AXL signaling pathway (Homo sapiens)

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PLASMA MEMBRANEANXA2MYCZEB1BECN1CASP1TGFBR2CCND1ATG5LEF1MAP1LC3BAXIN2FN1NLRP32439MSNTGF4GLI2CALD1TGFB2TMEM132ASMOADAM11GLI3NRG1TGFB1I1SPARCBMP8BAKT3SNAI3MITFAHNAK2VAV1P6BMP6EGFRBMP7Y1173Y11012, 19CDK434SP1CAV236CDK634CD274MYC CXCL16TGFB1LINC00526TMEFF1CXCR6BMP8AGLI1LYNBCL2 RPS6KA1T359S36349FOXP3BIRC5TGFB2COL3A1CHEK149LIGHTTFTGFBR2TP53CCR2YESDKK3SERPINE1CCL2ADGRE1VIMAXLY860Y815Y7799, 38, 44SOCS1ACOX1NFKB1A28MKI67CTLA4GSK3B S918, 22, 47, 52STAT138PBCL2L1TGFB1MAPK840, 42, 46PRPS6S263S9S2538, 12MMP9CCND1CPT1AATF2P40TNFANGPT2CASP34CTNNB1S552CD36CCNE1 MEK1SOCS3MERTKP33CDKN2AVCAM-1PI3K5, 7, 23PMAP2K215, 30MAP2K130MAPK3T20212, 32, 45MAPK1439PBcl-2MTOR37PTWISTKDR17IRS-1VEGFA17SNAI1ACTA2CTNNB1JUN40PPDK1LTBCAV1TNS248Y483CHUK20, 27PBIRC5MAPK9P40, 46TIMP1AKT1T30825, 33, 51S473SLUGcell migration and invasionPARP1MAPK143, 49, 50Y204MET11ACTA1FOXO13PIL1BFOXO1RPS6KB1GAS631PTK2P1COL1A1PAK1P29SNAI2SCDELMO19NFKB1A27PCDKN1APTPN11P17SNAILMCP1COL1A1CYR61 KRASAutophagyPPARGCPNUAnti-apoptotic Signaling Cell migrationTumor progressionEMTMMP2Tumor invasion/migrationAngiogenesisThrombosisCellular senescenceRegulatory T cells(Tregs)Lung adenocarcinomasCHEK149S280MDM434S314MDM2MDM4DAPKS30816CIP2A16ProliferationPMEGFR nuclear translocation mediatorsDormacy cellsurvivalApoptosisCYTOPLASMNUCLEUSCDH1Cell survivalRELA33RELA4, 10S529Colorectal CancerTranscription factorsTranscriptional regulator Bone morphogenetic proteinsChemokinesTransmembrane proteinCollagen Osteosarcoma Matrix metalloproteasesRAC53SRCY41621, 26, 41SMAD346S213Liver Inflammation, Steatohepatitis, and FibrosisIL1BIL-18InflammationCTNNB113EGFRPRKACACPNUFASFLT1COL3A1LEGENDLigandReceptorLeads to unknown mechanismPositive regulation of gene expressionNegative regulation of gene expressionTranslocationInhibitionPlasma membraneCytoplasmNucleusPMCPNUInduced CatalysisS100A10 SOCS3SOCS1 Immune suppressionActivationProteinProtein-Protein InteractionProteinmRNAACTA2STAT314, 35


Description

Axl is a transmembrane protein comes under TAM (Tyro3,Axl and Mertk) family of receptor tyrosine kinase (RTK). It is first identified as transforming gene, isolated from primary human myeloid leukemia cells. Axl gene is located in chromosome 19, at 19q13.1 , which encodes 894 amino acids with molecular weight range between 100 and 140kDa. Axl receptor is having extracellular, transmembrane and an intracellular domain. Extra cellular domain contains two immunoglobulin like (IgL) and fibronectin type-III (FN III) like domain with a single pass transmembrane domain.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
129211view01:33, 16 March 2024EweitzOntology Term : 'colorectal cancer' added !
129210view01:33, 16 March 2024EweitzOntology Term : 'osteosarcoma' added !
129209view01:32, 16 March 2024EweitzOntology Term : 'regulatory T cell' added !
129208view01:30, 16 March 2024EweitzFix typo
126496view21:59, 9 May 2023AlexanderPicoremoved "Other" datanode xrefs
126493view19:56, 9 May 2023Khanspersmore datanode identifiers
126492view19:43, 9 May 2023Khanspersremoved labels as datanode identifier
126491view19:27, 9 May 2023KhanspersReverted to version '23:56, 2 May 2023' by Khanspers
126490view19:26, 9 May 2023Khanspersconnected interactions
126473view23:56, 2 May 2023Khanspersremoved "activation" from legend. This should be indicated with interactions and not as a node color. Or added as a structured comment for the phosphosite.
126472view23:53, 2 May 2023Khanspersremoved unnecessary comments
126471view23:52, 2 May 2023Khanspersadded xrefs
126470view23:45, 2 May 2023Khanspersremoved colors, changed labels to label type, connected interactions
123895view11:28, 25 August 2022Finterlyfixed special shape
115887view16:19, 19 March 2021Keshav
115876view06:03, 19 March 2021Keshav
115875view05:58, 19 March 2021KeshavPathway update
111812view18:27, 8 September 2020EgonwRemoved a space in a PubMed identifier.
111809view16:01, 8 September 2020EgonwRemoved semicolons from the PubMed identifiers
111785view14:01, 7 September 2020DeSlRemoved special characters in publication list.
111784view13:52, 7 September 2020DeSlUpdated PMID ID (removed semicolon).
111783view13:51, 7 September 2020DeSlUpdated SRC protein ID
111515view05:07, 24 August 2020Rex D A Bupdate
111146view06:44, 20 July 2020Rex D A Blegend updated
111142view03:27, 19 July 2020Rex D A B
111141view03:25, 19 July 2020Rex D A BConnections
111140view13:18, 18 July 2020KeshavModified description
111138view11:14, 17 July 2020Rex D A BConnections and protein name
109999view19:17, 11 April 2020KeshavOntology Term : 'Gas6 - Axl signaling axis' added !
109998view19:11, 11 April 2020Keshavinteractions
109917view16:59, 6 April 2020KhanspersOntology Term : 'signaling pathway' added !
109422view07:26, 17 March 2020KeshavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Matrix metalloproteases
Immune suppression
RPS6KA1ProteinNP_002944.2 (NCBI Protein)
ACOX1GeneProduct51 (Entrez Gene)
ACTA1GeneProduct58 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
ADAM11GeneProduct4185 (Entrez Gene)
ADGRE1GeneProductADGRE1
AHNAK2GeneProduct113146 (Entrez Gene)
AKT1GeneProductAKT1 (Other)
AKT3GeneProduct10000 (Entrez Gene)
ANGPT2GeneProduct285 (Entrez Gene)
ANXA2GeneProductANXA2
ATF2ProteinNP_001871.2 (NCBI Protein)
ATG5GeneProduct9474 (Entrez Gene)
AXIN2GeneProductAXIN2
AXLProteinNP_068713.2 (NCBI Protein)
Angiogenesis
Anti-apoptotic Signaling
Apoptosis
Autophagy
BCL2GeneProduct596 (Entrez Gene)
BCL2L1GeneProduct596 (Entrez Gene)
BECN1GeneProduct8678 (Entrez Gene)
BIRC5GeneProductBIRC5
BMP6GeneProduct654 (Entrez Gene)
BMP7GeneProduct655 (Entrez Gene)
BMP8AGeneProduct353500 (Entrez Gene)
BMP8BGeneProduct656 (Entrez Gene)
Bcl-2GeneProductBcl-2
Bone morphogenetic proteins
CALD1GeneProduct800 (Entrez Gene)
CASP1GeneProductCASP1
CASP3GeneProduct836 (Entrez Gene)
CAV1GeneProduct857 (Entrez Gene)
CAV2GeneProduct858 (Entrez Gene)
CCL2GeneProduct6347 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND1GeneProductCCND1
CCNE1 GeneProductCCNE1
CCR2GeneProduct729230 (Entrez Gene)
CD274GeneProduct29126 (Entrez Gene)
CD36GeneProduct948 (Entrez Gene)
CDH1GeneProductCDH1
CDK4GeneProduct1019 (Entrez Gene)
CDK6GeneProduct1021 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CHEK1Protein1111 (Entrez Gene)
CHEK1ProteinCHEK1 (NCBI Protein)
CHUKProteinNP_001269.3 (NCBI Protein)
CIP2AGeneProduct57650 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
CP
CPT1AGeneProduct1374 (Entrez Gene)
CTLA4GeneProduct12477 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNB1GeneProductCTNNB1
CXCL16GeneProduct58191 (Entrez Gene)
CXCR6GeneProduct10663 (Entrez Gene)
CYR61 GeneProduct3491 (Entrez Gene)
Cell migration
Cell survival
Cellular senescence
Chemokines
Collagen
Colorectal Cancer
DAPKGeneProduct1612 (Entrez Gene)
DKK3GeneProduct27122 (Entrez Gene)
Dormacy cellsurvival
EGFR nuclear translocation mediators
EGFRGeneProductEGFR
EGFRGeneProductEGFR (Other)
ELMO1Protein9844 (Entrez Gene)
EMT
FASGeneProductFAS
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO1ProteinNP_002006.2 (NCBI Protein)
FOXP3GeneProduct50943 (Entrez Gene)
GAS6GeneProduct2621 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
GSK3B ProteinNP_002084.2 (NCBI Protein)
IL-18GeneProduct3606 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IRS-1GeneProduct3667 (Entrez Gene)
Inflammation
JUNProteinNP_002219.1 (NCBI Protein)
KDRProtein3791 (Entrez Gene)
KRASGeneProductKRAS
LEF1GeneProduct51176 (Entrez Gene)
LIGHTGeneProduct8740 (Entrez Gene)
LINC00526GeneProduct147525 (Entrez Gene)
LTBGeneProduct4050 (Entrez Gene)
LYNGeneProductLYN
Liver Inflammation, Steatohepatitis, and Fibrosis
Lung adenocarcinomas
MAP1LC3BGeneProduct81631 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAPK14ProteinNP_001306.1 (NCBI Protein)
MAPK1ProteinNP_002736.3 (NCBI Protein)
MAPK3ProteinNP_002737.2 (NCBI Protein)
MAPK8ProteinNP_001310259.1 (NCBI Protein)
MAPK9ProteinNP_002743.3 (NCBI Protein)
MCP1GeneProductMCP1
MDM2GeneProductMDM2
MDM4GeneProductMDM4
MDM4ProteinNP_002384.2 (NCBI Protein)
MEK1GeneProductMEK1
MERTKProtein10461 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MKI67GeneProductMKI67
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MSNGeneProduct4478 (Entrez Gene)
MTORProteinNP_004949.1 (NCBI Protein)
MYC GeneProduct4609 (Entrez Gene)
MYCGeneProductMYC
NFKB1AGeneProduct4790 (Entrez Gene)
NFKB1AProteinNP_065390.1 (NCBI Protein)
NLRP3GeneProduct114548 (Entrez Gene)
NRG1GeneProduct3084 (Entrez Gene)
NU
Osteosarcoma
PAK1ProteinNP_002567.3 (NCBI Protein)
PARP1GeneProduct142 (Entrez Gene)
PDK1GeneProductPDK1
PI3KProteinNP_006209.2 (NCBI Protein)
PM
PPARGGeneProduct5468 (Entrez Gene)
PRKACA5566 (Entrez Gene)
PTK2ProteinNP_001186578.1 (NCBI Protein)
PTPN11ProteinNP_002825.3 (NCBI Protein)
Proliferation
RACProteinNP_008839.2 (NCBI Protein)
RELAGeneProduct5970 (Entrez Gene)
RELAProteinNP_065390.1 (NCBI Protein)
RPS6KB1ProteinNP_003152.1 (NCBI Protein)
RPS6ProteinNP_001001.2 (NCBI Protein)
Regulatory T cells (Tregs)
S100A10 GeneProductS100A10
SCDGeneProduct6319 (Entrez Gene)
SERPINE1GeneProductSERPINE1
SLUGGeneProductSLUG
SMAD3ProteinNP_005893.1 (NCBI Protein)
SMOGeneProduct6608 (Entrez Gene)
SNAI1GeneProduct6615 (Entrez Gene)
SNAI2GeneProduct6591 (Entrez Gene)
SNAI3GeneProduct333929 (Entrez Gene)
SNAILGeneProductSNAIL
SOCS1GeneProduct8651 (Entrez Gene)
SOCS1GeneProductSOCS1
SOCS3GeneProduct9021 (Entrez Gene)
SOCS3GeneProductSOCS3
SP1GeneProduct28423548 (Entrez Gene)
SPARCGeneProduct6678 (Entrez Gene)
SRCProteinNP_005408.1 (NCBI Protein)
STAT1ProteinNP_009330.1 (NCBI Protein)
STAT3Protein6774 (Entrez Gene)
TFGeneProductTF
TGF4GeneProduct6925 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB1I1GeneProduct7041 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TMEFF1GeneProduct8577 (Entrez Gene)
TMEM132AGeneProduct54972 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TNS2ProteinNP_056134.2 (NCBI Protein)
TP53GeneProductTP53 (NCBI Protein)
TWISTGeneProduct7291 (Entrez Gene)
Thrombosis
Transcription factors
Transcriptional regulator
Transmembrane protein
Tumor invasion/migration
Tumor progression
VAV1ProteinNP_005419.2 (NCBI Protein)
VCAM-1GeneProduct7412 (Entrez Gene)
VEGFAProtein7422 (Entrez Gene)
VIMGeneProduct7431 (Entrez Gene)
YESGeneProductYES
ZEB1GeneProduct6935 (Entrez Gene)
cell migration and invasion

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4847"