Pyrimidine metabolism (Homo sapiens)

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Alanine, aspartate and glutamate metabolismArginine and proline metabolismPentose phosphate pathwaybeta-Alanine metabolismTK2dTMPCDPTYMPUMPSCMPK1TYMS3-UreidopropionateDCTPP1CytidineUPB1Orotidine 5'-phosphatedUMPUPP2CADRRM2dUDPDPYSENPP1DUTENTPD8DPYDCDAbeta-AlanineCADdUTPCMPCADdCDPDCTDDHODHENTPD4UDPDeoxyuridineOrotateUDPThymidineNT5CCTPdCTPL-GlutamineRNADihydroorotateDNA5,6-DihydrouracilThymineUMPSCytosineUMPUracildCMPdTDPUPRT3.2.2.8N-Carbamoylaspartate2.4.2.2PNPT1UridineCarbamoylphosphateCTPS1UTPDeoxycytidineDTYMKdTTPDTYMK5-Phospho-alpha-D-ribose 1-diphosphateRRM1UCK1UCK2NT5CCDANT5CNT5CNT5CTK1TK2TK1CMPK2CMPK1CMPK2CMPK1CMPK2DCKENPP3RRM2BRRM2RRM1RRM2BENPP1ENPP3ENPP1ENPP3ENTPD3ENTPD1ENTPD8ENTPD3ENTPD1ENTPD8ENTPD3ENTPD1NME1-NME2NME1NME2NME3NME4NME6NME7NME1NMENMENMENMENMETYMPUPP1UPP2UPP1CTPS2UCKL1UCK1UCK2UCKL1NT5MNT5MNT5MNT5MNT5MZNRD1POLR1APRIM2POLA1POLR2APOLR2GPOLR2KPOLR3DPOLR3HPOLR1BPOLR1CPOLR1DPOLR1EPOLR2BPOLR2CPOLR2DPOLR2EPOLR2HPOLR2J1POLR2J2POLR2J3POLR2LPOLR3APOLR3BPOLR3CPOLR3EPOLR3FPOLR3GPOLR3GLPOLR3KPOLR2ITWISTNBRNA PolymeraseRNA PolymeraseRNA PolymeraseDNA PolymerasePOLD1POLD3POLE1POLE3PRIM1POLA2POLD2POLD4POLE2POLE43.2.2.10


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+map00240,
  2. Weissman SM; ''Human pyrimidine metabolism.''; JAMA, 1966 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137677view20:08, 6 March 2025KhanspersModified description
136149view08:16, 20 December 2024EgonwAdded a reference
126316view04:24, 21 April 2023EgonwLicense is CCZero
120306view15:13, 26 November 2021DeSlOntology Term : 'pyrimidine metabolic pathway' added !
120305view15:12, 26 November 2021DeSlOntology Term : 'PW:0000032' removed !
119398view10:52, 27 June 2021EweitzOntology Term : 'PW:0000032' removed !
119293view11:07, 23 June 2021Finterlyadded KEGG biopax information
106773view13:25, 17 September 2019MaintBotHMDB identifier normalization
106526view23:48, 5 September 2019Khanspersadded reference
106525view23:47, 5 September 2019KhanspersModified description
105797view22:48, 15 August 2019KhanspersModified description
95459view14:22, 15 December 2017DeSlChanged faulty ID for NME (3 more were present).
95458view14:20, 15 December 2017DeSlChanged faulty ID for NME.
95457view14:18, 15 December 2017DeSlchanged kegg ortholog to corresponding NCBI protein ID
94174view10:20, 25 August 2017DeSlConnected last interactions
94125view16:29, 22 August 2017DeSlAdded last changes for reaction arrows, connected RNA polymerase to PW.
94124view15:39, 22 August 2017DeSlAdded NT5E to several conversions, connected reverse reaction lines
94123view15:29, 22 August 2017DeSlConnected reverse reaction between dUTP and dUDP
94122view15:21, 22 August 2017DeSlConnected DNA-polymerase node
94121view15:06, 22 August 2017DeSlWorked on reverse reactions, added genes for conversion from dTTP to DNA
94120view14:57, 22 August 2017DeSlGrouped several proteins, connected lines, completed reverse reactions
94119view14:46, 22 August 2017DeSlAdded nodes to PW (on the right below)
94118view10:34, 22 August 2017DeSlFixed reverse reactions from orotate to orotidine 5'-phosphate
94117view10:10, 22 August 2017DeSlModified description
94116view10:09, 22 August 2017DeSlModified description
94115view10:07, 22 August 2017DeSlConnected lines, grouped enzymes, created PW nodes
94114view12:24, 21 August 2017DeSlModified description
94113view12:17, 21 August 2017DeSlModified description
94112view12:12, 21 August 2017DeSlOntology Term : 'pyrimidine metabolic pathway' added !
93049view12:00, 27 July 2017Annahoekstra1New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2.4.2.2GeneProductK00756 (Kegg ortholog)
3-UreidopropionateMetaboliteC02642 (KEGG Compound)
3.2.2.10GeneProductK10213 (Kegg ortholog)
3.2.2.8GeneProductK10213 (Kegg ortholog)
5,6-DihydrouracilMetaboliteC00429 (KEGG Compound)
5-Phospho-alpha-D-ribose 1-diphosphateMetaboliteC00119 (KEGG Compound)
CADGeneProduct790 (Entrez Gene) Original kegg element: gene;15;mtu:Rv1381
CDAGeneProduct978 (Entrez Gene) Original kegg element: gene;48;mtu:Rv3315c
CDPMetaboliteC00112 (KEGG Compound)
CMPMetaboliteHMDB00095 (HMDB)
CMPK1GeneProduct51727 (Entrez Gene) Original kegg element: gene;4;mtu:Rv2883c
CMPK2GeneProduct129607 (Entrez Gene) Original kegg element: gene;4;mtu:Rv2883c
CTPMetaboliteC00063 (KEGG Compound)
CTPS1GeneProduct1503 (Entrez Gene) Original kegg element: gene;25;mtu:Rv0321
CTPS2GeneProduct56474 (Entrez Gene) Original kegg element: gene;25;mtu:Rv0321
CarbamoylphosphateMetaboliteHMDB01096 (HMDB)
CytidineMetaboliteHMDB00089 (HMDB)
CytosineMetaboliteHMDB00630 (HMDB)
DCKGeneProduct1633 (Entrez Gene)
DCTDGeneProduct1635 (Entrez Gene)
DCTPP1GeneProduct79077 (Entrez Gene)
DHODHGeneProduct1723 (Entrez Gene) Original kegg element: gene;17;mtu:Rv2139
DNAMetaboliteC00039 (KEGG Compound)
DPYDGeneProduct1806 (Entrez Gene)
DPYSGeneProduct1807 (Entrez Gene)
DTYMKGeneProduct1841 (Entrez Gene) Original kegg element: gene;85;mtu:Rv3247c
DUTGeneProduct1854 (Entrez Gene) Original kegg element: gene;70;mtu:Rv2697c
DeoxycytidineMetaboliteC00881 (KEGG Compound)
DeoxyuridineMetaboliteHMDB00012 (HMDB)
DihydroorotateMetaboliteHMDB03349 (HMDB)
ENPP1GeneProduct5167 (Entrez Gene) Original kegg element: gene;26;mtu:Rv1699
ENPP3GeneProduct5169 (Entrez Gene) Original kegg element: gene;26;mtu:Rv1699
ENTPD1GeneProduct953 (Entrez Gene)
ENTPD3GeneProduct956 (Entrez Gene)
ENTPD4GeneProduct9583 (Entrez Gene) Original kegg element: gene;111;mtu:Rv1021
ENTPD8GeneProduct377841 (Kegg ortholog)
L-GlutamineMetaboliteHMDB00641 (HMDB)
N-CarbamoylaspartateMetaboliteHMDB00828 (HMDB)
NMEGeneProduct0 (Entrez Gene)
NME1-NME2GeneProduct654364 (Entrez Gene)
NME1GeneProduct4830 (Entrez Gene)
NME2GeneProduct4831 (Entrez Gene)
NME3GeneProduct4832 (Entrez Gene)
NME4GeneProduct4833 (Entrez Gene)
NME6GeneProduct10201 (Entrez Gene)
NME7GeneProduct29922 (Entrez Gene)
NT5CGeneProduct30833 (Entrez Gene)
NT5MGeneProduct56953 (Entrez Gene)
OrotateMetaboliteC00295 (KEGG Compound)
Orotidine 5'-phosphateMetaboliteC01103 (KEGG Compound)
PNPT1GeneProduct87178 (Entrez Gene) Original kegg element: gene;41;mtu:Rv2783c
POLA1GeneProduct5422 (Entrez Gene)
POLA2GeneProduct23649 (Entrez Gene)
POLD1GeneProduct5424 (Entrez Gene)
POLD2GeneProduct5425 (Entrez Gene)
POLD3GeneProduct10714 (Entrez Gene)
POLD4GeneProduct57804 (Entrez Gene)
POLE1GeneProduct5426 (Entrez Gene)
POLE2GeneProduct5427 (Entrez Gene)
POLE3GeneProduct54107 (Entrez Gene)
POLE4GeneProduct56655 (Entrez Gene)
POLR1AGeneProduct25885 (Entrez Gene)
POLR1BGeneProduct84172 (Entrez Gene)
POLR1CGeneProduct9533 (Entrez Gene)
POLR1DGeneProduct51082 (Entrez Gene)
POLR1EGeneProduct64425 (Entrez Gene)
POLR2AGeneProduct5430 (Entrez Gene)
POLR2BGeneProduct5431 (Entrez Gene)
POLR2CGeneProduct5432 (Entrez Gene)
POLR2DGeneProduct5433 (Entrez Gene)
POLR2EGeneProduct5434 (Entrez Gene)
POLR2GGeneProduct5436 (Entrez Gene)
POLR2HGeneProduct5437 (Entrez Gene)
POLR2IGeneProduct5438 (Entrez Gene)
POLR2J1GeneProduct5439 (Entrez Gene)
POLR2J2GeneProduct246721 (Entrez Gene)
POLR2J3GeneProduct548644 (Entrez Gene)
POLR2KGeneProduct5440 (Entrez Gene)
POLR2LGeneProduct5441 (Entrez Gene)
POLR3AGeneProduct11128 (Entrez Gene)
POLR3BGeneProduct55703 (Entrez Gene)
POLR3CGeneProduct10623 (Entrez Gene)
POLR3DGeneProduct661 (Entrez Gene)
POLR3EGeneProduct55718 (Entrez Gene)
POLR3FGeneProduct10621 (Entrez Gene)
POLR3GGeneProduct10622 (Entrez Gene)
POLR3GLGeneProduct84265 (Entrez Gene)
POLR3HGeneProduct171568 (Entrez Gene)
POLR3KGeneProduct51728 (Entrez Gene)
PRIM1GeneProduct5557 (Entrez Gene)
PRIM2GeneProduct5558 (Entrez Gene)
RNAMetaboliteC00046 (KEGG Compound)
RRM1GeneProduct6240 (Entrez Gene) Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c
RRM2GeneProduct6241 (Entrez Gene) Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c
RRM2BGeneProduct50484 (Entrez Gene) Original kegg element: gene;60;mtu:Rv0233 mtu:Rv0570 mtu:Rv1981c mtu:Rv3048c mtu:Rv3051c
TK1GeneProduct7083 (Entrez Gene)
TK2GeneProduct7084 (Entrez Gene)
TWISTNBGeneProduct221830 (Entrez Gene)
TYMPGeneProduct1890 (Entrez Gene)
TYMSGeneProduct7298 (Entrez Gene) Original kegg element: gene;6;mtu:Rv2754c
ThymidineMetaboliteHMDB00273 (HMDB)
ThymineMetaboliteHMDB00262 (HMDB)
UCK1GeneProduct83549 (Entrez Gene)
UCK2GeneProduct7371 (Entrez Gene)
UCKL1GeneProduct54963 (Entrez Gene)
UDPMetaboliteC00015 (KEGG Compound)
UMPMetaboliteHMDB00288 (HMDB)
UMPSGeneProduct7372 (Entrez Gene) Original kegg element: gene;106;mtu:Rv1385
UPB1GeneProduct51733 (Entrez Gene)
UPP1GeneProduct7378 (Entrez Gene)
UPP2GeneProduct151531 (Enzyme Nomenclature)
UPRTGeneProduct139596 (Entrez Gene)
UTPMetaboliteC00075 (KEGG Compound)
UracilMetaboliteHMDB00300 (HMDB)
UridineMetaboliteHMDB00296 (HMDB)
ZNRD1GeneProduct30834 (Entrez Gene)
beta-AlanineMetaboliteHMDB00056 (HMDB)
dCDPMetaboliteC00705 (KEGG Compound)
dCMPMetaboliteC00239 (KEGG Compound)
dCTPMetaboliteC00458 (KEGG Compound)
dTDPMetaboliteC00363 (KEGG Compound)
dTMPMetaboliteC00364 (KEGG Compound)
dTTPMetaboliteC00459 (KEGG Compound)
dUDPMetaboliteC01346 (KEGG Compound)
dUMPMetaboliteC00365 (KEGG Compound)
dUTPMetaboliteC00460 (KEGG Compound)

Annotated Interactions

No annotated interactions

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