Sulindac metabolic pathway (Homo sapiens)

Description

Metabolism of sulindac sulfide is catalyzed by MsrA, MsrB2, and MsrB3.

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Brunell D, Sagher D, Kesaraju S, Brot N, Weissbach H; ''Studies on the metabolism and biological activity of the epimers of sulindac.''; Drug Metab Dispos, 2011 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
117834	view	15:10, 22 May 2021	Eweitz	Modified title
105115	view	13:43, 8 July 2019	DeSl	Changed ID for FMO from wikidata to interpro.
102205	view	14:56, 9 December 2018	Egonw	Modified description
102204	view	14:55, 9 December 2018	Egonw	Modified title
102203	view	14:54, 9 December 2018	Egonw	Modified title
102202	view	14:54, 9 December 2018	Egonw	Replaced a Wikipedia with a Wikidata identifier.
97769	view	13:33, 7 June 2018	Maxvanson	Modified description
92293	view	12:43, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
88583	view	19:21, 11 August 2016	Mkutmon	fix unconnected lines
87597	view	08:13, 25 July 2016	MirellaKalafati	Ontology Term : 'classic metabolic pathway' added !
70621	view	15:07, 16 August 2013	Egonw	How did I manage to switch the R and S epimer??
70618	view	14:53, 16 August 2013	Egonw	Humanized the pathway: human Ensemble IDs.
70617	view	14:39, 16 August 2013	Egonw	New pathway

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Name	Type	Database reference	Comment
CYP1A2	GeneProduct	ENSG00000140505 (Ensembl)
CYP1B1	GeneProduct	ENSG00000138061 (Ensembl)
FMO	GeneProduct	IPR000960 (InterPro)
MsrA	GeneProduct	ENSG00000175806 (Ensembl)
MsrB2	GeneProduct	ENSG00000148450 (Ensembl)
MsrB3	GeneProduct	ENSG00000174099 (Ensembl)
Sulfindac sulfide	Metabolite	4509492 (Chemspider)
Sulindac sulfone	Metabolite	4582441 (Chemspider)	The structure for the sulfone in the paper is inconsistent with the entries in ChemSpider and PubChem; I assume the paper made typographic errors.
Sulindac-R	Metabolite	16046677 (PubChem-compound)
Sulindac-S	Metabolite	11245227 (PubChem-compound)

No annotated interactions