Aflatoxin B1 metabolism (Homo sapiens)
From WikiPathways
Description
Aflatoxins are naturally occurring mycotoxins that are produced by many species of Aspergillus, a fungus, most notably Aspergillus flavus and Aspergillus parasiticus. After entering the body, aflatoxins are metabolized by the liver to a reactive intermediate, aflatoxin M1, an epoxide. Aflatoxin B1 is considered the most toxic and is produced by both Aspergillus flavus and Aspergillus parasiticus.
Source: Wikipedia
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
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- Barski OA, Tipparaju SM, Bhatnagar A; ''The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.''; Drug Metab Rev, 2008 PubMed Europe PMC Scholia
- Kensler TW, Qian GS, Chen JG, Groopman JD; ''Translational strategies for cancer prevention in liver.''; Nat Rev Cancer, 2003 PubMed Europe PMC Scholia
- Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM; ''Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.''; Chem Res Toxicol, 2001 PubMed Europe PMC Scholia
- Guengerich FP, Arneson KO, Williams KM, Deng Z, Harris TM; ''Reaction of aflatoxin B(1) oxidation products with lysine.''; Chem Res Toxicol, 2002 PubMed Europe PMC Scholia
- Tiemersma EW, Omer RE, Bunschoten A, van't Veer P, Kok FJ, Idris MO, Kadaru AM, Fedail SS, Kampman E; ''Role of genetic polymorphism of glutathione-S-transferase T1 and microsomal epoxide hydrolase in aflatoxin-associated hepatocellular carcinoma.''; Cancer Epidemiol Biomarkers Prev, 2001 PubMed Europe PMC Scholia
- Stewart RK, Smith GB, Donnelly PJ, Reid KR, Petsikas D, Conlan AA, Massey TE; ''Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B(1) in human lung: differential cellular distribution and lack of significance of the GSTM1 genetic polymorphism.''; Carcinogenesis, 1999 PubMed Europe PMC Scholia
- Zhu LR, Thomas PE, Lu G, Reuhl KR, Yang GY, Wang LD, Wang SL, Yang CS, He XY, Hong JY; ''CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody.''; Drug Metab Dispos, 2006 PubMed Europe PMC Scholia
- He XY, Tang L, Wang SL, Cai QS, Wang JS, Hong JY; ''Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract.''; Int J Cancer, 2006 PubMed Europe PMC Scholia
- Jin Y, Penning TM; ''Aldo-keto reductases and bioactivation/detoxication.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
- Guengerich FP; ''Cytochrome P450s and other enzymes in drug metabolism and toxicity.''; AAPS J, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKR7A2 | GeneProduct | ENSG00000053371 (Ensembl) | |
AKR7A3 | GeneProduct | ENSG00000162482 (Ensembl) | |
Aflatoxin B1 8,9-dihydrodiol | Metabolite | CHEBI:53106 (ChEBI) | |
Aflatoxin B1 C6-monoalcohol | Metabolite | ||
Aflatoxin B1 C6-monoaldehyde | Metabolite | ||
Aflatoxin B1 C8-monoalcohol | Metabolite | ||
Aflatoxin B1 C8-monoaldehyde | Metabolite | ||
Aflatoxin B1 dialdehyde | Metabolite | CHEBI:53107 (ChEBI) | |
Aflatoxin B1 exo-8,9-epoxide-GSH | Metabolite | 5486953 (PubChem-compound) | |
Aflatoxin B1 exo-8,9-epoxide | Metabolite | HMDB0006558 (HMDB) | |
Aflatoxin B1-6,8-dialcohol | Metabolite | ||
Aflatoxin M1 epoxide | Metabolite | ||
Aflatoxin M1 | Metabolite | 15558498 (PubChem-compound) | |
Aflatoxin Q1 | Metabolite | 104757 (PubChem-compound) | |
Aflatoxin-endo-B1-8,9-epoxide | Metabolite | ||
CYP1A2 | GeneProduct | ENSG00000140505 (Ensembl) | |
CYP2A13 | GeneProduct | ENSG00000197838 (Ensembl) | |
CYP3A4 | GeneProduct | ENSG00000160868 (Ensembl) | |
EPHX1 | GeneProduct | ENSG00000143819 (Ensembl) | |
GSTM1 | GeneProduct | ENSG00000134184 (Ensembl) | |
GSTT1 | GeneProduct | ENSG00000277656 (Ensembl) | |
aflatoxin B1 | Metabolite | HMDB0006552 (HMDB) |
Annotated Interactions
No annotated interactions