Heroin metabolism (Homo sapiens)

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Description

Pathway complementing the morphine metabolism pathway around heroin. The catalytic efficiency is substantially greater for CES2 (a.k.a. hCE-2) compared to other esterases.

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Ontology Terms

 

Bibliography

  1. Maurer HH, Sauer C, Theobald DS; ''Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine.''; Ther Drug Monit, 2006 PubMed Europe PMC Scholia
  2. Sawynok J; ''The therapeutic use of heroin: a review of the pharmacological literature.''; Can J Physiol Pharmacol, 1986 PubMed Europe PMC Scholia
  3. Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM; ''Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.''; Br J Pharmacol, 2010 PubMed Europe PMC Scholia
  4. Redinbo MR, Bencharit S, Potter PM; ''Human carboxylesterase 1: from drug metabolism to drug discovery.''; Biochem Soc Trans, 2003 PubMed Europe PMC Scholia
  5. Milella MS, D'Ottavio G, De Pirro S, Barra M, Caprioli D, Badiani A; ''Heroin and its metabolites: relevance to heroin use disorder.''; Transl Psychiatry, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
139960view10:21, 13 July 2025EgonwAdded a recent article with experimental data for this pathway
136249view17:18, 15 January 2025Khanspersspacing
123107view14:55, 3 July 2022EgonwMade a pathway clickable
95179view15:51, 21 November 2017DeSlOntology Term : 'heroin drug pathway' added !
95178view15:50, 21 November 2017DeSlModified description
95177view15:49, 21 November 2017DeSlAdded an enzyme+conversion, literature reference to support this and additional information.
77113view09:35, 20 July 2014EgonwLess whitespace.
77112view09:35, 20 July 2014EgonwThe proper metabolization is in two steps. CES1 is involved in both.
77111view09:30, 20 July 2014EgonwFound another reference that CES1 metabolizes heroin.
77110view09:25, 20 July 2014EgonwOntology Term : 'xenobiotic metabolic pathway' added !
77109view09:24, 20 July 2014EgonwOntology Term : 'drug pathway' added !
77108view09:23, 20 July 2014EgonwModified description
77107view09:22, 20 July 2014EgonwFound an article describing two enzymes that metabolize heroin.
74321view15:33, 12 April 2014EgonwAdded a missing metabolite identifier.
74320view15:32, 12 April 2014EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-acetylmorphineMetabolite5462507 (PubChem-compound) 6-monoacetylmorphine
CES1GeneProductENSG00000198848 (Ensembl) catalyzed in liver
CES2GeneProductENSG00000172831 (Ensembl) catalyzed in liver; catalytic efficiency is substantially greater for hCE-2 compared to other esterases.
Pseudo-ChEProteinENSG00000114200 (Ensembl) pseudocholinesterase
heroinMetaboliteCHEBI:27808 (ChEBI)
morphine metabolismPathwayWP1604 (WikiPathways)
morphineMetaboliteCHEBI:17303 (ChEBI)

Annotated Interactions

No annotated interactions

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