Sulindac metabolic pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Sulindac-SSulfindac sulfideMsrAFMOMsrB2MsrB3CYP1B1CYP1A2Sulindac-RSulindac sulfoneCYP1A2Name: Sulindac metabolic pathwayOrganism: Homo sapiens


Description

Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117834
Approved
view15:10, 22 May 2021EweitzModified title
105115view13:43, 8 July 2019DeSlChanged ID for FMO from wikidata to interpro.
102205view14:56, 9 December 2018EgonwModified description
102204view14:55, 9 December 2018EgonwModified title
102203view14:54, 9 December 2018EgonwModified title
102202view14:54, 9 December 2018EgonwReplaced a Wikipedia with a Wikidata identifier.
97769view13:33, 7 June 2018MaxvansonModified description
92293view12:43, 19 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
88583view19:21, 11 August 2016Mkutmonfix unconnected lines
87597view08:13, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
70621view15:07, 16 August 2013EgonwHow did I manage to switch the R and S epimer??
70618view14:53, 16 August 2013EgonwHumanized the pathway: human Ensemble IDs.
70617view14:39, 16 August 2013EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
FMOGeneProductIPR000960 (InterPro)
MsrAGeneProductENSG00000175806 (Ensembl)
MsrB2GeneProductENSG00000148450 (Ensembl)
MsrB3GeneProductENSG00000174099 (Ensembl)
Sulfindac sulfideMetabolite4509492 (Chemspider)
Sulindac sulfoneMetabolite4582441 (Chemspider) The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-RMetabolite16046677 (PubChem-compound)
Sulindac-SMetabolite11245227 (PubChem-compound)

Annotated Interactions

No annotated interactions

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