Portal:CPTAC/Hallmark/immortality
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Current revision (00:13, 11 October 2019) (view source) (removed breast cancer main model) |
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| + | Cancer cells require unlimited replicative potential in order to generate macroscopic tumors. | ||
| + | Telomeres protecting the ends of chromosomes normally shorten with successive cell generations, but cancer cells have higher levels of telomerase, an enzyme that adds length to telomeres. (Adapted from [https://www.ncbi.nlm.nih.gov/pubmed/21376230 Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011]) | ||
*[[Pathway:WP268]] Notch Signaling | *[[Pathway:WP268]] Notch Signaling | ||
*[[Pathway:WP3658]] Wnt/beta-catenin Signaling Pathway in Leukemia | *[[Pathway:WP3658]] Wnt/beta-catenin Signaling Pathway in Leukemia | ||
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*[[Pathway:WP4258]] LncRNA involvement in canonical Wnt signaling and colorectal cancer | *[[Pathway:WP4258]] LncRNA involvement in canonical Wnt signaling and colorectal cancer | ||
*[[Pathway:WP4336]] ncRNAs involved in Wnt signaling in hepatocellular carcinoma | *[[Pathway:WP4336]] ncRNAs involved in Wnt signaling in hepatocellular carcinoma | ||
| + | *[[Pathway:WP4337]] ncRNAs involved in STAT3 signaling in hepatocellular carcinoma | ||
Current revision
Cancer cells require unlimited replicative potential in order to generate macroscopic tumors. Telomeres protecting the ends of chromosomes normally shorten with successive cell generations, but cancer cells have higher levels of telomerase, an enzyme that adds length to telomeres. (Adapted from Hallmarks of cancer: the next generation, Hanahan and Weinberg, Cell 2011)
- Pathway:WP268 Notch Signaling
- Pathway:WP3658 Wnt/beta-catenin Signaling Pathway in Leukemia
- Pathway:WP3664 Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
- Pathway:WP428 Wnt Signaling Pathway
- Pathway:WP61 Notch Signaling Pathway
- Pathway:WP363 Wnt Signaling Pathway
- Pathway:WP4258 LncRNA involvement in canonical Wnt signaling and colorectal cancer
- Pathway:WP4336 ncRNAs involved in Wnt signaling in hepatocellular carcinoma
- Pathway:WP4337 ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
