Folate metabolism (Homo sapiens)
From WikiPathways
Description
The folic acid-centred micronutrient biological network. The most relevant biochemical processes related to folic acid in the context of metabolism, oxidation and inflammation are represented. Also, the compartmental separation (intracellular vs. plasma) is presented, identifying the folic acid centred plasma metabolome.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Pathway Ontology : pathway of folate cycle/metabolism
Bibliography
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History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
S-Adenosylhomocysteine | Metabolite | HMDB0000939 (HMDB) | |
S-Adenosylmethionine | Metabolite | HMDB0001185 (HMDB) | |
(11R)-hydroxymethylene-THF | Metabolite | (11R)-hydroxymethylenetetrahydrofolate | |
(11S)-hydroxymethylene-THF | Metabolite | (11S)-hydroxymethylenetetrahydrofolate | |
10-Formyl-THF | Metabolite | HMDB0000972 (HMDB) | 10-formyltetrahydrofolate |
5,10-Methenyl-THF | Metabolite | HMDB0001354 (HMDB) | 5,10-Methenyltetrahydrofolic acid |
5,10-Methylene-THF | Metabolite | HMDB0001533 (HMDB) | 5,10-Methylenetetrahydrofolate |
5-Formyl-THF | Metabolite | HMDB0001562 (HMDB) | 5-Formyltetrahydrofolate |
5-methyl-THF | Metabolite | HMDB0001396 (HMDB) |
|
8-Isoprostaglandin F2a | Metabolite | HMDB0005083 (HMDB) | |
8-OHdG | Metabolite | HMDB0003333 (HMDB) | 8-Hydroxy-deoxyguanosine |
ABCA1 | Protein | 19 (Entrez Gene) | ATP-binding cassette, sub-family A (ABC1), member 1 |
ACT | Protein | 12 (Entrez Gene) |
|
ADP | Metabolite | HMDB0001341 (HMDB) | Adenosine diphosphate |
AHCY | Protein | 191 (Entrez Gene) |
|
ALB | Protein | 213 (Entrez Gene) | albumin |
APOA1-NO2Tyr | Protein | 335 (Entrez Gene) | Nitrotyrosinated apolipoprotein A-I |
APOA1 | Protein | 335 (Entrez Gene) | apolipoprotein A-I |
APOB | Protein | 338 (Entrez Gene) | apolipoprotein B |
ATP | Metabolite | HMDB0000538 (HMDB) | Adenosine triphosphate |
CBS | Protein | 875 (Entrez Gene) |
|
CRP | Protein | 1401 (Entrez Gene) | C-reactive protein, pentraxin-related |
CSF1 | Protein | 1435 (Entrez Gene) | colony stimulating factor 1 (macrophage) |
CTH | Protein | 1491 (Entrez Gene) |
|
Catalase | Protein | 847 (Entrez Gene) | EC 1.11.1.6 |
Chlorine | Metabolite | HMDB0000492 (HMDB) | |
Cholesterol | Metabolite | HMDB0000067 (HMDB) | |
Cob(I)alamin | Metabolite | HMDB0002174 (HMDB) | Reduced cobalamin |
Cob(II)alamin | Metabolite | HMDB0002174 (HMDB) | oxidized cobalamin |
Cystathionine | Metabolite | HMDB0000099 (HMDB) | |
Cysteine | Metabolite | HMDB0000574 (HMDB) | |
D-dimer | Protein | Q2162109 (Wikidata) | http://en.wikipedia.org/wiki/Fibrin_degradation_product |
DHFR | Protein | 1719 (Entrez Gene) |
|
Dihydrofolate | Metabolite | HMDB0001056 (HMDB) | |
F2-Isoprostane | Metabolite | Q33659470 (Wikidata) | |
FAD | Metabolite | HMDB0001248 (HMDB) | Flavin adenine dinucleotide |
FGA | Protein | ENSG00000171560 (Ensembl) | |
FGAR | Metabolite | CHEBI:18272 (ChEBI) | formylglycinamide ribonucleotide |
FGB | Protein | ENSG00000171564 (Ensembl) | |
FGG | Protein | ENSG00000171557 (Ensembl) | |
FLAD1 | Protein | 80308 (Entrez Gene) |
|
FMN | Metabolite | HMDB0001520 (HMDB) | Flavin Mononucleotide |
FOLR1 | GeneProduct | 2348 (Entrez Gene) | folate receptor 1 (adult) |
FOLR2 | GeneProduct | 2350 (Entrez Gene) | folate receptor 2 (fetal) |
FOLR3 | GeneProduct | 2352 (Entrez Gene) | folate receptor 3 (gamma) |
FOLR4 | GeneProduct | 390243 (Entrez Gene) | folate receptor 4 (delta) homolog (mouse) |
Factor VII | Protein | 2155 (Entrez Gene) |
|
Fibrin | Metabolite | Q27205 (Wikidata) | |
Fibrinogen | Protein | Q381899 (Wikidata) | |
Folate | Metabolite | CHEBI:37445 (ChEBI) | Generic term used to denote both naturally occurring folate in foods (food folate) and the synthetic form of the vitamin (folic acid). |
Folic acid | Metabolite | HMDB0000121 (HMDB) | Synthetic folate |
Fructosamine | Metabolite | HMDB0002030 (HMDB) | |
GAR | Metabolite | HMDB0002022 (HMDB) | glycinamide ribonucleotide |
GART | Protein | 2618 (Entrez Gene) |
|
GPX 1 | Protein | 2876 (Entrez Gene) |
|
GPX 2 | Protein | 2877 (Entrez Gene) |
|
GPX 3 | Protein | 2878 (Entrez Gene) |
|
GPX 4 | Protein | 2879 (Entrez Gene) |
|
GPX 6 | Protein | 257202 (Entrez Gene) |
|
Glucose | Metabolite | HMDB0000122 (HMDB) | |
Glycine | Metabolite | HMDB0000123 (HMDB) | |
H2O2 | Metabolite | HMDB0003125 (HMDB) | Hydrogen peroxide |
H2O | Metabolite | HMDB0002111 (HMDB) | Glutathione disulfide |
HBA1 | Protein | 3039 (Entrez Gene) | hemoglobin, alpha 1 |
HBB | Protein | 3043 (Entrez Gene) | hemoglobin, beta |
HDL-C | Metabolite | CHEBI:47775 (ChEBI) |
|
HDL/APOA1 | Metabolite | CHEBI:39025 (ChEBI) |
|
HDL/SAA | Metabolite | CHEBI:39025 (ChEBI) |
|
HDL | Metabolite | CHEBI:39025 (ChEBI) | high-density lipoprotein |
HNO2 | Metabolite | CHEBI:25567 (ChEBI) | Nitrous acid |
HOCl | Metabolite | HMDB0001050 (HMDB) | Hypochlorite |
HbA1c | Protein |
| |
HbA1c | Protein | Q311213 (Wikidata) |
|
Heme | Metabolite | HMDB0003178 (HMDB) | |
Homocysteine | Metabolite | HMDB0000742 (HMDB) | |
IFNg | Protein | 3458 (Entrez Gene) | interferon, gamma |
IL10 | Protein | 3458 (Entrez Gene) | interferon, gamma |
IL1B | Protein | 3553 (Entrez Gene) | interleukin 1, beta |
IL2 | Protein | 3558 (Entrez Gene) | interleukin 2 |
IL4 | Protein | 3565 (Entrez Gene) | interleukin 4 |
IL6 | Protein | 3569 (Entrez Gene) | interleukin 6 (interferon, beta 2) |
INS | Protein | 3630 (Entrez Gene) | Insulin |
INSR | Protein | 3643 (Entrez Gene) | Insulin receptor |
Iron | Metabolite | HMDB0000692 (HMDB) | |
L-Arginine | Metabolite | HMDB0000517 (HMDB) | |
LDL | Metabolite | CHEBI:39026 (ChEBI) | low-density lipoprotein |
LDLR | Protein | 3949 (Entrez Gene) | low density lipoprotein receptor |
MAT | Protein | 4143 (Entrez Gene) |
|
MCP1 | GeneProduct | 6347 (Entrez Gene) |
|
MPO | Protein | 4353 (Entrez Gene) |
|
MSR* | Protein | 4552 (Entrez Gene) |
|
MTHFD1* | Protein | 4522 (Entrez Gene) |
|
MTHFD2 | Protein | 10797 (Entrez Gene) |
|
MTHFR* | Protein | 4524 (Entrez Gene) |
|
MTHFS | Protein | 10588 (Entrez Gene) |
|
MTR* | Protein | 4548 (Entrez Gene) |
|
Magnesium | Metabolite | HMDB0000547 (HMDB) | |
Manganese | Metabolite | HMDB0001333 (HMDB) | |
Methionine | Metabolite | HMDB0000696 (HMDB) | |
NADP+ | Metabolite | HMDB0000217 (HMDB) | Nicotinamide adenine dinucleotide phosphate-Oxidized |
NADPH | Metabolite | HMDB0000221 (HMDB) | Nicotinamide adenine dinucleotide phosphate-Reduced |
NFKB1 | GeneProduct | 4790 (Entrez Gene) | nuclear factor NF-kappa-B p50 subunit |
NFKB2 | GeneProduct | 4791 (Entrez Gene) | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 |
NO2 | Metabolite | CHEBI:33101 (ChEBI) | Nitrogen dioxide |
NO | Metabolite | HMDB0003378 (HMDB) | Nitric oxide |
NOS | Protein | C9J5P6 (Uniprot-TrEMBL) | Nitric oxide synthase |
Nitrotyrosine | Metabolite | HMDB0001904 (HMDB) | |
O2 | Metabolite | HMDB0001377 (HMDB) | |
O2 | Metabolite | HMDB0002168 (HMDB) | Superoxide |
O3 | Metabolite | CHEBI:25812 (ChEBI) | ozone |
ONOO/ONOOH | Metabolite | HMDB0002179 (HMDB) | Peroxynitrite |
PAI-1 | Protein | 5054 (Entrez Gene) | Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
PGE1 | Metabolite | HMDB0001442 (HMDB) | Prostaglandin E1 |
PGE2 | Metabolite | HMDB0001220 (HMDB) | Prostaglandin E2 |
PGF2a | Metabolite | HMDB0001139 (HMDB) | Prostaglandin F2a |
PLG | Protein | 5340 (Entrez Gene) |
|
Pyridoxal 5'-phosphate | Metabolite | HMDB0001491 (HMDB) | Vitamin B6 |
RELA | GeneProduct | 5970 (Entrez Gene) | nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 |
RFK | Protein | 55312 (Entrez Gene) |
|
RNS | Metabolite | CHEBI:62764 (ChEBI) |
|
Riboflavin | Metabolite | HMDB0000244 (HMDB) | |
S-nitrosohomocysteine | Metabolite | 3035701 (PubChem-compound) | |
SAA1 | Protein | 6288 (Entrez Gene) | serum amyloid A1 |
SAA2 | Protein | 6289 (Entrez Gene) | serum amyloid A2 |
SAA3 | Protein | 6290 (Entrez Gene) | serum amyloid A3 pseudogene |
SAA4 | Protein | 6291 (Entrez Gene) | serum amyloid A4, constitutive |
SHMT | Protein | 6470 (Entrez Gene) |
|
SHMT | Protein | 6472 (Entrez Gene) |
|
SLC19A1 | GeneProduct | 6573 (Entrez Gene) | solute carrier family 19 (folate transporter), member 1 |
SLC46A1 | GeneProduct | 113235 (Entrez Gene) | solute carrier family 46 (folate transporter), member 1 |
SOD1 | Protein | 6647 (Entrez Gene) |
|
SOD2 | Protein | 6648 (Entrez Gene) |
|
SOD3 | Protein | 6649 (Entrez Gene) |
|
SRB1 | Protein | 949 (Entrez Gene) | scavenger receptor class B, member 1 |
Serine | Metabolite | HMDB0000187 (HMDB) | |
TAG | Metabolite | CHEBI:17855 (ChEBI) |
|
THF | Metabolite | HMDB0001846 (HMDB) | Tetrahydrofolic acid |
TNFa | Protein | 7124 (Entrez Gene) | tumor necrosis factor (TNF superfamily, member 2) |
Tetrahydrobiopterin | Metabolite | HMDB0000027 (HMDB) | H4B |
Thrombin | Protein | 2147 (Entrez Gene) |
|
Thromboxane A2 | Metabolite | HMDB0001452 (HMDB) | |
Thromboxane B2 | Metabolite | HMDB0003252 (HMDB) | |
VLDL-TAG | Metabolite | CHEBI:47776 (ChEBI) |
|
VLDL/APOB | Metabolite | CHEBI:39027 (ChEBI) |
|
VLDL | Metabolite | CHEBI:39027 (ChEBI) | very-low-density lipoprotein |
Zinc | Metabolite | HMDB0015532 (HMDB) | |
oxLDL | Metabolite | CHEBI:60151 (ChEBI) | oxidized low-density lipoprotein |
p53 | GeneProduct | 7157 (Entrez Gene) | tumor protein p53 |
sICAM-1 | Protein | 3383 (Entrez Gene) | soluble intercellular adhesion molecule 1 |
tPA | Protein | 5327 (Entrez Gene) |
|
Annotated Interactions
No annotated interactions