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- Pathway:WP722 10854065 (CellType: spermatid) Moreover, in mouse spermatids, i.e., the haploid cytodifferentiating cells, a so far unidenti ... ... g/2001/XMLSchema#string">Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.</bp:TI ...709 KB (96586 words) - 14:31, 9 March 2023
- Pathway:WP1784 ... ase-3 was found to be responsible for TJP1 (ZO-1) cleavage in both dog and mouse cells (Chin et al. 2006, Zehendner et al. 2011).</Comment>247 KB (26670 words) - 16:34, 25 January 2021
- Pathway:WP2799 ... th factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells.</bp:TITLE>215 KB (23978 words) - 10:28, 11 May 2021
- Pathway:WP1841 ... s subsequent phosphorylation of BAD on serine residue S118 (corresponds to mouse serine S155), which disrupts binding of BAD to BCL2 proteins and promotes ... ... mitochondrial partner BAK to release cytochrome c. It has been observed in mouse systems that the activated tBID results in an allosteric activation of BAK ...320 KB (36217 words) - 16:48, 25 January 2021
- Pathway:WP2786 ... of the vascular system. Overexpression of constitutively active Notch4 in mouse embryonic vasculature results in abnormal vessel structure and patterning ... ... -dependent and HES5-dependent transcription (Dang et al. 2006).<p>In mouse spinal cord, Notch3 is involved in neuronal differentiation and maturation ...397 KB (45897 words) - 09:01, 9 July 2022
- Pathway:WP2714 ... mentally but is inferred from the activity of human paralogue LATS2 and of mouse homologue LATS1 (Varelas et al. 2010).</Comment>146 KB (16136 words) - 16:55, 25 January 2021
- Pathway:WP2722 ... -dependent and HES5-dependent transcription (Dang et al. 2006).<p>In mouse spinal cord, Notch3 is involved in neuronal differentiation and maturation ... <Comment Source="Reactome">Based on a study with mouse proteins, NOTCH3 receptor binds to DLL1 ligand (Shimizu et al. 2000). The ...211 KB (22866 words) - 16:30, 25 January 2021
- Pathway:WP2735 ... ers of ERBB4 with EGFR and dimers of ERBB4 with ERBB3 were demonstrated in mouse cell lines in which human ERBB4 and EGFR or ERBB3 were exogenously express ... ... inhibits malignant growth in RAS-activated human cancer cell lines and in mouse models. In addition, RAS signaling increases protein levels of both MAPK12 ...919 KB (109879 words) - 16:25, 25 January 2021
- Pathway:WP2752 ... programmed necrosis (necroptosis) is mediated by the TRIF-RIP3 pathway in mouse macrophages [He S e al 2011]. RIP3 was shown to be essential mediator in T ... ... nflammatory cytokines and type I interferon in LPS or poly(I-C)-stimulated mouse peritoneal macrophages. SHP-2 overexpression also inhibited TRIF-induced I ...257 KB (29606 words) - 16:19, 25 January 2021
- Pathway:WP2762 ... al. 2013; Bar et al. 2008) and more limited studies of interactions among mouse and human ones (Liu et al. 2004). The identification of DPH2 as the cataly ...259 KB (28900 words) - 16:34, 25 January 2021
- Pathway:WP2766 ... string">Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs.</bp:TITLE>255 KB (28841 words) - 07:12, 15 July 2022
- Pathway:WP3352 ... programmed necrosis (necroptosis) is mediated by the TRIF-RIP3 pathway in mouse macrophages [He S e al 2011]. RIP3 was shown to be essential mediator in T ... ... nflammatory cytokines and type I interferon in LPS or poly(I-C)-stimulated mouse peritoneal macrophages. SHP-2 overexpression also inhibited TRIF-induced I ...267 KB (31239 words) - 11:05, 7 May 2021
- Pathway:WP3354 ... motif. Two highly conserved amino acids (222W 224H in Human; 221W, 223H in Mouse) within the CTLD which have been identified as essential for beta-glucan b ... ... binds to phosphorylated Tyr-348 (Tyr-342 in mouse) and Tyr-352 (Tyr-346 in mouse) in SYK with its C-terminal SH2 domain (Law et al. 1996). PLCG2 functions ...527 KB (58739 words) - 09:43, 7 August 2022
- Pathway:WP3959 ... df:datatype="http://www.w3.org/2001/XMLSchema#string">Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombi ... ... e DNA damage checkpoint protein RAD9A is essential for male meiosis in the mouse.</bp:TITLE>775 KB (106109 words) - 22:34, 8 August 2024
- Pathway:WP4016 ... <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae ... ... df:datatype="http://www.w3.org/2001/XMLSchema#string">Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombi ...1.07 MB (153325 words) - 00:23, 23 December 2021
- Pathway:WP3802 ... ntagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.</bp:TITLE> ... th factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells.</bp:TITLE>323 KB (37268 words) - 16:57, 25 January 2021
- Pathway:WP4096 ... due T11 in various combinations in vitro (Filippakopoulos et al. 2012). In mouse, it was confirmed that BRWD1 interacts with histone H3 acetylated at lysin ... ... ependent growth to Ba/F3 cells and induces a myeloproliferative disease in mouse models (Akada et al. 2010, Marty et al., 2010, Mullally et al. 2010). JAK2 ...678 KB (75075 words) - 16:30, 25 January 2021
- Pathway:WP1935 ... Functional properties assigned to ZnT7 are based on studies conducted with mouse experiments.</Comment> ... sues. The functionality of ZIP5 as a zinc transporter was determined using mouse protein (mZIP5) (Wang F et al, 2004).</Comment>470 KB (52956 words) - 16:47, 25 January 2021
- Pathway:WP5022 ... completely understood and may vary across species (Davies KA et al. 2020). Mouse MLKL activation relies on transient engagement of RIPK3 to facilitate phos ... ... timuli treatment in both human colorectal adenocarcinoma cells (HT-29) and mouse embryonic fibroblasts (MEF). PELI1:RIPK3 interaction was further studied b ...286 KB (34922 words) - 22:55, 2 February 2024
