PPAR signaling (Homo sapiens)
From WikiPathways
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3942).
Quality Tags
Ontology Terms
Pathway Ontology : classic metabolic pathway
Bibliography
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- Takada I, Kato S; ''[PPARs target genes].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Desvergne B, Michalik L, Wahli W; ''Transcriptional regulation of metabolism.''; Physiol Rev, 2006 PubMed Europe PMC Scholia
- Inoue H; ''[Endogenous ligands for PPARs].''; Nihon Rinsho, 2005 PubMed Europe PMC Scholia
- Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; Prog Lipid Res, 2006 PubMed Europe PMC Scholia
- Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
- Desvergne B, Wahli W; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; Endocr Rev, 1999 PubMed Europe PMC Scholia
- Savage DB; ''PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.''; Expert Rev Mol Med, 2005 PubMed Europe PMC Scholia
- Semple RK, Chatterjee VK, O'Rahilly S; ''PPAR gamma and human metabolic disease.''; J Clin Invest, 2006 PubMed Europe PMC Scholia
- Lehrke M, Lazar MA; ''The many faces of PPARgamma.''; Cell, 2005 PubMed Europe PMC Scholia
- Hauner H; ''The mode of action of thiazolidinediones.''; Diabetes Metab Res Rev, 2002 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
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9-cis-Retinoic acid | Metabolite | HMDB0002369 (HMDB) ![]() | |
ACAA1 | GeneProduct | ENSG00000060971 (Ensembl) ![]() |
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ACOX1 | GeneProduct | ENSG00000161533 (Ensembl) ![]() |
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ACSL1 | GeneProduct | ENSG00000151726 (Ensembl) ![]() |
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ADIPOQ | GeneProduct | ENSG00000181092 (Ensembl) ![]() |
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ANGPTL4 | GeneProduct | ENSG00000167772 (Ensembl) ![]() |
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APOA1 | GeneProduct | ENSG00000118137 (Ensembl) ![]() |
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APOA2 | GeneProduct | ENSG00000158874 (Ensembl) ![]() |
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APOA5 | GeneProduct | ENSG00000110243 (Ensembl) ![]() |
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APOC3 | GeneProduct | ENSG00000110245 (Ensembl) ![]() |
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AQP7 | GeneProduct | ENSG00000165269 (Ensembl) ![]() |
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Adaptive thermogenesis | Pathway | Original kegg element: map;52;path:mmu00564 | |
Adipocyte differentiation | Pathway | Original kegg element: map;52;path:mmu00564 | |
Adipocytokine signaling | Pathway | Original kegg element: map;34;path:mmu04920 | |
CD36 | GeneProduct | ENSG00000135218 (Ensembl) ![]() |
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CPT1C | GeneProduct | ENSG00000169169 (Ensembl) ![]() |
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CPT2 | GeneProduct | ENSG00000157184 (Ensembl) ![]() |
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CYP27A1 | GeneProduct | ENSG00000135929 (Ensembl) ![]() |
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CYP4A11 | GeneProduct | ENSG00000187048 (Ensembl) ![]() |
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CYP7A1 | GeneProduct | ENSG00000167910 (Ensembl) ![]() |
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CYP8B1 | GeneProduct | ENSG00000180432 (Ensembl) ![]() |
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Cell survival | Pathway | Original kegg element: map;52;path:mmu00564 | |
Chylomicron | Metabolite | Q423126 (Wikidata) ![]() | |
Ciprofibrate | Metabolite | CHEBI:50867 (ChEBI) ![]() | |
DBI | GeneProduct | ENSG00000155368 (Ensembl) ![]() |
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EHHADH | GeneProduct | ENSG00000113790 (Ensembl) ![]() |
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Eicosanoid | Metabolite | CHEBI:23899 (ChEBI) ![]() | |
FABP1 | GeneProduct | ENSG00000163586 (Ensembl) ![]() |
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FABP3 | GeneProduct | ENSG00000121769 (Ensembl) ![]() |
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FABP4 | GeneProduct | ENSG00000170323 (Ensembl) ![]() |
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FADS2 | GeneProduct | ENSG00000134824 (Ensembl) ![]() |
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GK | GeneProduct | ENSG00000198814 (Ensembl) ![]() |
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Gluconeogenesis | Pathway | Original kegg element: map;52;path:mmu00564 | |
HMGCS2 | GeneProduct | ENSG00000134240 (Ensembl) ![]() |
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ILK | GeneProduct | ENSG00000166333 (Ensembl) ![]() |
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LPL | GeneProduct | ENSG00000175445 (Ensembl) ![]() |
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Lipid metabolism | Pathway | Original kegg element: map;52;path:mmu00564 | |
ME1 | GeneProduct | ENSG00000065833 (Ensembl) ![]() |
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MMP1 | GeneProduct | ENSG00000196611 (Ensembl) ![]() |
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NR1H3 | GeneProduct | ENSG00000025434 (Ensembl) ![]() |
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NSAIDs | Metabolite | CHEBI:35475 (ChEBI) ![]() | |
OLR1 | GeneProduct | ENSG00000173391 (Ensembl) ![]() |
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PCK1 | GeneProduct | ENSG00000124253 (Ensembl) ![]() |
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PCK2 | GeneProduct | ENSG00000100889 (Ensembl) ![]() |
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PDPK1 | GeneProduct | ENSG00000140992 (Ensembl) ![]() |
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PLIN1 | GeneProduct | ENSG00000166819 (Ensembl) ![]() |
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PLTP | GeneProduct | ENSG00000100979 (Ensembl) ![]() |
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PPARA | GeneProduct | ENSG00000186951 (Ensembl) ![]() |
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PPARD | GeneProduct | ENSG00000112033 (Ensembl) ![]() |
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PPARG | GeneProduct | ENSG00000132170 (Ensembl) ![]() |
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RXRA | GeneProduct | ENSG00000186350 (Ensembl) ![]() |
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RXRB | GeneProduct | ENSG00000204231 (Ensembl) ![]() |
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RXRG | GeneProduct | ENSG00000143171 (Ensembl) ![]() |
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SCD | GeneProduct | ENSG00000099194 (Ensembl) ![]() |
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SCP2 | GeneProduct | ENSG00000116171 (Ensembl) ![]() |
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SLC27A1 | GeneProduct | ENSG00000130304 (Ensembl) ![]() |
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SLC27A4 | GeneProduct | ENSG00000167114 (Ensembl) ![]() |
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SLC27A5 | GeneProduct | ENSG00000083807 (Ensembl) ![]() |
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SORBS1 | GeneProduct | ENSG00000095637 (Ensembl) ![]() |
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Saturated fatty acids | Metabolite | CHEBI:26607 (ChEBI) ![]() | |
Thiazolidine derivative | Metabolite | CHEBI:35622 (ChEBI) ![]() | |
UBC | GeneProduct | ENSG00000150991 (Ensembl) ![]() |
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UCP1 | GeneProduct | ENSG00000109424 (Ensembl) ![]() |
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Ubiquitination | Pathway | Original kegg element: map;52;path:mmu00564 | |
Unsaturated fatty acids | Metabolite | CHEBI:27208 (ChEBI) ![]() | |
VLDL | Metabolite | Q419074 (Wikidata) ![]() |
Annotated Interactions
No annotated interactions