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- Pathway:WP722 <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ... <Comment>Coexpression of the human 5-HT(1D) receptor with Galpha(i1), alpha(i2), alpha(i3), or Galpha(o)-prot ...709 KB (96586 words) - 14:31, 9 March 2023
- Pathway:WP1784 ... t al., 2003). Evidence for this reaction comes from experiments using both human and rabbit proteins.</Comment> ... ww.w3.org/2001/XMLSchema#string">Subunit structures and stoichiometries of human DNA fragmentation factor proteins before and after induction of apoptosis. ...247 KB (26670 words) - 16:34, 25 January 2021
- Pathway:WP2799 ... eight insulin-like growth factor-binding protein-3 association proteins in human serum.</bp:TITLE> ... p:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced ...215 KB (23978 words) - 10:28, 11 May 2021
- Pathway:WP1841 ... ave been observed in several tumor cell lines and malignant specimens from human patients underlying its importance in regulating inflammatory and apoptoti ... ... owing a significantly lower expression of UACA mRNAs and protein levels in human non-small cell lung carcinoma (NSCLC) cell lines and NSCLC tumours suggest ...320 KB (36217 words) - 16:48, 25 January 2021
- Pathway:WP2786 <Comment Source="WikiPathways-description">In humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, ... ... presence of Rbpj (Raafat et al. 2009). JAG1 and NOTCH4 are upregulated in human ER+ breast cancers resistant to anti-estrogen therapy, which correlates wi ...397 KB (45897 words) - 09:01, 9 July 2022
- Pathway:WP2714 ... ascade in humans are unknown.<p>Four additional processes related to human Hippo signaling, although incompletely characterized, have been described ... ... not been demonstrated experimentally but is inferred from the activity of human paralogue LATS2 and of mouse homologue LATS1 (Varelas et al. 2010).</Comme ...146 KB (16136 words) - 16:55, 25 January 2021
- Pathway:WP2722 ... Several sites related to the consensus RBPJ binding sequence exist in the human FABP7 gene promoter.</Comment> ... human and rat lungs, with NOTCH3 and HES5 levels increased in hypertensive human and rat lung tissues (Li et al. 2009).</Comment>211 KB (22866 words) - 16:30, 25 January 2021
- Pathway:WP2735 ... cers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts an ... ... PI3K and JAK/STAT (Reber et al. 2006, Ronnstrand 2004). Defects of KIT in humans are associated with different genetic diseases and also in several types ...919 KB (109879 words) - 16:25, 25 January 2021
- Pathway:WP2752 ... LR4 and TLR3 signaling pathways were shown to mediate apoptosis in various human cell lines in the FADD:caspasse-8-dependent manner [Kalai M et al 2002; Ka ... ... on the last three C-terminal lysine sites (positions 444, 446, and 452) of human IRF7 independently of its C-terminal functional phosphorylation sites.[Nin ...257 KB (29606 words) - 16:19, 25 January 2021
- Pathway:WP2762 ... get cell, thereby blocking protein synthesis. Neither fragment is toxic to human cells by itself (Collier 1975; Pappenheim 1977; Murphy 2011).</Comment> ... ′-ADP (Lee RW & Huttner WB 1983). Structural studies showed that human TPSTs share the same catalytic mechanism (Teramoto T et al. 2013; Tanaka S ...259 KB (28900 words) - 16:34, 25 January 2021
- Pathway:WP2766 ... pa et al. 1971, Halestrap & Denton 1974), and the stoichiometry of the human reaction is inferred from this work. MCP1 and MCP2 have been identified as ... ... ent anion-selective channel protein 1 (VDAC1) (McCommis & Finck 2015). Humans with defective VDAC1 show impaired PYR oxidation and ATP production (Huiz ...255 KB (28841 words) - 07:12, 15 July 2022
- Pathway:WP3352 ... [Feoktistova M et al 2011]. In addition, in caspase-8- or FADD-deficient human Jurkat cells dsRNA induced programmed necrosis, instead of apoptosis [Kala ... ... CAM1-dependent NFkappaB activaion, RANTES production and IRF activation in human embryonic kidney HEK293 cells (Carty M et al. 2006). Moreover, suppression ...267 KB (31239 words) - 11:05, 7 May 2021
- Pathway:WP3354 ... tumors (Mortezai et al. 2013, van Vliet et al. 2005). CLEC10A on immature human monocyte-derived DCs has been shown to recognize and internalize the three ... <Comment Source="Reactome">In humans, the IkB kinase (IKK) complex serves as the master regulator for the acti ...527 KB (58739 words) - 09:43, 7 August 2022
- Pathway:WP3358 ... LR4 and TLR3 signaling pathways were shown to mediate apoptosis in various human cell lines in the FADD:caspasse-8-dependent manner [Kalai M et al 2002; Ka ... ... ma#string">Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signals. ...113 KB (13258 words) - 11:59, 22 May 2021
- Pathway:WP3380 ... n co-expressed with NFkB inducers (such as TNFR1, DR3, TNFR2, Fas etc.) in human embryonic kidney 293 (HEK293) cells or upon treatment with TNF (Imler M et ... ... ). Disrupted cleavage of RIPK1 variants with mutations at D324 by CASP8 in humans leads to an autoinflammatory response by promoting the activation of RIPK ...311 KB (36685 words) - 16:46, 25 January 2021
- Pathway:WP3959 ... rs including cancer. The accurate preservation of chromosome continuity in human cells during either DNA replication or repair is critical for preventing t ... ... of the cellular response after DSBs by IR through the activation of ATM in human cells.</Comment>775 KB (106109 words) - 22:34, 8 August 2024
- Pathway:WP4016 ... and activating damage response pathways. A structural homologue of rad3 in humans has been identified based on sequence similarity in the protein kinase do ... ... that overexpression of a catalytically inactive version of ATR (ATRki) in human fibroblasts caused hypersensitivity to gamma-radiation and hydroxyurea and ...1.07 MB (153325 words) - 00:23, 23 December 2021
- Pathway:WP3802 ... o be rapidly endocytosed via clathrin-dependent and -independent manner in human Burkitt's lymphoma B cells (BJAB) (Kohlhaas SL et al. 2007). However, FADD ... ... brain (Seabra et al. 1992), but the complex is evolutionarily conserved in human cells (Baron and Seabra 2008).</Comment>323 KB (37268 words) - 16:57, 25 January 2021
- Pathway:WP4096 <Comment Source="Reactome">Human Bromodomain and WD repeat-containing protein 1 (BRWD1) binds to histone H3 ... ... he hyperacetylation of H4K16 (Lavender et al. 1994, Smith et al. 2000). In humans MSL is responsible for the majority of H4 acetylation at lysine-17 in the ...678 KB (75075 words) - 16:30, 25 January 2021
- Pathway:WP1935 ... and for rapid urea equilibrium in non-renal tissues. Two carriers exist in humans, encoded by SLC14A1 and ALC14A2 (Olives et al. 1994).<br>Choline up ... ... orter ZnT7. It is thought to be present in the small intestine and lung in humans (Kirschke CP and Huang L, 2003). Functional properties assigned to ZnT7 a ...470 KB (52956 words) - 16:47, 25 January 2021
