PPAR signaling (Homo sapiens)

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Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3942).

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Bibliography

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  1. Takada I, Kato S; ''[PPARs target genes].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  2. Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  3. Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  4. Desvergne B, Michalik L, Wahli W; ''Transcriptional regulation of metabolism.''; Physiol Rev, 2006 PubMed Europe PMC Scholia
  5. Inoue H; ''[Endogenous ligands for PPARs].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
  6. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; Prog Lipid Res, 2006 PubMed Europe PMC Scholia
  7. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  8. Desvergne B, Wahli W; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; Endocr Rev, 1999 PubMed Europe PMC Scholia
  9. Savage DB; ''PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.''; Expert Rev Mol Med, 2005 PubMed Europe PMC Scholia
  10. Semple RK, Chatterjee VK, O'Rahilly S; ''PPAR gamma and human metabolic disease.''; J Clin Invest, 2006 PubMed Europe PMC Scholia
  11. Lehrke M, Lazar MA; ''The many faces of PPARgamma.''; Cell, 2005 PubMed Europe PMC Scholia
  12. Hauner H; ''The mode of action of thiazolidinediones.''; Diabetes Metab Res Rev, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137952view20:52, 10 March 2025KhanspersModified description
136348view00:45, 27 January 2025EweitzOntology Term : 'CL:0000448' removed !
136347view00:36, 27 January 2025EweitzAdd references from source KEGG pathway (hsa03320)
136346view00:26, 27 January 2025EweitzOntology Term : 'hepatocyte' added !
136345view00:25, 27 January 2025EweitzOntology Term : 'PW:0001355' removed !
136344view00:25, 27 January 2025EweitzOntology Term : 'adipocyte' added !
136343view00:11, 27 January 2025EweitzRemove HomologyMapper comment and mouse metadata; revised to directly translate human KEGG pathway
136342view00:08, 27 January 2025EweitzAdd new pathway start: VLDL, chylomicron
136341view14:14, 26 January 2025EweitzRemove genes not in source KEGG pathway (presumably inferred through broad homology mapping)
136340view14:03, 26 January 2025EweitzRefine label size and alignment
136339view13:52, 26 January 2025EweitzRefine interactions at start
136338view13:47, 26 January 2025EweitzRefine terminal interactions
136337view05:10, 26 January 2025EweitzMitigate PathVisio discrepancy with Pvjs / Kaavio
136336view05:09, 26 January 2025EweitzAlign nodes
136335view05:08, 26 January 2025EweitzEconomize layout
136334view05:07, 26 January 2025EweitzEconomize layout, align nodes
136333view05:04, 26 January 2025EweitzAlign nodes
136332view05:03, 26 January 2025EweitzUpgrade to pathway nodes
136331view04:56, 26 January 2025EweitzAdd cell membrane, nucleus membrane
136330view04:43, 26 January 2025EweitzConvert PPAR complex lines from straight to elbow, for easier discernibility
136329view04:14, 26 January 2025EweitzRefine layout
136328view04:13, 26 January 2025EweitzEconomize layout
136327view04:08, 26 January 2025EweitzEconomize layout
136326view03:20, 26 January 2025EweitzClear cached board dimensions
136325view03:19, 26 January 2025EweitzRemove label uneditable in PathVisio, via https://classic.wikipathways.org/index.php?title=Pathway:WP3942&action=edit
136324view03:13, 26 January 2025EweitzEconomize layout
136323view03:10, 26 January 2025EweitzEconomize layout
136322view03:07, 26 January 2025EweitzEconomize layout
136321view02:56, 26 January 2025EweitzEconomize layout
136320view02:55, 26 January 2025EweitzRemove large empty graphical element
136319view02:54, 26 January 2025EweitzStandardize case
136318view02:52, 26 January 2025EweitzEconomize layout
136317view02:46, 26 January 2025EweitzEconomize layout
136316view02:41, 26 January 2025EweitzEconomize layout
136315view02:35, 26 January 2025EweitzEconomize layout
136314view02:22, 26 January 2025EweitzEconomize layout
136313view02:22, 26 January 2025EweitzEconomize layout
136312view01:59, 26 January 2025EweitzRemove duplicate genes, genes not in source
136311view01:14, 26 January 2025EweitzRemove genes not in source KEGG pathway
136310view22:20, 25 January 2025EweitzStandardize node size, font size, font family
136309view21:52, 25 January 2025EweitzEconomize layout
129708view01:30, 22 May 2024EweitzModified title
106517view23:28, 5 September 2019KhanspersModified description
106205view12:10, 16 August 2019MaintBotHMDB identifier normalization
105777view19:42, 15 August 2019KhanspersModified description
104982view19:15, 27 June 2019KhanspersModified description
94205view21:11, 25 August 2017DeSlAdded ID for thiazolidine compound class from ChEBI.
91095view01:11, 4 January 2017Khanspersfixed unconnected interactions, updated missing xrefs, added lit ref
90815view18:40, 14 December 2016KhanspersOntology Term : 'cell of skeletal muscle' added !
90814view18:39, 14 December 2016KhanspersOntology Term : 'white fat cell' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
9-cis-Retinoic acidMetaboliteHMDB0002369 (HMDB)
ACAA1GeneProductENSG00000060971 (Ensembl)
  • Original kegg element: gene;21;mmu:113868 mmu:235674
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235674
ACOX1GeneProductENSG00000161533 (Ensembl)
  • Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
ACSL1GeneProductENSG00000151726 (Ensembl)
  • Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
ADIPOQGeneProductENSG00000181092 (Ensembl)
  • Original kegg element: gene;53;mmu:11450
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
ANGPTL4GeneProductENSG00000167772 (Ensembl)
  • Original kegg element: gene;41;mmu:57875
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875
APOA1GeneProductENSG00000118137 (Ensembl)
  • Original kegg element: gene;61;mmu:11806
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806
APOA2GeneProductENSG00000158874 (Ensembl)
  • Original kegg element: gene;46;mmu:11807
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807
APOA5GeneProductENSG00000110243 (Ensembl)
  • Original kegg element: gene;64;mmu:66113
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113
APOC3GeneProductENSG00000110245 (Ensembl)
  • Original kegg element: gene;57;mmu:11814
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814
AQP7GeneProductENSG00000165269 (Ensembl)
  • Original kegg element: gene;7;mmu:11832
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832
Adaptive thermogenesisPathwayOriginal kegg element: map;52;path:mmu00564
Adipocyte differentiationPathwayOriginal kegg element: map;52;path:mmu00564
Adipocytokine signalingPathwayOriginal kegg element: map;34;path:mmu04920
CD36GeneProductENSG00000135218 (Ensembl)
  • Original kegg element: gene;11;mmu:12491
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491
CPT1CGeneProductENSG00000169169 (Ensembl)
  • Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070
CPT2GeneProductENSG00000157184 (Ensembl)
  • Original kegg element: gene;26;mmu:12896
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896
CYP27A1GeneProductENSG00000135929 (Ensembl)
  • Original kegg element: gene;60;mmu:104086
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086
CYP4A11GeneProductENSG00000187048 (Ensembl)
  • Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168
CYP7A1GeneProductENSG00000167910 (Ensembl)
  • Original kegg element: gene;33;mmu:13122
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122
CYP8B1GeneProductENSG00000180432 (Ensembl)
  • Original kegg element: gene;58;mmu:13124
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124
Cell survivalPathwayOriginal kegg element: map;52;path:mmu00564
ChylomicronMetaboliteQ423126 (Wikidata)
CiprofibrateMetaboliteCHEBI:50867 (ChEBI)
DBIGeneProductENSG00000155368 (Ensembl)
  • Original kegg element: gene;63;mmu:13167
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167
EHHADHGeneProductENSG00000113790 (Ensembl)
  • Original kegg element: gene;25;mmu:74147
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
EicosanoidMetaboliteCHEBI:23899 (ChEBI)
FABP1GeneProductENSG00000163586 (Ensembl)
  • Original kegg element: gene;44;mmu:14080
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080
FABP3GeneProductENSG00000121769 (Ensembl)
  • Original kegg element: gene;32;mmu:14077
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077
FABP4GeneProductENSG00000170323 (Ensembl)
  • Original kegg element: gene;40;mmu:11770
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770
FADS2GeneProductENSG00000134824 (Ensembl)
  • Original kegg element: gene;56;mmu:56473
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
GKGeneProductENSG00000198814 (Ensembl)
  • Original kegg element: gene;8;mmu:14626 mmu:14933
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626
GluconeogenesisPathwayOriginal kegg element: map;52;path:mmu00564
HMGCS2GeneProductENSG00000134240 (Ensembl)
  • Original kegg element: gene;37;mmu:15360
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360
ILKGeneProductENSG00000166333 (Ensembl)
  • Original kegg element: gene;43;mmu:16202
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202
LPLGeneProductENSG00000175445 (Ensembl)
  • Original kegg element: gene;30;mmu:16956
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956
Lipid metabolismPathwayOriginal kegg element: map;52;path:mmu00564
ME1GeneProductENSG00000065833 (Ensembl)
  • Original kegg element: gene;65;mmu:17436
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436
MMP1GeneProductENSG00000196611 (Ensembl)
  • Original kegg element: gene;39;mmu:83995 mmu:83996
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996
NR1H3GeneProductENSG00000025434 (Ensembl)
  • Original kegg element: gene;59;mmu:22259
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
OLR1GeneProductENSG00000173391 (Ensembl)
  • Original kegg element: gene;29;mmu:108078
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078
PCK1GeneProductENSG00000124253 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534
PCK2GeneProductENSG00000100889 (Ensembl)
  • Original kegg element: gene;9;mmu:18534 mmu:74551
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551
PDPK1GeneProductENSG00000140992 (Ensembl)
  • Original kegg element: gene;45;mmu:18607
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PLIN1GeneProductENSG00000166819 (Ensembl)
  • Original kegg element: gene;10;mmu:103968
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968
PLTPGeneProductENSG00000100979 (Ensembl)
  • Original kegg element: gene;47;mmu:18830
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830
PPARAGeneProductENSG00000186951 (Ensembl)
  • Original kegg element: gene;14;mmu:19013
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013
PPARDGeneProductENSG00000112033 (Ensembl)
  • Original kegg element: gene;16;mmu:19015
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015
PPARGGeneProductENSG00000132170 (Ensembl)
  • Original kegg element: gene;18;mmu:19016
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016
RXRAGeneProductENSG00000186350 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
RXRBGeneProductENSG00000204231 (Ensembl)
  • Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
RXRGGeneProductENSG00000143171 (Ensembl)
  • Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
SCDGeneProductENSG00000099194 (Ensembl)
  • Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065
SCP2GeneProductENSG00000116171 (Ensembl)
  • Original kegg element: gene;20;mmu:20280
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280
SLC27A1GeneProductENSG00000130304 (Ensembl)
  • Original kegg element: gene;36;mmu:26457 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457
SLC27A4GeneProductENSG00000167114 (Ensembl)
  • Original kegg element: gene;36;mmu:26457 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569
SLC27A5GeneProductENSG00000083807 (Ensembl)
  • Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459
SORBS1GeneProductENSG00000095637 (Ensembl)
  • Original kegg element: gene;38;mmu:20411
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411
Saturated fatty acidsMetaboliteCHEBI:26607 (ChEBI)
Thiazolidine derivativeMetaboliteCHEBI:35622 (ChEBI)
UBCGeneProductENSG00000150991 (Ensembl)
  • Original kegg element: gene;62;mmu:22190
  • No homologues found for original id L:22190
UCP1GeneProductENSG00000109424 (Ensembl)
  • Original kegg element: gene;66;mmu:22227
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227
UbiquitinationPathwayOriginal kegg element: map;52;path:mmu00564
Unsaturated fatty acidsMetaboliteCHEBI:27208 (ChEBI)
VLDLMetaboliteQ419074 (Wikidata)

Annotated Interactions

No annotated interactions

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