Neolacto series sphingolipid metabolism (Homo sapiens)
From WikiPathways
Description
Neolacto series glycosphingolipid bisynthesis.The neolacto series are derived from lactosylceramides (abbreviated as LacCer), which are a class of glycosphingolipids connecting a ceramide lipid to a sugar group. These lipids can have various biological functions that we are not aware of at the moment. Silencing of the B3GNT5 gene was found to lead to various issues in mouse models, including preimplantation lethality, early death, growth inhibition, loss of fur, obesity, reproductive problems, and B-cell functional defects. Source: PMID:24165035.
Quality Tags
Ontology Terms
Saving...Bibliography
- ''Handbook of Glycosyltransferases and Related Genes''; doi.org/10.1007/978-4-431-67877-9, 2002
- Merril AH Jr; ''SphinGOMAP--a web-based biosynthetic pathway map of sphingolipids and glycosphingolipids.''; Glycobiology, 2005 PubMed Europe PMC Scholia
- D'Angelo G, Capasso S, Sticco L, Russo D; ''Glycosphingolipids: synthesis and functions.''; FEBS J, 2013 PubMed Europe PMC Scholia
- Yamashiro S, Haraguchi M, Furukawa K, Takamiya K, Yamamoto A, Nagata Y, Lloyd KO, Shiku H; ''Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| B3GNT5 | GeneProduct | Q9BYG0 (Uniprot-TrEMBL)  | |
| B4GALT1 | GeneProduct | P15291 (Uniprot-TrEMBL) | |
| B4GALT3 | GeneProduct | O60512 (Uniprot-TrEMBL) | |
| B4GALT4 | GeneProduct | O60513 (Uniprot-TrEMBL) | |
| FUCA1 | GeneProduct | P04066 (Uniprot-TrEMBL) | |
| FUT1 | GeneProduct | P19526 (Uniprot-TrEMBL) | |
| FUT2 | GeneProduct | Q10981 (Uniprot-TrEMBL) | |
| FUT5 | GeneProduct | Q11128 (Uniprot-TrEMBL) | |
| H1 glycolipid, type II antigen | Metabolite | LMSP0505AD00 (LIPID MAPS) | |
| LacCer | Metabolite | LMSP0501AB00 (LIPID MAPS) | |
| Lacto series | Pathway | WP5303 (WikiPathways) | |
| Lc3Cer | Metabolite | LMSP0504AA00 (LIPID MAPS) | |
| NAGA | GeneProduct | P17050 (Uniprot-TrEMBL) | |
| NEU2 | GeneProduct | Q9Y3R4 (Uniprot-TrEMBL) | |
| NeuAcα2-8NeuAcα2-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ-Cer | Metabolite | LMSP0601EG00 (LIPID MAPS) | |
| SSEA-1, Lex-5 | Metabolite | LMSP0505AB00 (LIPID MAPS) | |
| ST3GAL4 | GeneProduct | Q11206 (Uniprot-TrEMBL) | |
| Sialosylparagloboside | Metabolite | LMSP0601EF00 (LIPID MAPS) | |
| Sialyl LeX | Metabolite | LMSP0601EE00 (LIPID MAPS) | |
| Type II A antigen | Metabolite | LMSP0505AF00 (LIPID MAPS) | |
| nLc4Cer | Metabolite | LMSP0505AA00 (LIPID MAPS) | ChEBI 17292, Smap 8 |
| nLc5Cer | Metabolite | LMSP0505AK00 (LIPID MAPS) | |
| nLc6Cer i antigen | Metabolite | LMSP0505AL00 (LIPID MAPS) |
Annotated Interactions
| View all... |
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| H1 glycolipid, type II antigen | nLc4Cer | mim-conversion | 48225 (Rhea) | |
| LacCer | Lc3Cer | mim-conversion | 13906 (Rhea) | |
| Lc3Cer | nLc4Cer | mim-conversion | 31500 (Rhea) | |
| Sialosylparagloboside | nLc4Cer | mim-conversion | 47853 (Rhea) | |
| Type II A antigen | H1 glycolipid, type II antigen | mim-conversion | 48213 (Rhea) | |
| nLc4Cer | H1 glycolipid, type II antigen | mim-conversion | 48305 (Rhea) | |
| nLc4Cer | SSEA-1, Lex-5 | mim-conversion | 48333 (Rhea) | |
| nLc4Cer | Sialosylparagloboside | mim-conversion | 18914 (Rhea) | |
| nLc4Cer | nLc5Cer | mim-conversion | 23005 (Rhea) |
