Heroin metabolism (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM; ''Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.''; Br J Pharmacol, 2010 PubMed Europe PMC Scholia
2. Maurer HH, Sauer C, Theobald DS; ''Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine.''; Ther Drug Monit, 2006 PubMed Europe PMC Scholia
3. Redinbo MR, Bencharit S, Potter PM; ''Human carboxylesterase 1: from drug metabolism to drug discovery.''; Biochem Soc Trans, 2003 PubMed Europe PMC Scholia
4. Sawynok J; ''The therapeutic use of heroin: a review of the pharmacological literature.''; Can J Physiol Pharmacol, 1986 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	123107	view	14:55, 3 July 2022	Egonw	Made a pathway clickable
	95179	view	15:51, 21 November 2017	DeSl	Ontology Term : 'heroin drug pathway' added !
	95178	view	15:50, 21 November 2017	DeSl	Modified description
	95177	view	15:49, 21 November 2017	DeSl	Added an enzyme+conversion, literature reference to support this and additional information.
	77113	view	09:35, 20 July 2014	Egonw	Less whitespace.
	77112	view	09:35, 20 July 2014	Egonw	The proper metabolization is in two steps. CES1 is involved in both.
	77111	view	09:30, 20 July 2014	Egonw	Found another reference that CES1 metabolizes heroin.
	77110	view	09:25, 20 July 2014	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
	77109	view	09:24, 20 July 2014	Egonw	Ontology Term : 'drug pathway' added !
	77108	view	09:23, 20 July 2014	Egonw	Modified description
	77107	view	09:22, 20 July 2014	Egonw	Found an article describing two enzymes that metabolize heroin.
	74321	view	15:33, 12 April 2014	Egonw	Added a missing metabolite identifier.
	74320	view	15:32, 12 April 2014	Egonw	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
6-acetylmorphine	Metabolite	5462507 (PubChem-compound)	6-monoacetylmorphine
CES1	GeneProduct	ENSG00000198848 (Ensembl)	catalyzed in liver
CES2	GeneProduct	ENSG00000172831 (Ensembl)	catalyzed in liver; catalytic efficiency is substantially greater for hCE-2 compared to other esterases.
Pseudo-ChE	Protein	ENSG00000114200 (Ensembl)	pseudocholinesterase
heroin	Metabolite	CHEBI:27808 (ChEBI)
morphine metabolism	Pathway	WP1604 (WikiPathways)
morphine	Metabolite	CHEBI:17303 (ChEBI)

Annotated Interactions

No annotated interactions