Lidocaine metabolism (Bos taurus)

From WikiPathways

Revision as of 11:24, 30 June 2017 by DeSl (Talk | contribs)
Jump to: navigation, search
2, 31-33-hydroxymonoethylglycinexylidide4-hydroxy-2,6-dimethylanilineLidocaine3-hydroxylidocaine2,6-xylidineglycinexylididemonoethylglycinexylidideCYP3A42-amino-3-methylbenzoateCYP1A2CYP1A2CYP3A4


Description

Lidocaine is primarily metabolized by CYP1A2 but minor involvement of CYP3A4 is observed too. Lidocaine, also known as xylocaine and lignocaine is a medication used to numb tissue in a specific area.

Comments

 
Based on KEGG pathway http://www.genome.jp/kegg-bin/show_pathway?hsa00982.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2646(74430) with a 100.0% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P; ''Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.''; Clin Pharmacol Ther, 2004 PubMed Europe PMC Scholia
  2. Isohanni MH, Neuvonen PJ, Olkkola KT; ''Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.''; Basic Clin Pharmacol Toxicol, 2006 PubMed Europe PMC Scholia
  3. Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT; ''Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.''; Pharmacol Toxicol, 1999 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106002view11:52, 16 August 2019MaintBotHMDB identifier normalization
92725view11:41, 30 June 2017DeSlOntology Term : 'xenobiotic metabolic pathway' added !
92724view11:40, 30 June 2017DeSlOntology Term : 'drug pathway' added !
92722view11:24, 30 June 2017DeSlOntology Term : 'lidocaine drug pathway' added !
92721view11:22, 30 June 2017DeSlModified description
80892view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2,6-xylidineMetaboliteCHEBI:28738 (ChEBI)
2-amino-3-methylbenzoateMetabolite4161142 (PubChem-compound)
3-hydroxylidocaineMetabolite161824 (PubChem-compound)
3-hydroxymonoethyl glycinexylidideMetaboliteC16572 (KEGG Compound)
4-hydroxy- 2,6-dimethylanilineMetaboliteCHEBI:55545 (ChEBI)
CYP1A2GeneProductENSBTAG00000000085 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
LidocaineMetaboliteHMDB14426 (HMDB)
glycinexylidideMetaboliteCHEBI:357241 (ChEBI)
monoethyl glycinexylidideMetabolite24415 (PubChem-compound)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3254"
Personal tools