Purine metabolism (Homo sapiens)
From WikiPathways
Description
Overview of purine metabolism. Metabolic markers are highlighted in red, with graphical arrows indicating if a marker is present in higher or lower concentrations compared to normal (healthy) levels.
This pathway was inspired by Chapter 13, edition 5 of the book of Blau (in press). The full version including disorders, based on ed. 4, can be found here.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Saving...Bibliography
- Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
- Blau, N., Duran, M., Gibson, K.M., Dionisi-Vici, C.; ''Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 11 and 41''; ISBN 978-3-642-40337-8, 2014
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2'-Deoxyadenosine | Metabolite | CHEBI:17256 (ChEBI)  | |
| 2'-deoxyinosine | Metabolite | CHEBI:28997 (ChEBI) | |
| 2,8-Dihydroxyadenine | Metabolite | Q4596812 (Wikidata) | |
| 2-Deoxyguanosine | Metabolite | CHEBI:17172 (ChEBI) | |
| ADA | Protein | P00813 (Uniprot-TrEMBL) | |
| ADP | Metabolite | CHEBI:456216 (ChEBI) | |
| ADSL | Protein | P30566 (Uniprot-TrEMBL) | |
| ADSS | Protein | P30520 (Uniprot-TrEMBL) | Adenylosuccinate synthetase isozyme 2 |
| AICA-riboside | Metabolite | CHEBI:28498 (ChEBI) | |
| AICARP | Metabolite | CHEBI:58475 (ChEBI) | |
| AMP | Metabolite | CHEBI:456215 (ChEBI) | |
| AMPD1 | Protein | P23109 (Uniprot-TrEMBL) | |
| APRT | Protein | P07741 (Uniprot-TrEMBL) | |
| ATIC | Protein | P31939 (Uniprot-TrEMBL) | |
| ATP | Metabolite | CHEBI:30616 (ChEBI) | |
| Adenine | Metabolite | CHEBI:16708 (ChEBI) | |
| Adenosine | Metabolite | CHEBI:16335 (ChEBI) | |
| DGUOK | Protein | Q16854 (Uniprot-TrEMBL) | |
| FAICARP | Metabolite | CHEBI:58467 (ChEBI) | |
| GDP | Metabolite | CHEBI:58189 (ChEBI) | |
| GMP | Metabolite | CHEBI:58115 (ChEBI) | |
| GTP | Metabolite | CHEBI:37565 (ChEBI) | |
| Guanine | Metabolite | CHEBI:16235 (ChEBI) | |
| Guanosine | Metabolite | CHEBI:16750 (ChEBI) | |
| HPRT1 | Protein | P00492 (Uniprot-TrEMBL) | |
| Hypoxanthine | Metabolite | CHEBI:17368 (ChEBI) | |
| IMP | Metabolite | CHEBI:58053 (ChEBI) | |
| IMPDH1 | Protein | P20839 (Uniprot-TrEMBL) | |
| ITPA | Protein | Q9BY32 (Uniprot-TrEMBL) | |
| ITP | Metabolite | CHEBI:61402 (ChEBI) | is a nucleoside triphosphate(4−) |
| Inosine | Metabolite | CHEBI:17596 (ChEBI) | |
| More detail:
Purine metabolism and related disorders | Pathway | WP4224 (WikiPathways) | |
| PNP | Protein | P00491 (Uniprot-TrEMBL) | |
| PRPP | Metabolite | CHEBI:17111 (ChEBI) | |
| PRPPs | Protein | 2.7.6.1 (Enzyme Nomenclature) | |
| PRPS1 | Protein | P60891 (Uniprot-TrEMBL) | |
| RR | Protein | 1.17.4.1 (Enzyme Nomenclature) | |
| Ribose-5-P | Metabolite | CHEBI:52742 (ChEBI) | |
| S-AMP | Metabolite | CHEBI:57567 (ChEBI) | succinyladenosine monophosphate |
| SAICA-riboside | Metabolite | CHEBI:18319 (ChEBI) | |
| SAICARP | Metabolite | CHEBI:58443 (ChEBI) | |
| Succinyladenosine | Metabolite | CHEBI:71169 (ChEBI) | |
| Urate | Metabolite | CHEBI:17775 (ChEBI) | |
| XMP | Metabolite | CHEBI:57464 (ChEBI) | |
| XO | Protein | P47989 (Uniprot-TrEMBL) | |
| Xanthine | Metabolite | CHEBI:17712 (ChEBI) | |
| Xanthosine | Metabolite | CHEBI:18107 (ChEBI) | |
| dADP | Metabolite | CHEBI:57667 (ChEBI) | |
| dAMP | Metabolite | CHEBI:58245 (ChEBI) | |
| dATP | Metabolite | CHEBI:61404 (ChEBI) | |
| dGDP | Metabolite | CHEBI:58595 (ChEBI) | |
| dGMP | Metabolite | CHEBI:57673 (ChEBI) | |
| dGTP | Metabolite | CHEBI:16497 (ChEBI) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| 2'-Deoxyadenosine | 2'-deoxyinosine | mim-conversion | 28191 (Rhea) | |
| 2'-Deoxyadenosine | Adenine | mim-conversion | 27743 (Rhea) | |
| 2'-deoxyinosine | Hypoxanthine | mim-conversion | 27751 (Rhea) | |
| 2-Deoxyguanosine | Guanine | mim-conversion | 27739 (Rhea) | |
| 2-Deoxyguanosine | dGMP | mim-conversion | 19202 (Rhea) | |
| ADP | ATP | mim-conversion | 30657 (Rhea) | |
| ADP | dADP | mim-conversion | 28036 (Rhea) | |
| AICARP | FAICARP | mim-conversion | 22193 (Rhea) | |
| AMP | ADP | mim-conversion | 11462 (Rhea) | |
| AMP | Adenosine | mim-conversion | 29376 (Rhea) | |
| AMP | IMP | mim-conversion | 14778 (Rhea) | |
| Adenine | AMP | mim-conversion | 16611 (Rhea) | |
| Adenosine | Adenine | mim-conversion | 18670 (Rhea) | |
| Adenosine | Inosine | mim-conversion | 24409 (Rhea) | |
| FAICARP | IMP | mim-conversion | 18447 (Rhea) | |
| GDP | GTP | mim-conversion | 29865 (Rhea) | |
| GDP | dGDP | mim-conversion | 28032 (Rhea) | |
| GMP | GDP | mim-conversion | 20781 (Rhea) | |
| GMP | Guanosine | mim-conversion | 27715 (Rhea) | |
| Guanine | mim-conversion | 14666 (Rhea) | ||
| Guanine | mim-conversion | 25426 (Rhea) | ||
| Guanosine | Guanine | mim-conversion | 13234 (Rhea) | |
| Hypoxanthine | Xanthine | mim-conversion | 24671 (Rhea) | |
| Hypoxanthine | mim-conversion | 17975 (Rhea) | ||
| IMP | Inosine | mim-conversion | 27719 (Rhea) | |
| IMP | S-AMP | mim-conversion | 15754 (Rhea) | |
| IMP | XMP | mim-conversion | 11709 (Rhea) | |
| ITP | IMP | mim-conversion | 29400 (Rhea) | |
| Inosine | Hypoxanthine | mim-conversion | 16658 (Rhea) | |
| S-AMP | AMP | mim-conversion | 16854 (Rhea) | |
| SAICARP | AICARP | mim-conversion | 23921 (Rhea) | |
| XMP | GMP | mim-conversion | 18302 (Rhea) | |
| XMP | Xanthosine | mim-conversion | 28531 (Rhea) | |
| Xanthine | Urate | mim-conversion | 16670 (Rhea) | |
| Xanthosine | Xanthine | mim-conversion | 27639 (Rhea) | |
| dADP | dAMP | mim-conversion | 23102 (Rhea) | |
| dADP | dATP | mim-conversion | 27675 (Rhea) | |
| dAMP | 2'-Deoxyadenosine | mim-conversion | 29372 (Rhea) | |
| dGDP | dGMP | mim-conversion | 12699 (Rhea) | |
| dGDP | dGTP | mim-conversion | 27691 (Rhea) | |
| dGMP | 2-Deoxyguanosine | mim-conversion | 19203 (Rhea) |
