to current color scheme, added link for caspase cascade
	123318	view	07:41, 16 July 2022	Egonw	Typed a datanode
	117805	view	14:30, 22 May 2021	Eweitz	Modified title
	110707	view	14:19, 28 May 2020	Laurent	Added missing DataNode types - and one missing ID
	107157	view	14:24, 17 September 2019	MaintBot	ChEBI identifier normalization
	106656	view	21:17, 12 September 2019	Khanspers	Modified description
	105657	view	05:15, 10 August 2019	Khanspers	Modified description
	96448	view	09:26, 15 March 2018	Egonw	Replaced secondary ChEBI identifiers with primary identifiers.
	96378	view	06:46, 11 March 2018	Egonw	Replaced secondary ChEBI identifiers with primary identifiers.
	92677	view	11:02, 28 June 2017	SauerThorben	Ontology Term : 'signaling pathway involving second messengers' added !
	92676	view	11:01, 28 June 2017	SauerThorben	Ontology Term : 'signaling pathway' added !
	92675	view	11:01, 28 June 2017	SauerThorben	Ontology Term : 'neuron' added !
	92674	view	11:01, 28 June 2017	SauerThorben	Ontology Term : 'neural cell' added !
	92673	view	11:01, 28 June 2017	SauerThorben	Ontology Term : 'dementia' added !
	92672	view	09:59, 28 June 2017	SauerThorben	Modified title
	92671	view	09:57, 28 June 2017	SauerThorben	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
ACTN2	GeneProduct	ENSG00000077522 (Ensembl)
AKAP9	GeneProduct	ENSG00000127914 (Ensembl)
AMP	Metabolite	CHEBI:2356 (ChEBI)
ANP	GeneProduct	ENSG00000175206 (Ensembl)
Apoptosis
BAD	GeneProduct	ENSG00000002330 (Ensembl)
BCL2	GeneProduct	ENSG00000171791 (Ensembl)
BNP	GeneProduct	ENSG00000120937 (Ensembl)
CALM1	GeneProduct	ENSG00000198668 (Ensembl)
CAMK2A	GeneProduct	ENSG00000070808 (Ensembl)
CAMK2B	GeneProduct	ENSG00000058404 (Ensembl)
CAMK2D	GeneProduct	ENSG00000145349 (Ensembl)
CAMK2G	GeneProduct	ENSG00000148660 (Ensembl)
CASP9	GeneProduct	ENSG00000132906 (Ensembl)
CNGA1	GeneProduct	ENSG00000198515 (Ensembl)
CNGA2	GeneProduct	ENSG00000183862 (Ensembl)
CNGA3	GeneProduct	ENSG00000144191 (Ensembl)
CNGA4	GeneProduct	ENSG00000132259 (Ensembl)
CNGB1	GeneProduct	ENSG00000070729 (Ensembl)
CNGB3	GeneProduct	ENSG00000170289 (Ensembl)
CREB1	GeneProduct	ENSG00000118260 (Ensembl)
Ca2+	Metabolite	CHEBI:3308 (ChEBI)
Caspase Cascade
Cyclophilin D	GeneProduct	ENSG00000171497 (Ensembl)
Cytochrome C	GeneProduct	ENSG00000172115 (Ensembl)
DLG4	GeneProduct	ENSG00000132535 (Ensembl)
GRIN1	GeneProduct	ENSG00000176884 (Ensembl)
GRIN2A	GeneProduct	ENSG00000183454 (Ensembl)
GRIN2B	GeneProduct	ENSG00000273079 (Ensembl)
GRIN2C	GeneProduct	ENSG00000161509 (Ensembl)
GRIN2D	GeneProduct	ENSG00000105464 (Ensembl)
GTP	Metabolite	CHEBI:37565 (ChEBI)
GUCY1A2	GeneProduct	ENSG00000152402 (Ensembl)
GUCY1A3	GeneProduct	ENSG00000164116 (Ensembl)
GUCY1B2	GeneProduct	ENSG00000123201 (Ensembl)
GUCY1B3	GeneProduct	ENSG00000061918 (Ensembl)
IFN-Gamma	Protein	ENSG00000111537 (Ensembl)
IL-1B	Protein	ENSG00000125538 (Ensembl)
K+	Metabolite	CHEBI:29103 (ChEBI)
L-Arginine	Metabolite	16467 (ChEBI)
L-Citrulline	Metabolite	16349 (ChEBI)
L-Glutamate	Metabolite	CHEBI:16015 (ChEBI)
LPS		89981 (ChEBI)
Mg2+	Metabolite	CHEBI:6635 (ChEBI)
NADP	Metabolite	18009 (ChEBI)
NADPH	Metabolite	16474 (ChEBI)
NEFL	GeneProduct	ENSG00000277586 (Ensembl)
NFKB1	GeneProduct	ENSG00000109320 (Ensembl)
NFKB3	GeneProduct	ENSG00000173039 (Ensembl)
NFKBIA	GeneProduct	ENSG00000100906 (Ensembl)
NO	Metabolite	16480 (ChEBI)
NPR1	GeneProduct	ENSG00000169418 (Ensembl)
O2	Metabolite	29372 (ChEBI)
PDE2	GeneProduct	ENSG00000186642 (Ensembl)
PDE3	GeneProduct	ENSG00000172572 (Ensembl)
PKG2	GeneProduct	ENSG00000138669 (Ensembl)
TBH	Metabolite	64090 (ChEBI)
TNF-a	Protein	ENSG00000232810 (Ensembl)
TSPO	GeneProduct	ENSG00000100300 (Ensembl)
XIAP	GeneProduct	ENSG00000101966 (Ensembl)
cAMP	Metabolite	CHEBI:1325 (ChEBI)
cGMP	Metabolite	CHEBI:1327 (ChEBI)
eNOS	GeneProduct	ENSG00000164867 (Ensembl)
iNOS	GeneProduct	ENSG00000007171 (Ensembl)
nNOS	GeneProduct	ENSG00000089250 (Ensembl)

Annotated Interactions

No annotated interactions