PPAR signaling (Homo sapiens)

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1KetogenesisCYP27A1CYP7A1SLC27A4ACSL6cytochrome P450 4A14-likeSLC27A2FABP5CYP4A11RXRGNR1H3APOA2CYP4A11PPARDRXRAAPOA5SORBS1CPT1AHMGCS2GK3PDBIFatty acid metabolismGK2FABP4CYP4A11LPLAdipocytokine signaling pathwayAPOA1SLC27A4FABP6PCK1ME1ACSBG2ACSL1CYP4A11ACOX3PLTPFABP4PCK2ACSL3ACADLACAA1MMP1FABP7RXRACYP4A11unsaturated fatty acidsFABP3SCDACSL4PPARARXRARXRBRXRGSLC27A1OLR1CYP4A11ACADMSynthesis and degradation of ketone bodiesEHHADHRXRBPDPK1SCDPPARGAQP7MMP1CPT2ADIPOQACSBG1SLC27A6ACAA1FADS2SCP2ACSL5ILKRXRBRXRGUbcFABP3Primary bile acid biosynthesisPLIN1CYP4A11SCDSLC27A1CD36SLC27A5FABP1ACOX1CD36CYP4A11FABP1CPT1CCPT1BANGPTL4CYP8B1APOC3Glycerophospholipid metabolismSCDACOX2FABP2UCP1saturated fatty acidseicosanoidciprofibrateNSAIDs9-cis-Retinoic acidLipid transportLipogenesisCholesterol metabolismFatty acid transportFatty acid oxidationLipid metabolismAdipocyte differentiationAdaptive thermogenesisCell survivalGluconeogenesisUbiquitinationunsaturated fatty acids9-cis-Retinoic acidunsaturated fatty acidseicosanoidNSAIDsThiazolidine derivative9-cis-Retinoic acidLiverSkeletal muscleSkeletal muscleAdipocyteAdipocyte


Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Adapted from KEGG: http://www.genome.jp/kegg/pathway/mmu/mmu03320.html

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "PPAR signaling pathway", WP2316 revision 69143, with a 92.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129708view01:30, 22 May 2024EweitzModified title
106517view23:28, 5 September 2019KhanspersModified description
106205view12:10, 16 August 2019MaintBotHMDB identifier normalization
105777view19:42, 15 August 2019KhanspersModified description
104982view19:15, 27 June 2019KhanspersModified description
94205view21:11, 25 August 2017DeSlAdded ID for thiazolidine compound class from ChEBI.
91095view01:11, 4 January 2017Khanspersfixed unconnected interactions, updated missing xrefs, added lit ref
90815view18:40, 14 December 2016KhanspersOntology Term : 'cell of skeletal muscle' added !
90814view18:39, 14 December 2016KhanspersOntology Term : 'white fat cell' added !
90813view18:37, 14 December 2016KhanspersOntology Term : 'signaling pathway' added !
90812view18:36, 14 December 2016KhanspersOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
90811view18:36, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
9-cis-Retinoic acidMetaboliteHMDB02369 (HMDB)
ACAA1GeneProductENSG00000060971 (Ensembl)
  • Original kegg element: gene;21;mmu:113868 mmu:235674
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868
ACADLGeneProductENSG00000115361 (Ensembl)
  • Original kegg element: gene;23;mmu:11363
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363
ACADMGeneProductENSG00000117054 (Ensembl)
  • Original kegg element: gene;22;mmu:11364
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364
ACOX1GeneProductENSG00000161533 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACOX2GeneProductENSG00000168306 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
ACOX3GeneProductENSG00000087008 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
ACSBG1GeneProductENSG00000103740 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180
ACSBG2GeneProductENSG00000130377 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845
ACSL1GeneProductENSG00000151726 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
ACSL3GeneProductENSG00000123983 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
ACSL4GeneProductENSG00000068366 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
ACSL5GeneProductENSG00000197142 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256
ACSL6GeneProductENSG00000164398 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216739
ADIPOQGeneProductENSG00000181092 (Ensembl)
  • Original kegg element: gene;53;mmu:11450
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ANGPTL4GeneProductENSG00000167772 (Ensembl)
  • Original kegg element: gene;41;mmu:57875
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875
APOA1GeneProductENSG00000118137 (Ensembl)
  • Original kegg element: gene;61;mmu:11806
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806
APOA2GeneProductENSG00000158874 (Ensembl)
  • Original kegg element: gene;46;mmu:11807
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807
APOA5GeneProductENSG00000110243 (Ensembl)
  • Original kegg element: gene;64;mmu:66113
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113
APOC3GeneProductENSG00000110245 (Ensembl)
  • Original kegg element: gene;57;mmu:11814
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814
AQP7GeneProductENSG00000165269 (Ensembl)
  • Original kegg element: gene;7;mmu:11832
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832
Adipocytokine signaling pathwayGeneProductOriginal kegg element: map;34;path:mmu04920
CD36GeneProductENSG00000135218 (Ensembl)
  • Original kegg element: gene;11;mmu:12491
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491
CPT1AGeneProductENSG00000110090 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
CPT1BGeneProductENSG00000205560 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895
CPT1CGeneProductENSG00000169169 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070
CPT2GeneProductENSG00000157184 (Ensembl)
  • Original kegg element: gene;26;mmu:12896
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896
CYP27A1GeneProductENSG00000135929 (Ensembl)
  • Original kegg element: gene;60;mmu:104086
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086
CYP4A11GeneProductENSG00000187048 (Ensembl)
  • Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802
CYP7A1GeneProductENSG00000167910 (Ensembl)
  • Original kegg element: gene;33;mmu:13122
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122
CYP8B1GeneProductENSG00000180432 (Ensembl)
  • Original kegg element: gene;58;mmu:13124
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124
DBIGeneProductENSG00000155368 (Ensembl)
  • Original kegg element: gene;63;mmu:13167
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167
EHHADHGeneProductENSG00000113790 (Ensembl)
  • Original kegg element: gene;25;mmu:74147
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
FABP1GeneProductENSG00000163586 (Ensembl)
  • Original kegg element: gene;44;mmu:14080
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080
FABP2GeneProductENSG00000145384 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079
FABP3GeneProductENSG00000121769 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077
FABP4GeneProductENSG00000170323 (Ensembl)
  • Original kegg element: gene;40;mmu:11770
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770
FABP5GeneProductENSG00000164687 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16592
FABP6GeneProductENSG00000170231 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204
FABP7GeneProductENSG00000164434 (Ensembl)
  • Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140
FADS2GeneProductENSG00000134824 (Ensembl)
  • Original kegg element: gene;56;mmu:56473
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
Fatty acid metabolismGeneProductOriginal kegg element: map;35;path:mmu00071
GK2GeneProductENSG00000196475 (Ensembl)
  • Original kegg element: gene;8;mmu:14626 mmu:14933
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626
GK3PGeneProductENSG00000229894 (Ensembl)
  • Original kegg element: gene;8;mmu:14626 mmu:14933
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933
Glycerophospholipid metabolismGeneProductOriginal kegg element: map;52;path:mmu00564
HMGCS2GeneProductENSG00000134240 (Ensembl)
  • Original kegg element: gene;37;mmu:15360
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360
ILKGeneProductENSG00000166333 (Ensembl)
  • Original kegg element: gene;43;mmu:16202
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202
LPLGeneProductENSG00000175445 (Ensembl)
  • Original kegg element: gene;30;mmu:16956
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956
ME1GeneProductENSG00000065833 (Ensembl)
  • Original kegg element: gene;65;mmu:17436
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436
MMP1GeneProductENSG00000196611 (Ensembl)
  • Original kegg element: gene;39;mmu:83995 mmu:83996
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995
NR1H3GeneProductENSG00000025434 (Ensembl)
  • Original kegg element: gene;59;mmu:22259
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
OLR1GeneProductENSG00000173391 (Ensembl)
  • Original kegg element: gene;29;mmu:108078
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078
PCK1GeneProductENSG00000124253 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534
PCK2GeneProductENSG00000100889 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551
PDPK1GeneProductENSG00000140992 (Ensembl)
  • Original kegg element: gene;45;mmu:18607
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PLIN1GeneProductENSG00000166819 (Ensembl)
  • Original kegg element: gene;10;mmu:103968
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968
PLTPGeneProductENSG00000100979 (Ensembl)
  • Original kegg element: gene;47;mmu:18830
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830
PPARAGeneProductENSG00000186951 (Ensembl)
  • Original kegg element: gene;14;mmu:19013
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013
PPARDGeneProductENSG00000112033 (Ensembl)
  • Original kegg element: gene;16;mmu:19015
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015
PPARGGeneProductENSG00000132170 (Ensembl)
  • Original kegg element: gene;18;mmu:19016
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016
Primary bile acid biosynthesisGeneProductOriginal kegg element: map;51;path:mmu00120
RXRAGeneProductENSG00000186350 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
RXRBGeneProductENSG00000204231 (Ensembl)
  • Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
RXRGGeneProductENSG00000143171 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
SCDGeneProductENSG00000099194 (Ensembl)
  • Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249
SCP2GeneProductENSG00000116171 (Ensembl)
  • Original kegg element: gene;20;mmu:20280
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280
SLC27A1GeneProductENSG00000130304 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457
SLC27A2GeneProductENSG00000140284 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458
SLC27A4GeneProductENSG00000167114 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569
SLC27A5GeneProductENSG00000083807 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459
SLC27A6GeneProductENSG00000113396 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579
SORBS1GeneProductENSG00000095637 (Ensembl)
  • Original kegg element: gene;38;mmu:20411
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411
Synthesis and degradation of ketone bodiesGeneProductOriginal kegg element: map;50;path:mmu00072
Thiazolidine derivativeMetaboliteCHEBI:35622 (ChEBI)
UCP1GeneProductENSG00000109424 (Ensembl)
  • Original kegg element: gene;66;mmu:22227
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227
UbcGeneProduct
  • Original kegg element: gene;62;mmu:22190
  • No homologues found for original id L:22190
ciprofibrateMetaboliteCHEBI:50867 (ChEBI)
cytochrome P450 4A14-likeGeneProductOriginal kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
eicosanoidMetaboliteCHEBI:23899 (ChEBI)
saturated fatty acidsMetaboliteCHEBI:26607 (ChEBI)
unsaturated fatty acidsMetaboliteCHEBI:27208 (ChEBI)

Annotated Interactions

No annotated interactions
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