Purine metabolism (Homo sapiens)
From WikiPathways
Description
Overview of purine metabolism. Metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels.
This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version including disorders, based on ed. 4, can be found [here](https://www.wikipathways.org/index.php/Pathway:WP4224).
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP4792).Quality Tags
Ontology Terms
Saving...Bibliography
- Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
- Blau, N., Duran, M., Gibson, K.M., Dionisi-Vici, C.; ''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 11 and 41''; ISBN 978-3-642-40337-8, 2014
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2'-Deoxyadenosine | Metabolite | CHEBI:17256 (ChEBI)  | |
| 2'-deoxyinosine | Metabolite | CHEBI:28997 (ChEBI) | |
| 2,8-Dihydroxyadenine | Metabolite | Q4596812 (Wikidata) | |
| 2-Deoxyguanosine | Metabolite | CHEBI:17172 (ChEBI) | |
| ADA | Protein | P00813 (Uniprot-TrEMBL) | |
| ADP | Metabolite | CHEBI:456216 (ChEBI) | |
| ADSL | Protein | P30566 (Uniprot-TrEMBL) | |
| ADSS | Protein | P30520 (Uniprot-TrEMBL) | Adenylosuccinate synthetase isozyme 2 |
| AICA-riboside | Metabolite | CHEBI:28498 (ChEBI) | |
| AICARP | Metabolite | CHEBI:58475 (ChEBI) | |
| AMP | Metabolite | CHEBI:456215 (ChEBI) | |
| AMPD1 | Protein | P23109 (Uniprot-TrEMBL) | |
| APRT | Protein | P07741 (Uniprot-TrEMBL) | |
| ATIC | Protein | P31939 (Uniprot-TrEMBL) | |
| ATP | Metabolite | CHEBI:30616 (ChEBI) | |
| Adenine | Metabolite | CHEBI:16708 (ChEBI) | |
| Adenosine | Metabolite | CHEBI:16335 (ChEBI) | |
| DGUOK | Protein | Q16854 (Uniprot-TrEMBL) | |
| FAICARP | Metabolite | CHEBI:58467 (ChEBI) | |
| GDP | Metabolite | CHEBI:58189 (ChEBI) | |
| GMP | Metabolite | CHEBI:58115 (ChEBI) | |
| GTP | Metabolite | CHEBI:37565 (ChEBI) | |
| Guanine | Metabolite | CHEBI:16235 (ChEBI) | |
| Guanosine | Metabolite | CHEBI:16750 (ChEBI) | |
| HPRT1 | Protein | P00492 (Uniprot-TrEMBL) | |
| Hypoxanthine | Metabolite | CHEBI:17368 (ChEBI) | |
| IMP | Metabolite | CHEBI:58053 (ChEBI) | |
| IMPDH1 | Protein | P20839 (Uniprot-TrEMBL) | |
| ITPA | Protein | Q9BY32 (Uniprot-TrEMBL) | |
| ITP | Metabolite | CHEBI:61402 (ChEBI) | is a nucleoside triphosphate(4−) |
| Inosine | Metabolite | CHEBI:17596 (ChEBI) | |
| More detail:
Purine metabolism and related disorders | Pathway | WP4224 (WikiPathways) | |
| PNP | Protein | P00491 (Uniprot-TrEMBL) | |
| PRPP | Metabolite | CHEBI:17111 (ChEBI) | |
| PRPPs | Protein | 2.7.6.1 (Enzyme Nomenclature) | |
| PRPS1 | Protein | P60891 (Uniprot-TrEMBL) | |
| RR | Protein | 1.17.4.1 (Enzyme Nomenclature) | |
| Ribose-5-P | Metabolite | CHEBI:52742 (ChEBI) | |
| S-AMP | Metabolite | CHEBI:57567 (ChEBI) | succinyladenosine monophosphate |
| SAICA-riboside | Metabolite | CHEBI:18319 (ChEBI) | |
| SAICARP | Metabolite | CHEBI:58443 (ChEBI) | |
| Succinyladenosine | Metabolite | CHEBI:71169 (ChEBI) | |
| Urate | Metabolite | CHEBI:17775 (ChEBI) | |
| XMP | Metabolite | CHEBI:57464 (ChEBI) | |
| XO | Protein | P47989 (Uniprot-TrEMBL) | |
| Xanthine | Metabolite | CHEBI:17712 (ChEBI) | |
| Xanthosine | Metabolite | CHEBI:18107 (ChEBI) | |
| dADP | Metabolite | CHEBI:57667 (ChEBI) | |
| dAMP | Metabolite | CHEBI:58245 (ChEBI) | |
| dATP | Metabolite | CHEBI:61404 (ChEBI) | |
| dGDP | Metabolite | CHEBI:58595 (ChEBI) | |
| dGMP | Metabolite | CHEBI:57673 (ChEBI) | |
| dGTP | Metabolite | CHEBI:16497 (ChEBI) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| 2'-Deoxyadenosine | 2'-deoxyinosine | mim-conversion | 28191 (Rhea) | |
| 2'-Deoxyadenosine | Adenine | mim-conversion | 27743 (Rhea) | |
| 2'-deoxyinosine | Hypoxanthine | mim-conversion | 27751 (Rhea) | |
| 2-Deoxyguanosine | Guanine | mim-conversion | 27739 (Rhea) | |
| 2-Deoxyguanosine | dGMP | mim-conversion | 19202 (Rhea) | |
| ADP | ATP | mim-conversion | 30657 (Rhea) | |
| ADP | dADP | mim-conversion | 28036 (Rhea) | |
| AICARP | FAICARP | mim-conversion | 22193 (Rhea) | |
| AMP | ADP | mim-conversion | 11462 (Rhea) | |
| AMP | Adenosine | mim-conversion | 29376 (Rhea) | |
| AMP | IMP | mim-conversion | 14778 (Rhea) | |
| Adenine | AMP | mim-conversion | 16611 (Rhea) | |
| Adenosine | Adenine | mim-conversion | 18670 (Rhea) | |
| Adenosine | Inosine | mim-conversion | 24409 (Rhea) | |
| FAICARP | IMP | mim-conversion | 18447 (Rhea) | |
| GDP | GTP | mim-conversion | 29865 (Rhea) | |
| GDP | dGDP | mim-conversion | 28032 (Rhea) | |
| GMP | GDP | mim-conversion | 20781 (Rhea) | |
| GMP | Guanosine | mim-conversion | 27715 (Rhea) | |
| Guanine | mim-conversion | 14666 (Rhea) | ||
| Guanine | mim-conversion | 25426 (Rhea) | ||
| Guanosine | Guanine | mim-conversion | 13234 (Rhea) | |
| Hypoxanthine | Xanthine | mim-conversion | 24671 (Rhea) | |
| Hypoxanthine | mim-conversion | 17975 (Rhea) | ||
| IMP | Inosine | mim-conversion | 27719 (Rhea) | |
| IMP | S-AMP | mim-conversion | 15754 (Rhea) | |
| IMP | XMP | mim-conversion | 11709 (Rhea) | |
| ITP | IMP | mim-conversion | 29400 (Rhea) | |
| Inosine | Hypoxanthine | mim-conversion | 16658 (Rhea) | |
| S-AMP | AMP | mim-conversion | 16854 (Rhea) | |
| SAICARP | AICARP | mim-conversion | 23921 (Rhea) | |
| XMP | GMP | mim-conversion | 18302 (Rhea) | |
| XMP | Xanthosine | mim-conversion | 28531 (Rhea) | |
| Xanthine | Urate | mim-conversion | 16670 (Rhea) | |
| Xanthosine | Xanthine | mim-conversion | 27639 (Rhea) | |
| dADP | dAMP | mim-conversion | 23102 (Rhea) | |
| dADP | dATP | mim-conversion | 27675 (Rhea) | |
| dAMP | 2'-Deoxyadenosine | mim-conversion | 29372 (Rhea) | |
| dGDP | dGMP | mim-conversion | 12699 (Rhea) | |
| dGDP | dGTP | mim-conversion | 27691 (Rhea) | |
| dGMP | 2-Deoxyguanosine | mim-conversion | 19203 (Rhea) |
