Cell cycle (Homo sapiens)
From WikiPathways
Description
The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.
Sources: Wikipedia:Cell cycle, KEGG. Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia
- Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ABL1 | GeneProduct | ENSG00000097007 (Ensembl) | ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112 |
ANAPC10 | GeneProduct | ENSG00000164162 (Ensembl) | |
ANAPC11 | GeneProduct | ENSG00000141552 (Ensembl) | |
ANAPC13 | GeneProduct | ENSG00000129055 (Ensembl) | |
ANAPC1 | GeneProduct | ENSG00000153107 (Ensembl) | |
ANAPC2 | GeneProduct | ENSG00000176248 (Ensembl) | |
ANAPC4 | GeneProduct | ENSG00000053900 (Ensembl) | |
ANAPC5 | GeneProduct | ENSG00000089053 (Ensembl) | |
ANAPC7 | GeneProduct | ENSG00000196510 (Ensembl) | |
ATM | GeneProduct | ENSG00000149311 (Ensembl) | ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37] |
ATR | GeneProduct | ENSG00000175054 (Ensembl) | ATR; ataxia telangiectasia and Rad3 related |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BUB1 | GeneProduct | ENSG00000169679 (Ensembl) | BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-] |
BUB3 | GeneProduct | ENSG00000154473 (Ensembl) | MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast) |
CC14A | GeneProduct | ENSG00000079335 (Ensembl) | CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae |
CC14B | GeneProduct | ENSG00000081377 (Ensembl) | CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae |
CCNA1 | GeneProduct | ENSG00000133101 (Ensembl) | CCNA1; cyclin A1 |
CCNA2 | GeneProduct | ENSG00000145386 (Ensembl) | CCNA2; cyclin A2 |
CCNB1 | GeneProduct | ENSG00000134057 (Ensembl) | CCNB1; cyclin B1 |
CCNB2 | GeneProduct | ENSG00000157456 (Ensembl) | CCNB2; cyclin B2 |
CCNB3 | GeneProduct | ENSG00000147082 (Ensembl) | CCNB3; cyclin B |
CCND1 | GeneProduct | ENSG00000110092 (Ensembl) | CCND3; cyclin D3 |
CCND2 | GeneProduct | ENSG00000118971 (Ensembl) | CCND2; cyclin D2 |
CCND3 | GeneProduct | ENSG00000112576 (Ensembl) | CCND3; cyclin D3 |
CCNE1 | GeneProduct | ENSG00000105173 (Ensembl) | CCNE1; cyclin E |
CCNE2 | GeneProduct | ENSG00000175305 (Ensembl) | CCNE2; cyclin E |
CCNH | GeneProduct | ENSG00000134480 (Ensembl) | CCNH; cyclin H |
CDC16 | GeneProduct | ENSG00000130177 (Ensembl) | |
CDC20 | GeneProduct | 991 (Entrez Gene) | CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae |
CDC23 | GeneProduct | ENSG00000094880 (Ensembl) | |
CDC25A | GeneProduct | ENSG00000164045 (Ensembl) | PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37] |
CDC25B | GeneProduct | ENSG00000101224 (Ensembl) | CDC25C; cell division cycle 25C [EC:3.1.3.48] |
CDC25C | GeneProduct | ENSG00000158402 (Ensembl) | CDC25B; cell division cycle 25B [EC:3.1.3.48] |
CDC27 | GeneProduct | ENSG00000004897 (Ensembl) | |
CDC45 | GeneProduct | ENSG00000093009 (Ensembl) | CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae) |
CDC6 | GeneProduct | ENSG00000094804 (Ensembl) | CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae |
CDC7 | GeneProduct | ENSG00000097046 (Ensembl) | CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-] |
CDK1 | GeneProduct | ENSG00000170312 (Ensembl) | CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.- |
CDK2 | GeneProduct | ENSG00000123374 (Ensembl) | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-] |
CDK4 | GeneProduct | ENSG00000135446 (Ensembl) | CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-] |
CDK6 | GeneProduct | ENSG00000105810 (Ensembl) | CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-] |
CDK7 | GeneProduct | ENSG00000134058 (Ensembl) | CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-] |
CDKN1A | GeneProduct | ENSG00000124762 (Ensembl) | |
CDKN1B | GeneProduct | ENSG00000111276 (Ensembl) | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1) |
CDKN1C | GeneProduct | ENSG00000129757 (Ensembl) | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1) |
CDKN2A | GeneProduct | ENSG00000147889 (Ensembl) | |
CDKN2B | GeneProduct | ENSG00000147883 (Ensembl) | |
CDKN2C | GeneProduct | ENSG00000123080 (Ensembl) | |
CDKN2D | GeneProduct | ENSG00000129355 (Ensembl) | |
CHK1 | GeneProduct | 1111 (Entrez Gene) | CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-] |
CHK2 | GeneProduct | 11200 (Entrez Gene) | CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-] |
CUL1 | GeneProduct | ENSG00000055130 (Ensembl) | |
DBF4A | GeneProduct | ENSG00000006634 (Ensembl) | ASK; activator of S phase kinas |
DNA biosynthesis | Pathway | ||
E2F1 | GeneProduct | ENSG00000101412 (Ensembl) | E2F1; E2F transcription factor 1 |
E2F2 | GeneProduct | ENSG00000007968 (Ensembl) | E2F2; E2F transcription factor 2 |
E2F3 | GeneProduct | ENSG00000112242 (Ensembl) | E2F3; E2F transcription factor 3 |
E2F4 | GeneProduct | ENSG00000205250 (Ensembl) | E2F4; E2F transcription factor 4 p107/p130-binding |
E2F5 | GeneProduct | ENSG00000133740 (Ensembl) | E2F5; E2F transcription factor 5 p130-binding |
EP300 | GeneProduct | ENSG00000100393 (Ensembl) | EP300; E1A binding protein p300 |
ESPL1 | GeneProduct | ENSG00000135476 (Ensembl) | ESPL1; extra spindle poles like 1 (S. cerevisiae |
FZR1 | GeneProduct | ENSG00000105325 (Ensembl) | |
GADD45A | GeneProduct | ENSG00000116717 (Ensembl) | |
GADD45B | GeneProduct | ENSG00000099860 (Ensembl) | |
GADD45G | GeneProduct | ENSG00000130222 (Ensembl) | |
GSK3B | GeneProduct | ENSG00000082701 (Ensembl) | GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37] |
HDAC1 | GeneProduct | ENSG00000116478 (Ensembl) | HDAC1; histone deacetylase 1 |
HDAC2 | GeneProduct | ENSG00000196591 (Ensembl) | HDAC2; histone deacetylase 2 |
MAD1L1 | GeneProduct | ENSG00000002822 (Ensembl) | MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast |
MAD2L2 | GeneProduct | ENSG00000116670 (Ensembl) | MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast) |
MAPK signaling pathway | Pathway | WP382 (WikiPathways) | |
MCM2 | GeneProduct | ENSG00000073111 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
MCM3 | GeneProduct | ENSG00000112118 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
MCM4 | GeneProduct | ENSG00000104738 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
MCM5 | GeneProduct | ENSG00000100297 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
MCM6 | GeneProduct | ENSG00000076003 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
MCM7 | GeneProduct | ENSG00000166508 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
MD1L1 | GeneProduct | ENSG00000002822 (Ensembl) | MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast |
MDM2 | GeneProduct | ENSG00000135679 (Ensembl) | MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) |
MYC | GeneProduct | ENSG00000136997 (Ensembl) | |
ORC1 | GeneProduct | ENSG00000085840 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
ORC2 | GeneProduct | ENSG00000115942 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
ORC3 | GeneProduct | ENSG00000135336 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
ORC4 | GeneProduct | ENSG00000115947 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
ORC5 | GeneProduct | ENSG00000164815 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
ORC6 | GeneProduct | ENSG00000091651 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
PCNA | GeneProduct | ENSG00000132646 (Ensembl) | PCNA; proliferating cell nuclear antigen |
PKMYT1 | GeneProduct | ENSG00000127564 (Ensembl) | PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas |
PLK1 | GeneProduct | ENSG00000166851 (Ensembl) | PLK; polo-like kinase (Drosophila) [EC:2.7.1.-] |
PRKDC | GeneProduct | ENSG00000253729 (Ensembl) | PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37] |
PTTG1 | GeneProduct | ENSG00000164611 (Ensembl) | PTTG1; pituitary tumor-transforming |
PTTG2 | GeneProduct | ENSG00000250254 (Ensembl) | PTTG2; pituitary tumor-transforming |
RAD21 | GeneProduct | ENSG00000164754 (Ensembl) | ESPL1; extra spindle poles like 1 (S. cerevisiae |
RB1 | GeneProduct | ENSG00000139687 (Ensembl) | |
RBL1 | GeneProduct | ENSG00000080839 (Ensembl) | |
RBL2 | GeneProduct | ENSG00000103479 (Ensembl) | RB1; retinoblastoma 1 (including osteosarcoma) |
RBX1 | GeneProduct | ENSG00000100387 (Ensembl) | |
SFN | GeneProduct | ENSG00000175793 (Ensembl) | YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid |
SKP1 | GeneProduct | ENSG00000113558 (Ensembl) | |
SKP2 | GeneProduct | ENSG00000105810 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
SKP2 | GeneProduct | ENSG00000145604 (Ensembl) | SKP2; S-phase kinase-associated protein 2 (p45 |
SMAD2 | GeneProduct | ENSG00000175387 (Ensembl) | MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila) |
SMAD3 | GeneProduct | ENSG00000166949 (Ensembl) | MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila) |
SMAD4 | GeneProduct | ENSG00000141646 (Ensembl) | MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila) |
SMC1A | GeneProduct | ENSG00000072501 (Ensembl) | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast |
SMC1B | GeneProduct | ENSG00000077935 (Ensembl) | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast |
SMC3 | GeneProduct | ENSG00000108055 (Ensembl) | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast |
STAG1 | GeneProduct | ENSG00000118007 (Ensembl) | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast |
STAG2 | GeneProduct | ENSG00000101972 (Ensembl) | SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast |
TFDP1 | GeneProduct | ENSG00000198176 (Ensembl) | TFDP1; transcription factor Dp-1 |
TFDP2 | GeneProduct | ENSG00000114126 (Ensembl) | TFDP1; transcription factor Dp-1 |
TGFB1 | GeneProduct | ENSG00000105329 (Ensembl) | |
TGFB2 | GeneProduct | ENSG00000092969 (Ensembl) | |
TGFB3 | GeneProduct | ENSG00000119699 (Ensembl) | |
TP53 | GeneProduct | ENSG00000141510 (Ensembl) | |
TTK | GeneProduct | ENSG00000112742 (Ensembl) | BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-] |
Ubiquitin-mediated proteolysis | Pathway | WP183 (WikiPathways) | |
WEE1 | GeneProduct | ENSG00000166483 (Ensembl) | WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112] |
WEE2 | GeneProduct | ENSG00000214102 (Ensembl) | WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112] |
YWHAB | GeneProduct | 7529 (Entrez Gene) | |
YWHAE | GeneProduct | 7531 (Entrez Gene) | |
YWHAG | GeneProduct | 7532 (Entrez Gene) | |
YWHAH | GeneProduct | 7533 (Entrez Gene) | |
YWHAQ | GeneProduct | 10971 (Entrez Gene) | |
YWHAZ | GeneProduct | 7534 (Entrez Gene) | |
ZBTB17 | GeneProduct | ENSG00000116809 (Ensembl) |
Annotated Interactions
No annotated interactions